Skip to main content

Genetic variants associated with vein graft stenosis after coronary artery bypass grafting.

Publication ,  Journal Article
Shah, AA; Haynes, C; Craig, DM; Sebek, J; Grass, E; Abramson, K; Hauser, E; Gregory, SG; Kraus, WE; Smith, PK; Shah, SH
Published in: Heart Surg Forum
February 27, 2015

BACKGROUND: Vein graft stenosis after coronary artery bypass grafting (CABG) is common. Identifying genes associated with vein graft stenosis after CABG could reveal novel mechanisms of disease and discriminate patients at risk for graft failure. We hypothesized that genome-wide association would identify these genes. METHODS: We performed a genome-wide association study on a subset of patients presenting for cardiac catheterization for concern of ischemic heart disease, who also underwent CABG and subsequent coronary angiography after CABG for clinical indications (n = 521). Cases were defined as individuals with ≥50% stenosis in any vein graft on any cardiac catheterization, and controls were defined as those who did not have vein graft stenosis on any subsequent cardiac catheterization. Multivariable logistic regression was used to assess the association between single nucleotide polymorphisms (SNPs) and vein graft stenosis. RESULTS: Sixty-nine percent of patients had vein graft failure after CABG. Seven SNPs were significantly associated with vein graft stenosis, including intronic SNPs in the genes PALLD (Rs6854137, P = 3.77 × 10(-6)), ARID1B (Rs184074, P = 5.97 × 10(-6)), and TMEM123 (Rs11225247, P = 8.25 × 10(-6)); and intergenic SNPs near the genes ABCA13 (Rs10232860, P = 4.54 × 10(-6)), RMI2 (Rs9921338, P = 6.15 × 10(-6)), PRM2 (Rs7198849, P = 7.27 × 10(-6)), and TNFSF4 (Rs17346536, P = 9.33 × 10(-6)). CONCLUSIONS: We have identified novel genetic variants that may predispose to risk of vein graft failure after CABG, many within biologically plausible pathways. These polymorphisms merit further investigation, as they could assist in stratifying patients with multi-vessel coronary artery disease, which could lead to alterations in management and revascularization strategy.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Heart Surg Forum

DOI

EISSN

1522-6662

Publication Date

February 27, 2015

Volume

18

Issue

1

Start / End Page

E1 / E5

Location

United States

Related Subject Headings

  • Saphenous Vein
  • Risk Factors
  • Prevalence
  • Polymorphism, Single Nucleotide
  • North Carolina
  • Middle Aged
  • Male
  • Humans
  • Graft Occlusion, Vascular
  • Genome-Wide Association Study
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shah, A. A., Haynes, C., Craig, D. M., Sebek, J., Grass, E., Abramson, K., … Shah, S. H. (2015). Genetic variants associated with vein graft stenosis after coronary artery bypass grafting. Heart Surg Forum, 18(1), E1–E5. https://doi.org/10.1532/hsf.1214
Shah, Asad A., Carol Haynes, Damian M. Craig, Jacqueline Sebek, Elizabeth Grass, Karen Abramson, Elizabeth Hauser, et al. “Genetic variants associated with vein graft stenosis after coronary artery bypass grafting.Heart Surg Forum 18, no. 1 (February 27, 2015): E1–5. https://doi.org/10.1532/hsf.1214.
Shah AA, Haynes C, Craig DM, Sebek J, Grass E, Abramson K, et al. Genetic variants associated with vein graft stenosis after coronary artery bypass grafting. Heart Surg Forum. 2015 Feb 27;18(1):E1–5.
Shah, Asad A., et al. “Genetic variants associated with vein graft stenosis after coronary artery bypass grafting.Heart Surg Forum, vol. 18, no. 1, Feb. 2015, pp. E1–5. Pubmed, doi:10.1532/hsf.1214.
Shah AA, Haynes C, Craig DM, Sebek J, Grass E, Abramson K, Hauser E, Gregory SG, Kraus WE, Smith PK, Shah SH. Genetic variants associated with vein graft stenosis after coronary artery bypass grafting. Heart Surg Forum. 2015 Feb 27;18(1):E1–E5.

Published In

Heart Surg Forum

DOI

EISSN

1522-6662

Publication Date

February 27, 2015

Volume

18

Issue

1

Start / End Page

E1 / E5

Location

United States

Related Subject Headings

  • Saphenous Vein
  • Risk Factors
  • Prevalence
  • Polymorphism, Single Nucleotide
  • North Carolina
  • Middle Aged
  • Male
  • Humans
  • Graft Occlusion, Vascular
  • Genome-Wide Association Study