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Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.

Publication ,  Journal Article
Singh, A; Babyak, MA; Sims, M; Musani, SK; Brummett, BH; Jiang, R; Kraus, WE; Shah, SH; Siegler, IC; Hauser, ER; Williams, RB
Published in: Transl Psychiatry
October 20, 2020

In prior work, we identified a novel gene-by-stress association of EBF1's common variation (SNP rs4704963) with obesity (i.e., hip, waist) in Whites, which was further strengthened through multiple replications using our synthetic stress measure. We now extend this prior work in a precision medicine framework to find the risk group using harmonized data from 28,026 participants by evaluating the following: (a) EBF1 SNPxSTRESS interaction in Blacks; (b) 3-way interaction of EBF1 SNPxSTRESS with sex, race, and age; and (c) a race and sex-specific path linking EBF1 and stress to obesity to fasting glucose to the development of cardiometabolic disease risk. Our findings provided additional confirmation that genetic variation in EBF1 may contribute to stress-induced human obesity, including in Blacks (P = 0.022) that mainly resulted from race-specific stress due to "racism/discrimination" (P = 0.036) and "not meeting basic needs" (P = 0.053). The EBF1 gene-by-stress interaction differed significantly (P = 1.01e-03) depending on the sex of participants in Whites. Race and age also showed tentative associations (Ps = 0.103, 0.093, respectively) with this interaction. There was a significant and substantially larger path linking EBF1 and stress to obesity to fasting glucose to type 2 diabetes for the EBF1 minor allele group (coefficient = 0.28, P = 0.009, 95% CI = 0.07-0.49) compared with the same path for the EBF1 major allele homozygotes in White females and also a similar pattern of the path in Black females. Underscoring the race-specific key life-stress indicators (e.g., racism/discrimination) and also the utility of our synthetic stress, we identified the potential risk group of EBF1 and stress-induced human obesity and cardiometabolic disease.

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Published In

Transl Psychiatry

DOI

EISSN

2158-3188

Publication Date

October 20, 2020

Volume

10

Issue

1

Start / End Page

351

Location

United States

Related Subject Headings

  • Trans-Activators
  • Stress, Psychological
  • Sex Factors
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Obesity
  • Male
  • Humans
  • Female
  • Diabetes Mellitus, Type 2
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Singh, A., Babyak, M. A., Sims, M., Musani, S. K., Brummett, B. H., Jiang, R., … Williams, R. B. (2020). Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants. Transl Psychiatry, 10(1), 351. https://doi.org/10.1038/s41398-020-01028-5
Singh, Abanish, Michael A. Babyak, Mario Sims, Solomon K. Musani, Beverly H. Brummett, Rong Jiang, William E. Kraus, et al. “Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.Transl Psychiatry 10, no. 1 (October 20, 2020): 351. https://doi.org/10.1038/s41398-020-01028-5.
Singh A, Babyak MA, Sims M, Musani SK, Brummett BH, Jiang R, et al. Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants. Transl Psychiatry. 2020 Oct 20;10(1):351.
Singh, Abanish, et al. “Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.Transl Psychiatry, vol. 10, no. 1, Oct. 2020, p. 351. Pubmed, doi:10.1038/s41398-020-01028-5.
Singh A, Babyak MA, Sims M, Musani SK, Brummett BH, Jiang R, Kraus WE, Shah SH, Siegler IC, Hauser ER, Williams RB. Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants. Transl Psychiatry. 2020 Oct 20;10(1):351.

Published In

Transl Psychiatry

DOI

EISSN

2158-3188

Publication Date

October 20, 2020

Volume

10

Issue

1

Start / End Page

351

Location

United States

Related Subject Headings

  • Trans-Activators
  • Stress, Psychological
  • Sex Factors
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Obesity
  • Male
  • Humans
  • Female
  • Diabetes Mellitus, Type 2