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Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.

Publication ,  Journal Article
Ward-Caviness, CK; Russell, AG; Weaver, AM; Slawsky, E; Dhingra, R; Kwee, LC; Jiang, R; Neas, LM; Diaz-Sanchez, D; Devlin, RB; Cascio, WE ...
Published in: Aging (Albany NY)
December 7, 2020

BACKGROUND: Accelerated epigenetic age has been proposed as a biomarker of increased aging, which may indicate disruptions in cellular and organ system homeostasis and thus contribute to sensitivity to environmental exposures. METHODS: Using 497 participants from the CATHGEN cohort, we evaluated whether accelerated epigenetic aging increases cardiovascular sensitivity to traffic-related air pollution (TRAP) exposure. We used residential proximity to major roadways and source apportioned air pollution models as measures of TRAP exposure, and chose peripheral arterial disease (PAD) and blood pressure as outcomes based on previous associations with TRAP. We used Horvath epigenetic age acceleration (AAD) and phenotypic age acceleration (PhenoAAD) as measures of age acceleration, and adjusted all models for chronological age, race, sex, smoking, and socioeconomic status. RESULTS: We observed significant interactions between TRAP and both AAD and PhenoAAD. Interactions indicated that increased epigenetic age acceleration elevated associations between proximity to roadways and PAD. Interactions were also observed between AAD and gasoline and diesel source apportioned PM2.5. CONCLUSION: Epigenetic age acceleration may be a biomarker of sensitivity to air pollution, particularly for TRAP in urban cohorts. This presents a novel means by which to understand sensitivity to air pollution and provides a molecular measure of environmental sensitivity.

Duke Scholars

Published In

Aging (Albany NY)

DOI

EISSN

1945-4589

Publication Date

December 7, 2020

Volume

12

Issue

23

Start / End Page

24141 / 24155

Location

United States

Related Subject Headings

  • Vehicle Emissions
  • Urban Health
  • Traffic-Related Pollution
  • Risk Assessment
  • Residence Characteristics
  • Peripheral Arterial Disease
  • North Carolina
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Ward-Caviness, C. K., Russell, A. G., Weaver, A. M., Slawsky, E., Dhingra, R., Kwee, L. C., … Kraus, W. E. (2020). Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution. Aging (Albany NY), 12(23), 24141–24155. https://doi.org/10.18632/aging.202341
Ward-Caviness, Cavin K., Armistead G. Russell, Anne M. Weaver, Erik Slawsky, Radhika Dhingra, Lydia Coulter Kwee, Rong Jiang, et al. “Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.Aging (Albany NY) 12, no. 23 (December 7, 2020): 24141–55. https://doi.org/10.18632/aging.202341.
Ward-Caviness CK, Russell AG, Weaver AM, Slawsky E, Dhingra R, Kwee LC, et al. Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution. Aging (Albany NY). 2020 Dec 7;12(23):24141–55.
Ward-Caviness, Cavin K., et al. “Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.Aging (Albany NY), vol. 12, no. 23, Dec. 2020, pp. 24141–55. Pubmed, doi:10.18632/aging.202341.
Ward-Caviness CK, Russell AG, Weaver AM, Slawsky E, Dhingra R, Kwee LC, Jiang R, Neas LM, Diaz-Sanchez D, Devlin RB, Cascio WE, Olden K, Hauser ER, Shah SH, Kraus WE. Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution. Aging (Albany NY). 2020 Dec 7;12(23):24141–24155.

Published In

Aging (Albany NY)

DOI

EISSN

1945-4589

Publication Date

December 7, 2020

Volume

12

Issue

23

Start / End Page

24141 / 24155

Location

United States

Related Subject Headings

  • Vehicle Emissions
  • Urban Health
  • Traffic-Related Pollution
  • Risk Assessment
  • Residence Characteristics
  • Peripheral Arterial Disease
  • North Carolina
  • Middle Aged
  • Male
  • Humans