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A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic.

Publication ,  Journal Article
Ward-Caviness, CK; Neas, LM; Blach, C; Haynes, CS; LaRocque-Abramson, K; Grass, E; Dowdy, ZE; Devlin, RB; Diaz-Sanchez, D; Cascio, WE; Shah, SH ...
Published in: PLoS One
2017

Air pollution is a worldwide contributor to cardiovascular disease mortality and morbidity. Traffic-related air pollution is a widespread environmental exposure and is associated with multiple cardiovascular outcomes such as coronary atherosclerosis, peripheral arterial disease, and myocardial infarction. Despite the recognition of the importance of both genetic and environmental exposures to the pathogenesis of cardiovascular disease, studies of how these two contributors operate jointly are rare. We performed a genome-wide interaction study (GWIS) to examine gene-traffic exposure interactions associated with coronary atherosclerosis. Using race-stratified cohorts of 538 African-Americans (AA) and 1562 European-Americans (EA) from a cardiac catheterization cohort (CATHGEN), we identify gene-by-traffic exposure interactions associated with the number of significantly diseased coronary vessels as a measure of chronic atherosclerosis. We found five suggestive (P<1x10-5) interactions in the AA GWIS, of which two (rs1856746 and rs2791713) replicated in the EA cohort (P < 0.05). Both SNPs are in the PIGR-FCAMR locus and are eQTLs in lymphocytes. The protein products of both PIGR and FCAMR are implicated in inflammatory processes. In the EA GWIS, there were three suggestive interactions; none of these replicated in the AA GWIS. All three were intergenic; the most significant interaction was in a regulatory region associated with SAMSN1, a gene previously associated with atherosclerosis and B cell activation. In conclusion, we have uncovered several novel genes associated with coronary atherosclerosis in individuals chronically exposed to increased ambient concentrations of traffic air pollution. These genes point towards inflammatory pathways that may modify the effects of air pollution on cardiovascular disease risk.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2017

Volume

12

Issue

3

Start / End Page

e0173880

Location

United States

Related Subject Headings

  • White People
  • Vehicle Emissions
  • Receptors, Fc
  • Receptors, Cell Surface
  • Quantitative Trait Loci
  • Middle Aged
  • Membrane Proteins
  • Male
  • Lymphocytes
  • Lymphocyte Activation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ward-Caviness, C. K., Neas, L. M., Blach, C., Haynes, C. S., LaRocque-Abramson, K., Grass, E., … Hauser, E. R. (2017). A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic. PLoS One, 12(3), e0173880. https://doi.org/10.1371/journal.pone.0173880
Ward-Caviness, Cavin K., Lucas M. Neas, Colette Blach, Carol S. Haynes, Karen LaRocque-Abramson, Elizabeth Grass, Z Elaine Dowdy, et al. “A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic.PLoS One 12, no. 3 (2017): e0173880. https://doi.org/10.1371/journal.pone.0173880.
Ward-Caviness, Cavin K., et al. “A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic.PLoS One, vol. 12, no. 3, 2017, p. e0173880. Pubmed, doi:10.1371/journal.pone.0173880.
Ward-Caviness CK, Neas LM, Blach C, Haynes CS, LaRocque-Abramson K, Grass E, Dowdy ZE, Devlin RB, Diaz-Sanchez D, Cascio WE, Miranda ML, Gregory SG, Shah SH, Kraus WE, Hauser ER. A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic. PLoS One. 2017;12(3):e0173880.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2017

Volume

12

Issue

3

Start / End Page

e0173880

Location

United States

Related Subject Headings

  • White People
  • Vehicle Emissions
  • Receptors, Fc
  • Receptors, Cell Surface
  • Quantitative Trait Loci
  • Middle Aged
  • Membrane Proteins
  • Male
  • Lymphocytes
  • Lymphocyte Activation