Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Exposures to low-levels of fine particulate matter are associated with acute changes in heart rate variability, cardiac repolarization, and circulating blood lipids in coronary artery disease patients.

Publication ,  Journal Article
Mirowsky, JE; Carraway, MS; Dhingra, R; Tong, H; Neas, L; Diaz-Sanchez, D; Cascio, WE; Case, M; Crooks, JL; Hauser, ER; Dowdy, ZE; Kraus, WE ...
Published in: Environ Res
November 2022

Exposure to air pollution is a major risk factor for cardiovascular disease, disease risk factors, and mortality. Specifically, particulate matter (PM), and to some extent ozone, are contributors to these effects. In addition, exposures to these pollutants may be especially dangerous for susceptible populations. In this repeated-visit panel study, cardiovascular markers were collected from thirteen male participants with stable coronary artery disease. For 0-4 days prior to the health measurement collections, daily concentrations of fine PM (PM2.5) and ozone were obtained from local central monitoring stations located near the participant's homes. Then, single (PM2.5) and two-pollutant (PM2.5 and ozone) models were used to assess whether there were short-term changes in cardiovascular health markers. Per interquartile range increase in PM2.5, there were decrements in several heart rate variability metrics, including the standard deviation of the normal-to-normal intervals (lag 3, -5.8%, 95% confidence interval (CI) = -11.5, 0.3) and root-mean squared of successive differences (five day moving average, -8.1%, 95% CI = -15.0, -0.7). In addition, increases in PM2.5 were also associated with changes in P complexity (lag 1, 4.4%, 95% CI = 0.5, 8.5), QRS complexity (lag 1, 4.9%, 95% CI = 1.4, 8.5), total cholesterol (five day moving average, -2.1%, 95% CI = -4.1, -0.1), and high-density lipoprotein cholesterol (lag 2, -1.6%, 95% CI = -3.1, -0.1). Comparisons to our previously published work on ozone were conducted. We found that ozone affected inflammation and endothelial function, whereas PM2.5 influenced heart rate variability, repolarization, and lipids. All the health changes from these two studies were found at concentrations below the United States Environmental Protection Agency's National Ambient Air Quality Standards. Our results imply clear differences in the cardiovascular outcomes observed with exposure to the two ubiquitous air pollutants PM2.5 and ozone; this observation suggests different mechanisms of toxicity for these exposures.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Environ Res

DOI

EISSN

1096-0953

Publication Date

November 2022

Volume

214

Issue

Pt 1

Start / End Page

113768

Location

Netherlands

Related Subject Headings

  • United States
  • Toxicology
  • Particulate Matter
  • Ozone
  • Male
  • Lipids
  • Humans
  • Heart Rate
  • Environmental Exposure
  • Coronary Artery Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mirowsky, J. E., Carraway, M. S., Dhingra, R., Tong, H., Neas, L., Diaz-Sanchez, D., … Devlin, R. B. (2022). Exposures to low-levels of fine particulate matter are associated with acute changes in heart rate variability, cardiac repolarization, and circulating blood lipids in coronary artery disease patients. Environ Res, 214(Pt 1), 113768. https://doi.org/10.1016/j.envres.2022.113768
Mirowsky, Jaime E., Martha Sue Carraway, Radhika Dhingra, Haiyan Tong, Lucas Neas, David Diaz-Sanchez, Wayne E. Cascio, et al. “Exposures to low-levels of fine particulate matter are associated with acute changes in heart rate variability, cardiac repolarization, and circulating blood lipids in coronary artery disease patients.Environ Res 214, no. Pt 1 (November 2022): 113768. https://doi.org/10.1016/j.envres.2022.113768.
Mirowsky JE, Carraway MS, Dhingra R, Tong H, Neas L, Diaz-Sanchez D, Cascio WE, Case M, Crooks JL, Hauser ER, Dowdy ZE, Kraus WE, Devlin RB. Exposures to low-levels of fine particulate matter are associated with acute changes in heart rate variability, cardiac repolarization, and circulating blood lipids in coronary artery disease patients. Environ Res. 2022 Nov;214(Pt 1):113768.
Journal cover image

Published In

Environ Res

DOI

EISSN

1096-0953

Publication Date

November 2022

Volume

214

Issue

Pt 1

Start / End Page

113768

Location

Netherlands

Related Subject Headings

  • United States
  • Toxicology
  • Particulate Matter
  • Ozone
  • Male
  • Lipids
  • Humans
  • Heart Rate
  • Environmental Exposure
  • Coronary Artery Disease