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Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.

Publication ,  Journal Article
Bihlmeyer, NA; Kwee, LC; Clish, CB; Deik, AA; Gerszten, RE; Pagidipati, NJ; Laferrère, B; Svetkey, LP; Newgard, CB; Kraus, WE; Shah, SH
Published in: PLoS One
2021

Obesity is an epidemic internationally. While weight loss interventions are efficacious, they are compounded by heterogeneity with regards to clinically relevant metabolic responses. Thus, we sought to identify metabolic biomarkers that are associated with beneficial metabolic changes to weight loss and which distinguish individuals with obesity who would most benefit from a given type of intervention. Liquid chromatography mass spectrometry-based profiling was used to measure 765 metabolites in baseline plasma from three different weight loss studies: WLM (behavioral intervention, N = 443), STRRIDE-PD (exercise intervention, N = 163), and CBD (surgical cohort, N = 125). The primary outcome was percent change in insulin resistance (as measured by the Homeostatic Model Assessment of Insulin Resistance [%ΔHOMA-IR]) over the intervention. Overall, 92 individual metabolites were associated with %ΔHOMA-IR after adjustment for multiple comparisons. Concordantly, the most significant metabolites were triacylglycerols (TAGs; p = 2.3e-5) and diacylglycerols (DAGs; p = 1.6e-4), with higher baseline TAG and DAG levels associated with a greater improvement in insulin resistance with weight loss. In tests of heterogeneity, 50 metabolites changed differently between weight loss interventions; we found amino acids, peptides, and their analogues to be most significant (4.7e-3) in this category. Our results highlight novel metabolic pathways associated with heterogeneity in response to weight loss interventions, and related biomarkers which could be used in future studies of personalized approaches to weight loss interventions.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2021

Volume

16

Issue

5

Start / End Page

e0240764

Location

United States

Related Subject Headings

  • Weight Loss
  • Triglycerides
  • Obesity
  • Middle Aged
  • Metabolomics
  • Mass Spectrometry
  • Male
  • Lipids
  • Lipid Metabolism
  • Insulin Resistance
 

Citation

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ICMJE
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Bihlmeyer, N. A., Kwee, L. C., Clish, C. B., Deik, A. A., Gerszten, R. E., Pagidipati, N. J., … Shah, S. H. (2021). Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions. PLoS One, 16(5), e0240764. https://doi.org/10.1371/journal.pone.0240764
Bihlmeyer, Nathan A., Lydia Coulter Kwee, Clary B. Clish, Amy Anderson Deik, Robert E. Gerszten, Neha J. Pagidipati, Blandine Laferrère, et al. “Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.PLoS One 16, no. 5 (2021): e0240764. https://doi.org/10.1371/journal.pone.0240764.
Bihlmeyer NA, Kwee LC, Clish CB, Deik AA, Gerszten RE, Pagidipati NJ, et al. Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions. PLoS One. 2021;16(5):e0240764.
Bihlmeyer, Nathan A., et al. “Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.PLoS One, vol. 16, no. 5, 2021, p. e0240764. Pubmed, doi:10.1371/journal.pone.0240764.
Bihlmeyer NA, Kwee LC, Clish CB, Deik AA, Gerszten RE, Pagidipati NJ, Laferrère B, Svetkey LP, Newgard CB, Kraus WE, Shah SH. Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions. PLoS One. 2021;16(5):e0240764.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2021

Volume

16

Issue

5

Start / End Page

e0240764

Location

United States

Related Subject Headings

  • Weight Loss
  • Triglycerides
  • Obesity
  • Middle Aged
  • Metabolomics
  • Mass Spectrometry
  • Male
  • Lipids
  • Lipid Metabolism
  • Insulin Resistance