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Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan.

Publication ,  Journal Article
Belsky, DW; Caspi, A; Cohen, HJ; Kraus, WE; Ramrakha, S; Poulton, R; Moffitt, TE
Published in: Aging Cell
August 2017

Therapies to extend healthspan are poised to move from laboratory animal models to human clinical trials. Translation from mouse to human will entail challenges, among them the multifactorial heterogeneity of human aging. To inform clinical trials about this heterogeneity, we report how humans' pace of biological aging relates to personal-history characteristics. Because geroprotective therapies must be delivered by midlife to prevent age-related disease onset, we studied young-adult members of the Dunedin Study 1972-73 birth cohort (n = 954). Cohort members' Pace of Aging was measured as coordinated decline in the integrity of multiple organ systems, by quantifying rate of decline across repeated measurements of 18 biomarkers assayed when cohort members were ages 26, 32, and 38 years. The childhood personal-history characteristics studied were known predictors of age-related disease and mortality, and were measured prospectively during childhood. Personal-history characteristics of familial longevity, childhood social class, adverse childhood experiences, and childhood health, intelligence, and self-control all predicted differences in cohort members' adulthood Pace of Aging. Accumulation of more personal-history risks predicted faster Pace of Aging. Because trials of anti-aging therapies will need to ascertain personal histories retrospectively, we replicated results using cohort members' retrospective personal-history reports made in adulthood. Because many trials recruit participants from clinical settings, we replicated results in the cohort subset who had recent health system contact according to electronic medical records. Quick, inexpensive measures of trial participants' early personal histories can enable clinical trials to study who volunteers for trials, who adheres to treatment, and who responds to anti-aging therapies.

Duke Scholars

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Published In

Aging Cell

DOI

EISSN

1474-9726

Publication Date

August 2017

Volume

16

Issue

4

Start / End Page

644 / 651

Location

England

Related Subject Headings

  • Social Class
  • Risk Factors
  • Patient Selection
  • Models, Animal
  • Medical History Taking
  • Longitudinal Studies
  • Life History Traits
  • Life Change Events
  • Humans
  • Healthy Lifestyle
 

Citation

APA
Chicago
ICMJE
MLA
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Belsky, D. W., Caspi, A., Cohen, H. J., Kraus, W. E., Ramrakha, S., Poulton, R., & Moffitt, T. E. (2017). Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan. Aging Cell, 16(4), 644–651. https://doi.org/10.1111/acel.12591
Belsky, Daniel W., Avshalom Caspi, Harvey J. Cohen, William E. Kraus, Sandhya Ramrakha, Richie Poulton, and Terrie E. Moffitt. “Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan.Aging Cell 16, no. 4 (August 2017): 644–51. https://doi.org/10.1111/acel.12591.
Belsky DW, Caspi A, Cohen HJ, Kraus WE, Ramrakha S, Poulton R, et al. Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan. Aging Cell. 2017 Aug;16(4):644–51.
Belsky, Daniel W., et al. “Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan.Aging Cell, vol. 16, no. 4, Aug. 2017, pp. 644–51. Pubmed, doi:10.1111/acel.12591.
Belsky DW, Caspi A, Cohen HJ, Kraus WE, Ramrakha S, Poulton R, Moffitt TE. Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan. Aging Cell. 2017 Aug;16(4):644–651.
Journal cover image

Published In

Aging Cell

DOI

EISSN

1474-9726

Publication Date

August 2017

Volume

16

Issue

4

Start / End Page

644 / 651

Location

England

Related Subject Headings

  • Social Class
  • Risk Factors
  • Patient Selection
  • Models, Animal
  • Medical History Taking
  • Longitudinal Studies
  • Life History Traits
  • Life Change Events
  • Humans
  • Healthy Lifestyle