Overview
William H. Majoros, PhD, is an Assistant Professor of Biostatistics and Bioinformatics.
Current Appointments & Affiliations
Assistant Professor of Biostatistics & Bioinformatics
·
2021 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Recent Publications
Characterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using CLEANSER.
Journal Article Cell Genom · February 12, 2025 Single-cell RNA sequencing CRISPR (perturb-seq) screens enable high-throughput investigation of the genome, allowing for characterization of thousands of genomic perturbations on gene expression. Ambient gRNAs, which are contaminating gRNAs, are a major so ... Full text Link to item CiteBayesian Estimation of Allele-Specific Expression in the Presence of Phasing Uncertainty.
Journal Article bioRxiv · August 13, 2024 MOTIVATION: Allele-specific expression (ASE) analyses aim to detect imbalanced expression of maternal versus paternal copies of an autosomal gene. Such allelic imbalance can result from a variety of cis-acting causes, including disruptive mutations within ... Full text Link to item CiteFull-length dystrophin restoration via targeted exon integration by AAV-CRISPR in a humanized mouse model of Duchenne muscular dystrophy.
Journal Article Mol Ther · November 3, 2021 Targeted gene-editing strategies have emerged as promising therapeutic approaches for the permanent treatment of inherited genetic diseases. However, precise gene correction and insertion approaches using homology-directed repair are still limited by low e ... Full text Link to item CiteRecent Grants
Computational Methods for Investigating the Genetics of Gene Regulation
ResearchPrincipal Investigator · Awarded by National Institute of General Medical Sciences · 2023 - 2028Design, prediction, and prioritization of systematic perturbations of the human genome
ResearchCo-Principal Investigator · Awarded by National Human Genome Research Institute · 2021 - 2026High-Throughput Functional Annotation of Gene Regulatory Elements and Variants Critical to Complex Cellular Phenotypes
ResearchCo Investigator · Awarded by National Institutes of Health · 2021 - 2026View All Grants
Education, Training & Certifications
Duke University ·
2017
Ph.D.