https://orcid.org/0000-0001-7284-9335
Overview
William H. Majoros, PhD, is an Assistant Professor of Biostatistics and Bioinformatics.
Current Duke Appointments & Affiliations
Assistant Professor of Biostatistics & Bioinformatics
·
2021 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Assistant Professor of Computer Science
·
2026 - Present
Computer Science,
Trinity College of Arts & Sciences
Recent Scholarly Works
Probabilistic mapping of sub-genic intolerance reveals functional and disease-critical protein regions.
Preprint · September 16, 2026 Different regions of genes perform distinct functions and vary in their importance to human health. Evolutionary intolerance provides a powerful means of identifying regions where disruptive mutations are under strong purifying selection, informing genetic ... Full text Link to item CiteStructured Pooling Improves Detection of Rare Regulatory Mutations in Population-Scale Reporter Assays.
Preprint · March 31, 2026 Identifying genetic variants in noncoding DNA that impact gene expression and thereby contribute to disease risk remains a difficult but important challenge in genomic medicine. Modern reporter assays such as STARR-seq and MPRA provide an efficient and eff ... Full text Link to item CiteIdentifying Inheritance Patterns of Allelic Imbalance, using Integrative Modeling and Bayesian Inference.
Preprint · March 31, 2026 Interpreting the effects of novel mutations on phenotypic traits remains challenging, particularly for cis -regulatory variants. For rare variants, individuals typically possess at most one affected copy of the causal allele, leading to allelic imbalance, ... Full text Link to item CiteRecent Grants
Computational Biology and Bioinformatics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031Computational Methods for Investigating the Genetics of Gene Regulation
ResearchPrincipal Investigator · Awarded by National Institute of General Medical Sciences · 2023 - 2028Design, prediction, and prioritization of systematic perturbations of the human genome
ResearchCo-Principal Investigator · Awarded by National Human Genome Research Institute · 2021 - 2027View All Grants
Education
Duke University ·
2017
Ph.D.