Scholars@Duke
Winston Clive Victor Parris

Winston Clive Victor Parris

Professor Emeritus of Anesthesiology
Anesthesiology, Pain Management
winston.parris@duke.edu
Box 3094 Med Ctr, Durham, NC 27710
932 Morrene Road, Durham, NC 27710
Manage Profile
Embed Profile Data

Selected Publications

Serial cerebrospinal fluid tryptophan and 5-hydroxy indoleacetic acid concentrations in healthy human subjects.

Journal Article Life Sci · August 23, 2002 The role of the serotonergic system in the pathogenesis of behavioral disorders such as depression, alcoholism, obsessive-compulsive disorder, and violence is not completely understood. Measurement of the concentration of neurotransmitters and their metabo ... Full text Link to item Cite

Chronic pain - The state of the art

Journal Article Nowotwory · January 1, 2000 The author discusses the modern approach to pain treatment quoting the opinion of Bonica concerning the need for a multidisciplinary approach to pain management. The paper presents the outline of modern methods, such as controlled-release opioids, implanta ... Cite

Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans.

Journal Article J Clin Psychopharmacol · December 1999 This study sought to examine the feasibility of prolonged assessment of acetylcholinesterase (AChE) activity in the cerebrospinal fluid (CSF) of volunteers and to test the hypothesis that rivastigmine (ENA-713; Exelon, Novartis Pharma AG, Basel, Switzerlan ... Full text Link to item Cite

The use of controlled-release oxycodone for the treatment of chronic cancer pain: a randomized, double-blind study.

Journal Article J Pain Symptom Manage · October 1998 To compare the effectiveness and safety of controlled-release (CR) oxycodone tablets with immediate-release (IR) oxycodone in patients with chronic cancer pain, a multicenter, randomized, double-blind, parallel-group study was performed in 111 patients wit ... Full text Link to item Cite

Comparison of controlled-release and immediate-release oxycodone tablets in patients with cancer pain.

Journal Article J Clin Oncol · October 1998 PURPOSE: This study compared the clinical efficacy of oxycodone hydrochloride controlled-release (CR) tablets administered every 12 hours with immediate-release (IR) oxycodone tablets administered four times daily in patients with cancer-related pain. PATI ... Full text Link to item Cite

President's message

Journal Article Pain Clinic · January 1, 1998 Cite

Long-term administration of controlled-release oxycodone tablets for the treatment of cancer pain.

Journal Article Cancer Invest · 1998 We conducted a study of the safety of controlled-release (CR) oxycodone tablets (OxyContin Tablets) administered chronically to patients with cancer-related pain in a usual clinical setting. These patients had participated in 1 of 2 double-blind, active-co ... Full text Link to item Cite

Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat.

Journal Article Can J Anaesth · August 1996 PURPOSE: The study compared analgesic efficacy of intrathecally administered ketorolac tromethamine (K) and morphine hydrochloride (M) (in equimolar doses) in the chronic neuropathic pain model, induced by chronic constriction injury (CCI) of the sciatic n ... Full text Link to item Cite

Persistent pain associated with long-term intrathecal morphine administration.

Journal Article South Med J · April 1996 A 32-year-old man with chronic intractable right lower extremity pain unresponsive to multiple neurosurgical and pharmacologic treatments, including intrathecal morphine administration, was successfully treated with sciatic nerve block, discontinuance of o ... Full text Link to item Cite

The importance of a multidisciplinary approach to pain management

Journal Article Pain Digest · March 1, 1996 Cite

Common chronic pain syndromes

Journal Article Pain Digest · March 1, 1996 Cite

Post-traumatic stress disorder in chronic pain patients

Journal Article Pain Digest · January 1, 1996 Post-traumatic stress disorder is likely underdiagnosed in persons with chronic pain, although a substantial number of patients seen in any pain clinic may suffer from this disorder. The relationship between post-traumatic stress disorder and chronic pain ... Cite

Perspectives of chronic pain management: Present and future

Journal Article Pain Digest · January 1, 1996 Cite

Infrared laser diode irradiation has no behavioral or biochemical effect on pain in the sciatic nerve ligation-induced mononeuropathy in rat.

Journal Article Anesth Prog · 1994 The aim of this study was to evaluate the effect of acute and repeated (5 days) treatment with various types of infrared (IR) diode lasers and probes (single- vs cluster-beam) on the pain response in rats with peripheral mononeuropathy produced by sciatic ... Link to item Cite

Anterior spinal artery syndrome?

Journal Article Anesthesiology · November 1993 Link to item Cite

Serial cerebrospinal fluid tryptophan and 5-hydroxy indoleacetic acid concentrations in healthy human subjects.

Journal Article Life Sci · August 23, 2002 The role of the serotonergic system in the pathogenesis of behavioral disorders such as depression, alcoholism, obsessive-compulsive disorder, and violence is not completely understood. Measurement of the concentration of neurotransmitters and their metabo ... Full text Link to item Cite

Chronic pain - The state of the art

Journal Article Nowotwory · January 1, 2000 The author discusses the modern approach to pain treatment quoting the opinion of Bonica concerning the need for a multidisciplinary approach to pain management. The paper presents the outline of modern methods, such as controlled-release opioids, implanta ... Cite

Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans.

Journal Article J Clin Psychopharmacol · December 1999 This study sought to examine the feasibility of prolonged assessment of acetylcholinesterase (AChE) activity in the cerebrospinal fluid (CSF) of volunteers and to test the hypothesis that rivastigmine (ENA-713; Exelon, Novartis Pharma AG, Basel, Switzerlan ... Full text Link to item Cite

The use of controlled-release oxycodone for the treatment of chronic cancer pain: a randomized, double-blind study.

Journal Article J Pain Symptom Manage · October 1998 To compare the effectiveness and safety of controlled-release (CR) oxycodone tablets with immediate-release (IR) oxycodone in patients with chronic cancer pain, a multicenter, randomized, double-blind, parallel-group study was performed in 111 patients wit ... Full text Link to item Cite

Comparison of controlled-release and immediate-release oxycodone tablets in patients with cancer pain.

Journal Article J Clin Oncol · October 1998 PURPOSE: This study compared the clinical efficacy of oxycodone hydrochloride controlled-release (CR) tablets administered every 12 hours with immediate-release (IR) oxycodone tablets administered four times daily in patients with cancer-related pain. PATI ... Full text Link to item Cite

President's message

Journal Article Pain Clinic · January 1, 1998 Cite

Long-term administration of controlled-release oxycodone tablets for the treatment of cancer pain.

Journal Article Cancer Invest · 1998 We conducted a study of the safety of controlled-release (CR) oxycodone tablets (OxyContin Tablets) administered chronically to patients with cancer-related pain in a usual clinical setting. These patients had participated in 1 of 2 double-blind, active-co ... Full text Link to item Cite

Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat.

Journal Article Can J Anaesth · August 1996 PURPOSE: The study compared analgesic efficacy of intrathecally administered ketorolac tromethamine (K) and morphine hydrochloride (M) (in equimolar doses) in the chronic neuropathic pain model, induced by chronic constriction injury (CCI) of the sciatic n ... Full text Link to item Cite

Persistent pain associated with long-term intrathecal morphine administration.

Journal Article South Med J · April 1996 A 32-year-old man with chronic intractable right lower extremity pain unresponsive to multiple neurosurgical and pharmacologic treatments, including intrathecal morphine administration, was successfully treated with sciatic nerve block, discontinuance of o ... Full text Link to item Cite

The importance of a multidisciplinary approach to pain management

Journal Article Pain Digest · March 1, 1996 Cite

Common chronic pain syndromes

Journal Article Pain Digest · March 1, 1996 Cite

Post-traumatic stress disorder in chronic pain patients

Journal Article Pain Digest · January 1, 1996 Post-traumatic stress disorder is likely underdiagnosed in persons with chronic pain, although a substantial number of patients seen in any pain clinic may suffer from this disorder. The relationship between post-traumatic stress disorder and chronic pain ... Cite

Perspectives of chronic pain management: Present and future

Journal Article Pain Digest · January 1, 1996 Cite

Infrared laser diode irradiation has no behavioral or biochemical effect on pain in the sciatic nerve ligation-induced mononeuropathy in rat.

Journal Article Anesth Prog · 1994 The aim of this study was to evaluate the effect of acute and repeated (5 days) treatment with various types of infrared (IR) diode lasers and probes (single- vs cluster-beam) on the pain response in rats with peripheral mononeuropathy produced by sciatic ... Link to item Cite

Anterior spinal artery syndrome?

Journal Article Anesthesiology · November 1993 Link to item Cite

Immunoreactive substance P in human saliva. A possible marker of chronic pain.

Journal Article Ann N Y Acad Sci · September 20, 1993 In all patients and volunteers, the levels of immunoreactive SP measured in saliva were about 100 times higher than the levels measured in plasma. SP per mg protein was consistently lower in both plasma and saliva of chronic pain patients than in healthy v ... Full text Link to item Cite

Early detection measures and triage procedures for suicide ideation in chronic pain patients.

Journal Article Clin J Pain · June 1992 There is a dearth of writings about early detection of potential suicide patients in chronic pain centers. Early detection measures used at the Vanderbilt Pain Control Center include a Symptom Checklist-90, with questions about depressive symptomatology an ... Full text Link to item Cite

Anaesthesia for laparoscopic cholecystectomy.

Journal Article Anaesthesia · November 1991 Full text Link to item Cite

Somatosensory evoked potentials are unchanged by reflex sympathetic dystrophy and by stellate ganglion block.

Journal Article Clin J Pain · September 1991 Median nerve somatosensory evoked potentials (SEPs) were monitored in patients with chronic pain before and after stellate ganglion blockade. A change caused by the syndrome or by the block would suggest that SEPs might be useful in the diagnosis and treat ... Full text Link to item Cite

The effects of neurokinin A, neurokinin B, and eledoisin on substance P analysis.

Journal Article J Clin Monit · April 1991 Commercial sources for neuropeptide radioimmunoassays have made this sensitive tool available to clinical investigators for monitoring the potential involvement of neuropeptides in pain modulation. We measured substance P-like immunoreactivity in the plasm ... Full text Link to item Cite

The relationship between cigarette smoking and chronic low back pain.

Journal Article Addict Behav · 1991 This study investigated the extent to which habitual cigarette smoking relates to physical and psychological indices of chronic pain. From a review of patient records, 54% of back pain patients referred for treatment of their pain admitted to smoking cigar ... Full text Link to item Cite

In vitro effects of fluoride and bromide on pseudocholinesterase and acetylcholinesterase activities.

Journal Article Can J Anaesth · November 1990 The in vitro effects of two metabolites of inhalational anaesthetics, fluoride and bromide, on pseudocholinesterase (PCHE) and acetylcholinesterase (ACHE) activities in the blood samples of seven healthy patients were studied. The PCHE and ACHE activities ... Full text Link to item Cite

Effects of significant weight gain on chronic pain patients.

Journal Article Clin J Pain · March 1990 This study examined the effect of significant weight gain on physical, demographic, behavioral, and psychosocial factors in a representative sample of chronic pain patients. One hundred fifty-five chronic pain patients who reported gaining more than 15 pou ... Full text Link to item Cite

Suprascapular nerve block: a safer technique.

Journal Article Anesthesiology · March 1990 Full text Link to item Cite

Immunoreactive substance P is decreased in saliva of patients with chronic back pain syndromes.

Journal Article Anesth Analg · January 1990 Substance P, a neuropeptide associated with pain perception, is widely distributed in the central nervous system and is decreased in the cerebrospinal fluid of chronic pain patients as compared with that of healthy human volunteers. In this study, we have ... Full text Link to item Cite

Substance P, acetylcholinesterase, and β-endorphin levels in the plasma and pericardial fluid of patients with and without angina pectoris

Journal Article Journal of Laboratory and Clinical Medicine · 1990 We measured substance P-like immunoreactivity (SPLI), β-endorphin-like immunoreactivity (BELI), acetylcholinesterase activity, and total protein content in pericardial fluid and plasma of patients with angina pectoris and patients with no angina pectoris. ... Cite

The influence of physical and psychosocial factors on accuracy of memory for pain in chronic pain patients.

Journal Article Pain · June 1989 Pain patients' retrospective reports of pain are important to physicians and other health professionals in helping to decide on future treatment plans. Unfortunately patients' memory of pain can be inaccurate and subject to overestimation. This study exami ... Full text Link to item Cite

Pseudocholinesterase activity in human cerebrospinal fluid.

Journal Article Anesth Analg · April 1989 Pseudocholinesterase (PCHE) activity and dibucaine numbers (DN) in the cerebrospinal fluid (CSF) and plasma of 10 ASA physical status 1 and 2 patients were measured using a kinetic method. CSF had a mean PCHE activity of 0.018 +/- 0.013 unit/ml with a DN o ... Link to item Cite

Reverse Sellick maneuver.

Journal Article Anesth Analg · March 1989 Full text Link to item Cite

Intrapleural analgesia for post-thoracotomy pain and blood levels of bupivacaine following intrapleural injection.

Journal Article Can J Anaesth · March 1989 An epidural type catheter was placed in the pleural space under direct vision before the closure of the chest in 24 patients who underwent thoracotomy for various types of lung or aortic surgery. All patients received intrapleural injections of 20 ml of 0. ... Full text Link to item Cite

Metoclopramide inhibits plasma cholinesterase

Journal Article Canadian Journal of Anaesthesia · 1989 Cite

Reply

Journal Article Canadian Journal of Anaesthesia · 1989 Full text Cite

Muscle atrophy following bupivacaine trigger point injection

Journal Article Anesthesiology Review · January 1, 1989 Cite

Treatment outcome in low back pain patients: do compensation benefits make a difference?

Journal Article Orthop Rev · December 1988 Some evidence suggests that chronic pain patients who receive worker's compensation benefits have a tendency to exaggerate their symptoms and not benefit from treatment. This study compared 110 male chronic low back pain patients receiving either no compen ... Link to item Cite

Effect of sevoflurane on P50 and on measurement of oxygen tension.

Journal Article J Clin Monit · October 1988 Fresh samples of heparinized human blood from 10 healthy nonsmoking volunteers were used to study the effect of the inhaled anesthetic sevoflurane on the oxygen half-saturation pressure of hemoglobin (P50) and on polarographic measurements of oxygen tensio ... Full text Link to item Cite

The inhibitory effect of metoclopramide on plasma cholinesterase activity.

Journal Article Can J Anaesth · September 1988 The in vitro effect of metoclopramide on plasma cholinesterase (PCHE) activity was studied to investigate a mechanism for metoclopramide-induced prolongation of succinylcholine action. The mean PCHE of the control samples was 0.86 +/- 0.02 unit.ml-1. PCHE ... Full text Link to item Cite

Muscle atrophy following nerve block therapy.

Journal Article Anesthesiology · August 1988 Full text Link to item Cite

Pre-treatment with somatostatin in the anaesthetic management of a patient with carcinoid syndrome.

Journal Article Can J Anaesth · July 1988 Carcinoid syndrome produces flushing, bronchoconstriction and gastrointestinal hypermotility secondary to serotonin, histamine, bradykinin and prostaglandin release. A variety of drugs, foods and anaesthetic agents may provoke this syndrome. Under anaesthe ... Full text Link to item Cite

Epidural blood patch in treatment of chronic headache

Journal Article Canadian Journal of Anaesthesia · May 1, 1988 Full text Cite

Empirically derived Symptom Checklist 90 subgroups of chronic pain patients: a cluster analysis.

Journal Article J Behav Med · April 1988 Four hundred fifty-three chronic pain patients completed a Symptom Checklist 90 (SCL-90) and a comprehensive pain evaluation questionnaire. All patients were evaluated by a physician and rated on degree of pain pathology and pain behavior. The SCL-90 data ... Full text Link to item Cite

Typical and atypical presentation of malignant hyperpyrexia in nonwhite patients.

Journal Article Anesth Prog · 1988 Two cases are presented of malignant hyperthermia in black patients. One patient developed signs of malignant hyperthermia during general anesthesia that was successfully treated with dantrolene sodium and cooling. A second patient was retrospectively diag ... Link to item Cite

Anxiety and postoperative recovery in ambulatory surgery patients.

Journal Article Anesth Prog · 1988 There has been a growing trend toward one-day ambulatory surgery. Unfortunately, there has been little research evaluating how patients recover at home after one-day surgery. This study examined the relationship between preoperative anxiety and postoperati ... Link to item Cite

The influence of problems with concentration and memory on emotional distress and daily activities in chronic pain patients.

Journal Article Int J Psychiatry Med · 1988 This study examined concentration and memory problems in chronic pain patients as they related to emotional distress and interference with daily activity. Three hundred and sixty-three chronic pain patients were divided into two groups based on how much th ... Full text Link to item Cite

The effect of intentional hemodilution on P50.

Journal Article J Cardiovasc Surg (Torino) · 1988 Ten patients (Group I) scheduled for major vascular surgery received banked blood and twelve patients (Group II) also scheduled for major vascular surgery were administered intentional hemodilution with autologous blood. Both groups of patients were studie ... Link to item Cite

Effects of time-limited vs unlimited compensation on pain behavior and treatment outcome in low back pain patients.

Journal Article J Psychosom Res · 1988 A common theme in the pain literature is that worker's compensation reinforces pain behavior and adversely influences treatment outcome of chronic pain patients. This study compared 110 chronic low back pain males divided into three groups: 44 receiving no ... Full text Link to item Cite

Use of epidural blood patch in treating chronic headache: report of six cases.

Journal Article Can J Anaesth · July 1987 Chronic headaches are difficult problems to manage effectively. A select group of six patients with headache symptoms (throbbing headaches, located in the frontal or occipital areas; aggravated by ambulation and relieved by recumbency) resembling post-dura ... Full text Link to item Cite

Chronic pain assessment using heat beam dolorimetry.

Journal Article Pain · July 1987 The heat beam dolorimeter (HBD) was developed to evaluate cutaneous pain thresholds in humans. In the present study, the hypothesis that a patient's underlying pain status affects his pain tolerance to an incident HBD stimulus was tested. Twenty-seven chro ... Full text Link to item Cite

Herpes zoster ophthalmicus associated with contralateral hemiplegia

Journal Article Clinical Journal of Pain · January 1, 1987 Herpes zoster occurs following a reactivation of dormant varicella virus, which produces neurogenic changes in the nerve roots of spinal and cranial nerves. The symptomatology that follows includes pain and vesicular eruptions over the affected dermatomes. ... Full text Cite

Anesthetic considerations for the patient with polymyositis

Journal Article Anesthesiology Review · January 1, 1987 Cite

Use of sensory descriptors in assessing chronic pain patients.

Journal Article J Psychosom Res · 1987 The present study examined the use of sensory descriptors in assessing chronic pain patients in a multidisciplinary treatment center. Three hundred and eighty-eight chronic pain patients were divided into two groups based on the number of pain sensations w ... Full text Link to item Cite

Chronic pain management: a logical approach.

Journal Article J Tenn Med Assoc · November 1986 Link to item Cite

Management of mastocytosis in pregnancy

Journal Article Anesthesiology Review · January 1, 1986 Cite

Nerve block therapy

Journal Article Clinics in Anaesthesiology · January 1, 1985 Cite

Management of post-herpetic neuralgia.

Journal Article J Tenn Med Assoc · October 1984 Link to item Cite

Anesthetic management in autonomic dysfunction

Journal Article Anesthesiology Review · January 1, 1984 Cite

Hazards in operative management of patients with systemic mastocytosis.

Journal Article Ann Surg · May 1983 During the past two years, six patients with systemic mastocytosis have required general or regional anesthesia for operative correction of various surgical problems. Mastocytosis constitutes an extremely difficult problem in diagnosis and management. A la ... Full text Link to item Cite

Tracheomegaly.

Journal Article Anesthesiology · February 1982 Full text Link to item Cite

Management of tetanus

Journal Article Anesthesiology Review · January 1, 1981 Cite

Anesthetic management of mastocytosis

Journal Article Anesthesiology Review · January 1, 1981 A case of mastocytosis scheduled for dilation and curettage and laparoscopic tubal ligation is presented. The patient was anesthetized uneventfully with enflurane, nitrous oxide and oxygen mixture. The various problems and precautions associated with the a ... Cite

Therapeutic angiography in renal transplant complications.

Journal Article Proc Clin Dial Transplant Forum · 1980 Link to item Cite