Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Pathology, The University of Chicago 2012 - 2013
  • Residency, Pathology, The University of Chicago 2008 - 2012
  • Research Fellow, Pathology, Harvard University 2003 - 2008
  • Doctoral Student, Pathology, Peking Union Medical College (China) 1998 - 2002
  • Residency, Pathology, Peking Union Medical College (China) 1995 - 1998
  • M.D., China Medical University (China) 1995
• 

  Duke Appointment History

  • Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2016 - 2019
  • Associate Professor of Pathology, Pathology, Clinical Science Departments 2018 - 2019
  • Assistant Professor of Pathology, Pathology, Clinical Science Departments 2013 - 2018
• Research
• 

  Selected Grants

  • HBV Clinical Research Network Site Application_Subcontract to UNC awarded by University of North Carolina - Chapel Hill 2015 - 2021
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Zhao, Lei, Liyan Xu, Amanda Hemmerich, N Lynn Ferguson, Cynthia D. Guy, Shannon J. McCall, Diana M. Cardona, et al. “Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility.” Virchows Arch 478, no. 3 (March 2021): 427–34. https://doi.org/10.1007/s00428-020-02925-2.
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    • Yin, Feng, Hao Xie, Jinping Lai, Yuanhong Chen, Jixin Dong, Xuefeng Zhang, and Xiuli Liu. “Double Negativity for Expression of YAP1 and CDX2 Defines an Aggressive Type of Colitis-associated Cancer.” Anticancer Res 40, no. 10 (October 2020): 5411–16. https://doi.org/10.21873/anticanres.14550.
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    • Zhang, Dongwei, John Hart, Xianzhong Ding, Xuchen Zhang, Michael Feely, Lindsay Yassan, Lindsay Alpert, et al. “Histologic patterns of liver injury induced by anti-PD-1 therapy.” Gastroenterol Rep (Oxf) 8, no. 1 (February 2020): 50–55. https://doi.org/10.1093/gastro/goz044.
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    • Xu, Xinyuan, Danwen Qian, Hongliang Liu, Diana Cruz, Sheng Luo, Kyle M. Walsh, James L. Abbruzzese, Xuefeng Zhang, and Qingyi Wei. “Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.” Mol Carcinog 58, no. 8 (August 2019): 1338–48. https://doi.org/10.1002/mc.23018.
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    • Feng, Yun, Hongliang Liu, Bensong Duan, Zhensheng Liu, James Abbruzzese, Kyle M. Walsh, Xuefeng Zhang, and Qingyi Wei. “Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer.” Carcinogenesis 40, no. 4 (June 10, 2019): 521–28. https://doi.org/10.1093/carcin/bgz029.
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    • Yang, Wenjun, Hongliang Liu, Bensong Duan, Xinyuan Xu, Dennis Carmody, Sheng Luo, Kyle M. Walsh, et al. “Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk.” Cancer Sci 110, no. 6 (June 2019): 2022–32. https://doi.org/10.1111/cas.14017.
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    • Carney, John M., Lin Wang, Rex Bentley, Diana M. Cardona, and Xuefeng Zhang. “Metastatic squamous cell carcinoma with pseudoangiosarcomatous features and aberrant expression of vascular markers.” Pathol Res Pract 214, no. 10 (October 2018): 1732–37. https://doi.org/10.1016/j.prp.2018.06.006.
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    • Ma, Shuang, Siddhartha Sen Sen, Rachel Jug, Xuefeng Zhang, Wan-Lin Zhang, Shuai Shen, Cheng-Qian Yu, Hong-Tao Xu, Lian-He Yang, and Endi Wang. “Adrenal relapse of primary central nervous system diffuse large B-cell lymphoma: A case report.” Medicine (Baltimore) 97, no. 38 (September 2018): e12482. https://doi.org/10.1097/MD.0000000000012482.
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    • Ma, Shuang, Michael Schild, Diana Tran, Xuefeng Zhang, Wan-Lin Zhang, Shuai Shen, Hong-Tao Xu, Lian-He Yang, and Endi Wang. “Primary central nervous system histiocytic sarcoma: A case report and review of literature.” Medicine (Baltimore) 97, no. 26 (June 2018): e11271. https://doi.org/10.1097/MD.0000000000011271.
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    • Hemmerich, Amanda, Mohanad Shaar, Rebecca Burbridge, Cynthia D. Guy, Shannon J. McCall, Diana M. Cardona, Xuchen Zhang, Jinping Lai, and Xuefeng Zhang. “Metastatic Renal Cell Carcinoma as Solitary Subcentimeter Polypoid Gastric Mucosal Lesions: Clinicopathologic Analysis of Five Cases.” Gastroenterology Res 11, no. 1 (February 2018): 25–30. https://doi.org/10.14740/gr952w.
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    • Harrison, Grant, Amanda Hemmerich, Cynthia Guy, Kathryn Perkinson, Debra Fleming, Shannon McCall, Diana Cardona, and Xuefeng Zhang. “Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas.” Am J Clin Pathol 149, no. 1 (December 20, 2017): 67–75. https://doi.org/10.1093/ajcp/aqx142.
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    • Foo, Wen-Chi, Grant Harrison, and Xuefeng Zhang. “Immunocytochemistry for SOX-11 and TFE3 as diagnostic markers for solid pseudopapillary neoplasms of the pancreas in FNA biopsies.” Cancer Cytopathol 125, no. 11 (November 2017): 831–37. https://doi.org/10.1002/cncy.21931.
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    • Luedke, Catherine, Kadiyala Ravindra, Barbara Hertzberg, Carl Berg, Rex Bentley, and Xuefeng Zhang. “A Rapidly Enlarging Müllerian-Derived Hepatic Adenomyoma Clinically Mimicking Hepatic Adenoma in a Pregnant Woman.” Am J Gastroenterol 112, no. 8 (August 2017): 1217. https://doi.org/10.1038/ajg.2017.158.
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    • Patel, Yuval A., Shannon J. McCall, Xuefeng Zhang, Tracy Jaffe, and Rahul A. Shimpi. “Radiographic and endoscopic regression of metastatic gastric cancer to the colon in the setting of 5-aminosalicylic acid use.” J Gastrointest Oncol 7, no. 6 (December 2016): E88–92. https://doi.org/10.21037/jgo.2016.05.02.
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    • Ludmir, Ethan B., Shannon J. McCall, Diana M. Cardona, Kathryn R. Perkinson, Cynthia D. Guy, and Xuefeng Zhang. “Mixed Adenoneuroendocrine Carcinoma, Amphicrine Type, of the Small Bowel.” Am J Clin Pathol 145, no. 5 (May 2016): 703–9. https://doi.org/10.1093/ajcp/aqw028.
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    • Akthar, Adil S., Daniel W. Golden, Rita Nanda, Manish R. Sharma, Helen S. Te, K Gautham Reddy, Xuefeng Zhang, and Renuka Malik. “Early and Severe Radiation Esophagitis Associated With Concurrent Sirolimus.” Journal of Clinical Oncology 34, no. 9 (March 20, 2016): e73–75. https://doi.org/10.1200/jco.2013.50.1643.
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    • Zhang, Xuefeng, Maria Westerhoff, and John Hart. “Expression of SOX9 and CDX2 in nongoblet columnar-lined esophagus predicts the detection of Barrett's esophagus during follow-up.” Mod Pathol 28, no. 5 (May 2015): 654–61. https://doi.org/10.1038/modpathol.2014.157.
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    • Zhang, Xuefeng, Xiuli Liu, Loren Joseph, Lei Zhao, John Hart, and Shu-Yuan Xiao. “Pancreatic ductal adenocarcinoma with autoimmune pancreatitis-like histologic and immunohistochemical features.” Hum Pathol 45, no. 3 (March 2014): 621–27. https://doi.org/10.1016/j.humpath.2013.08.027.
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    • Ludmir, E. B., M. Palta, X. Zhang, Y. Wu, C. G. Willett, and B. G. Czito. “Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma.” Journal of Gastrointestinal Oncology 5, no. 6 (January 1, 2014): 401–7. https://doi.org/10.3978/j.issn.2078-6891.2014.05.
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    • Zhang, Xuefeng, Elizabeth Hyjek, and James Vardiman. “A subset of Rosai-Dorfman disease exhibits features of IgG4-related disease.” Am J Clin Pathol 139, no. 5 (May 2013): 622–32. https://doi.org/10.1309/AJCPARC3YQ0KLIOA.
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    • Zhang, Xuefeng, Elizabeth Hyjek, Keyoumars Soltani, Vesna Petronic-Rosic, and Christopher R. Shea. “Immunohistochemistry for immunoglobulin G4 on paraffin sections for the diagnosis of pemphigus.” Arch Pathol Lab Med 136, no. 11 (November 2012): 1402–7. https://doi.org/10.5858/arpa.2011-0425-OA.
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    • Gwin, Katja, Nicole Cipriani, Xuefeng Zhang, Robert Schmidt, and Elisabeth Hyjek. “Bilateral breast involvement by disseminated extranodal Rosai-Dorfman disease.” Breast J 17, no. 3 (May 2011): 309–11. https://doi.org/10.1111/j.1524-4741.2011.01072.x.
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    • Zhang, Xuefeng, Shideh Kazerounian, Mark Duquette, Carole Perruzzi, Janice A. Nagy, Harold F. Dvorak, Sareh Parangi, and Jack Lawler. “Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level.” Faseb J 23, no. 10 (October 2009): 3368–76. https://doi.org/10.1096/fj.09-131649.
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    • Ren, Bin, Keli Song, Sareh Parangi, Taiguang Jin, Min Ye, Robin Humphreys, Mark Duquette, et al. “A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR.” Cancer Res 69, no. 9 (May 1, 2009): 3856–65. https://doi.org/10.1158/0008-5472.CAN-08-2940.
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    • Zhang, Xuefeng, and Jack Lawler. “Thrombospondin-based antiangiogenic therapy.” Microvasc Res 74, no. 2–3 (September 2007): 90–99. https://doi.org/10.1016/j.mvr.2007.04.007.
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    • Zhang, Xuefeng, Jianfeng Xu, Jack Lawler, Ernest Terwilliger, and Sareh Parangi. “Adeno-associated virus-mediated antiangiogenic gene therapy with thrombospondin-1 type 1 repeats and endostatin.” Clin Cancer Res 13, no. 13 (July 1, 2007): 3968–76. https://doi.org/10.1158/1078-0432.CCR-07-0245.
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    • Zhang, Xuefeng, Caitlin Connolly, Mark Duquette, Jack Lawler, and Sareh Parangi. “Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model.” Cancer Lett 247, no. 1 (March 8, 2007): 143–49. https://doi.org/10.1016/j.canlet.2006.04.003.
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    • Zhang, Xuefeng, Eric Galardi, Mark Duquette, Jack Lawler, and Sareh Parangi. “Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model.” Clin Cancer Res 11, no. 15 (August 1, 2005): 5622–30. https://doi.org/10.1158/1078-0432.CCR-05-0459.
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    • Zhang, Xuefeng, Eric Galardi, Mark Duquette, Marko Delic, Jack Lawler, and Sareh Parangi. “Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model.” Clin Cancer Res 11, no. 6 (March 15, 2005): 2337–44. https://doi.org/10.1158/1078-0432.CCR-04-1900.
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