Scholars@Duke
Xuefeng Zhang

Xuefeng Zhang

Adjunct Associate Professor in the Department of Pathology
Pathology
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Selected Publications

Postinfantile Giant Cell Hepatitis in Native and Allograft Livers: A Multi-Institutional Clinicopathologic Study of 70 Cases.

Journal Article Mod Pathol · November 2023 Postinfantile giant cell hepatitis (PIGCH) is a rare hepatitis pattern in adults with variable etiologies and clinical outcomes. We conducted a multi-institutional retrospective study to define the clinicopathologic characteristics of patients with PIGCH. ... Full text Link to item Cite

Accuracy of Endoscopic Biopsies for Determining Tumor Grade in Pre-resection Evaluation of Esophageal Adenocarcinoma

Journal Article Techniques and Innovations in Gastrointestinal Endoscopy · January 1, 2023 Background and Aims: Endoscopic resection (ER) can be a curative treatment for early esophageal adenocarcinoma (EAC). Poor tumor differentiation is a histologic feature of noncurative ER and, when seen on preoperative biopsies, may lead to avoidance of end ... Full text Cite

Outcomes for endoscopic submucosal dissection of pathologically staged T1b esophageal cancer: a multicenter study.

Journal Article Gastrointest Endosc · September 2022 BACKGROUND AND AIMS: The outcomes of endoscopic submucosal dissection (ESD) for T1b esophageal cancer (EC) and its recurrence rates remain unclear in the West. Using a multicenter cohort, we evaluated technical outcomes and recurrence rates of ESD in the t ... Full text Link to item Cite

Prediction of neoplastic progression in Barrett's esophagus using nanoscale nuclear architecture mapping: a pilot study.

Journal Article Gastrointest Endosc · June 2022 BACKGROUND AND AIMS: Nanoscale nuclear architecture mapping (nanoNAM), an optical coherence tomography-derived approach, is capable of detecting with nanoscale sensitivity structural alterations in the chromatin of epithelial cell nuclei at risk for malign ... Full text Link to item Cite

Development of a Scoring System to Differentiate Amiodarone-Induced Liver Injury From Alcoholic Steatohepatitis.

Journal Article Am J Clin Pathol · March 3, 2022 OBJECTIVES: Amiodarone-induced liver injury (AILI) is histopathologically similar to alcoholic steatohepatitis (ASH). We sought to elucidate their histologic differences and develop a scoring system to differentiate these two entities. METHODS: A cohort of ... Full text Link to item Cite

Splenic-vasculature involvement is associated with poor prognosis in resected distal pancreatic cancer.

Journal Article Gastroenterol Rep (Oxf) · April 2021 BACKGROUND: Distal pancreatic carcinoma is one of the most lethal cancers largely due to its high incidence of distant metastasis. This study aims to assess the prognostic value of splenic-vasculature involvement in resected distal pancreatic carcinoma. ME ... Full text Link to item Cite

Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility.

Journal Article Virchows Arch · March 2021 The diagnosis of invasive adenocarcinoma of the gallbladder can sometimes be challenging. The presence of true desmoplastic reaction facilitates the diagnosis of invasion. However, desmoplasia-like changes can be observed in benign gallbladder conditions, ... Full text Link to item Cite

Double Negativity for Expression of YAP1 and CDX2 Defines an Aggressive Type of Colitis-associated Cancer.

Journal Article Anticancer Res · October 2020 BACKGROUND: Patients with inflammatory bowel disease have markedly increased risk for developing colitis-associated colorectal adenocarcinoma (CAC). There is no established prognostic biomarker for CAC. MATERIALS AND METHODS: A retrospective study was perf ... Full text Link to item Cite

Smooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases.

Journal Article Mod Pathol · July 2020 Smooth muscle tumors represent the second most common mural mesenchymal neoplasm in the gastrointestinal tract, but established criteria for prognostic assessment of these tumors are lacking. A large cohort of surgically resected intramural gastrointestina ... Full text Link to item Cite

Histologic patterns of liver injury induced by anti-PD-1 therapy.

Journal Article Gastroenterol Rep (Oxf) · February 2020 BACKGROUND: Nivolumab and pembrolizumab-two monoclonal antibodies that block human programmed cell death-1 (PD-1)-have been successfully used to treat patients with multiple advanced malignancies. The histologic patterns of hepatic toxicity induced by anti ... Full text Link to item Cite

Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.

Journal Article Mol Carcinog · August 2019 The liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) pathway has been identified as a new target for cancer therapy, because it controls the glucose and lipid metabolism in response to alterations in nutrients and intracellular energy levels. In th ... Full text Open Access Link to item Cite

Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer.

Journal Article Carcinogenesis · June 10, 2019 The AURORA pathway participates in mitosis and cell division, and alterations in mitosis and cell division can lead to carcinogenesis. Therefore, genetic variants in the AURORA pathway genes may be associated with susceptibility to pancreatic cancer. To te ... Full text Open Access Link to item Cite

Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk.

Journal Article Cancer Sci · June 2019 Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic PanC is often present at the time of diagnosis. Although several high- and low-penetrance genes have been implicated in PanC, their roles in carcinogenesis remain only pa ... Full text Open Access Link to item Cite

Metastatic squamous cell carcinoma with pseudoangiosarcomatous features and aberrant expression of vascular markers.

Journal Article Pathol Res Pract · October 2018 Squamous cell carcinoma with pseudoangiosarcomatous features is a rare but well-recognized variant of squamous cell carcinoma. These tumors exhibit complex anastomosing channels lined by neoplastic cells, histologically mimicking a vasoformative mesenchyma ... Full text Link to item Cite

Adrenal relapse of primary central nervous system diffuse large B-cell lymphoma: A case report.

Journal Article Medicine (Baltimore) · September 2018 RATIONALE: Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma with a dismal outcome. Most patients relapse in intracranial sites and <5% of patients relapse in extracranial sites. Here, we present the first case of PCNSL ... Full text Link to item Cite

Primary central nervous system histiocytic sarcoma: A case report and review of literature.

Journal Article Medicine (Baltimore) · June 2018 RATIONALE: Primary central nervous system histiocytic sarcoma (PCNSHS) is a rare lymphohematopoietic tumor with a histiocytic cell origin. To our knowledge, only 28 cases have been published in English and 2 cases in Chinese. PATIENT CONCERNS: A 49-year-ol ... Full text Link to item Cite

Metastatic Renal Cell Carcinoma as Solitary Subcentimeter Polypoid Gastric Mucosal Lesions: Clinicopathologic Analysis of Five Cases.

Journal Article Gastroenterology Res · February 2018 BACKGROUND: The stomach is an uncommon site for metastatic carcinoma. Approximately 6% of renal cell carcinomas (RCCs) may metastasize to the stomach. The majority of the reported metastatic RCCs in the stomach presented as large masses or ulcers greater t ... Full text Open Access Link to item Cite

Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas.

Journal Article Am J Clin Pathol · December 20, 2017 OBJECTIVES: To characterize the expression of SOX11 and TFE3 proteins in solid-pseudopapillary neoplasms (SPNs) and their histologic mimickers. METHODS: Immunohistochemistry for SOX11, TFE3, and β-catenin was performed on 31 cases of surgically resected SP ... Full text Link to item Cite

Postinfantile Giant Cell Hepatitis in Native and Allograft Livers: A Multi-Institutional Clinicopathologic Study of 70 Cases.

Journal Article Mod Pathol · November 2023 Postinfantile giant cell hepatitis (PIGCH) is a rare hepatitis pattern in adults with variable etiologies and clinical outcomes. We conducted a multi-institutional retrospective study to define the clinicopathologic characteristics of patients with PIGCH. ... Full text Link to item Cite

Accuracy of Endoscopic Biopsies for Determining Tumor Grade in Pre-resection Evaluation of Esophageal Adenocarcinoma

Journal Article Techniques and Innovations in Gastrointestinal Endoscopy · January 1, 2023 Background and Aims: Endoscopic resection (ER) can be a curative treatment for early esophageal adenocarcinoma (EAC). Poor tumor differentiation is a histologic feature of noncurative ER and, when seen on preoperative biopsies, may lead to avoidance of end ... Full text Cite

Outcomes for endoscopic submucosal dissection of pathologically staged T1b esophageal cancer: a multicenter study.

Journal Article Gastrointest Endosc · September 2022 BACKGROUND AND AIMS: The outcomes of endoscopic submucosal dissection (ESD) for T1b esophageal cancer (EC) and its recurrence rates remain unclear in the West. Using a multicenter cohort, we evaluated technical outcomes and recurrence rates of ESD in the t ... Full text Link to item Cite

Prediction of neoplastic progression in Barrett's esophagus using nanoscale nuclear architecture mapping: a pilot study.

Journal Article Gastrointest Endosc · June 2022 BACKGROUND AND AIMS: Nanoscale nuclear architecture mapping (nanoNAM), an optical coherence tomography-derived approach, is capable of detecting with nanoscale sensitivity structural alterations in the chromatin of epithelial cell nuclei at risk for malign ... Full text Link to item Cite

Development of a Scoring System to Differentiate Amiodarone-Induced Liver Injury From Alcoholic Steatohepatitis.

Journal Article Am J Clin Pathol · March 3, 2022 OBJECTIVES: Amiodarone-induced liver injury (AILI) is histopathologically similar to alcoholic steatohepatitis (ASH). We sought to elucidate their histologic differences and develop a scoring system to differentiate these two entities. METHODS: A cohort of ... Full text Link to item Cite

Splenic-vasculature involvement is associated with poor prognosis in resected distal pancreatic cancer.

Journal Article Gastroenterol Rep (Oxf) · April 2021 BACKGROUND: Distal pancreatic carcinoma is one of the most lethal cancers largely due to its high incidence of distant metastasis. This study aims to assess the prognostic value of splenic-vasculature involvement in resected distal pancreatic carcinoma. ME ... Full text Link to item Cite

Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility.

Journal Article Virchows Arch · March 2021 The diagnosis of invasive adenocarcinoma of the gallbladder can sometimes be challenging. The presence of true desmoplastic reaction facilitates the diagnosis of invasion. However, desmoplasia-like changes can be observed in benign gallbladder conditions, ... Full text Link to item Cite

Double Negativity for Expression of YAP1 and CDX2 Defines an Aggressive Type of Colitis-associated Cancer.

Journal Article Anticancer Res · October 2020 BACKGROUND: Patients with inflammatory bowel disease have markedly increased risk for developing colitis-associated colorectal adenocarcinoma (CAC). There is no established prognostic biomarker for CAC. MATERIALS AND METHODS: A retrospective study was perf ... Full text Link to item Cite

Smooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases.

Journal Article Mod Pathol · July 2020 Smooth muscle tumors represent the second most common mural mesenchymal neoplasm in the gastrointestinal tract, but established criteria for prognostic assessment of these tumors are lacking. A large cohort of surgically resected intramural gastrointestina ... Full text Link to item Cite

Histologic patterns of liver injury induced by anti-PD-1 therapy.

Journal Article Gastroenterol Rep (Oxf) · February 2020 BACKGROUND: Nivolumab and pembrolizumab-two monoclonal antibodies that block human programmed cell death-1 (PD-1)-have been successfully used to treat patients with multiple advanced malignancies. The histologic patterns of hepatic toxicity induced by anti ... Full text Link to item Cite

Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.

Journal Article Mol Carcinog · August 2019 The liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) pathway has been identified as a new target for cancer therapy, because it controls the glucose and lipid metabolism in response to alterations in nutrients and intracellular energy levels. In th ... Full text Open Access Link to item Cite

Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer.

Journal Article Carcinogenesis · June 10, 2019 The AURORA pathway participates in mitosis and cell division, and alterations in mitosis and cell division can lead to carcinogenesis. Therefore, genetic variants in the AURORA pathway genes may be associated with susceptibility to pancreatic cancer. To te ... Full text Open Access Link to item Cite

Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk.

Journal Article Cancer Sci · June 2019 Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic PanC is often present at the time of diagnosis. Although several high- and low-penetrance genes have been implicated in PanC, their roles in carcinogenesis remain only pa ... Full text Open Access Link to item Cite

Metastatic squamous cell carcinoma with pseudoangiosarcomatous features and aberrant expression of vascular markers.

Journal Article Pathol Res Pract · October 2018 Squamous cell carcinoma with pseudoangiosarcomatous features is a rare but well-recognized variant of squamous cell carcinoma. These tumors exhibit complex anastomosing channels lined by neoplastic cells, histologically mimicking a vasoformative mesenchyma ... Full text Link to item Cite

Adrenal relapse of primary central nervous system diffuse large B-cell lymphoma: A case report.

Journal Article Medicine (Baltimore) · September 2018 RATIONALE: Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma with a dismal outcome. Most patients relapse in intracranial sites and <5% of patients relapse in extracranial sites. Here, we present the first case of PCNSL ... Full text Link to item Cite

Primary central nervous system histiocytic sarcoma: A case report and review of literature.

Journal Article Medicine (Baltimore) · June 2018 RATIONALE: Primary central nervous system histiocytic sarcoma (PCNSHS) is a rare lymphohematopoietic tumor with a histiocytic cell origin. To our knowledge, only 28 cases have been published in English and 2 cases in Chinese. PATIENT CONCERNS: A 49-year-ol ... Full text Link to item Cite

Metastatic Renal Cell Carcinoma as Solitary Subcentimeter Polypoid Gastric Mucosal Lesions: Clinicopathologic Analysis of Five Cases.

Journal Article Gastroenterology Res · February 2018 BACKGROUND: The stomach is an uncommon site for metastatic carcinoma. Approximately 6% of renal cell carcinomas (RCCs) may metastasize to the stomach. The majority of the reported metastatic RCCs in the stomach presented as large masses or ulcers greater t ... Full text Open Access Link to item Cite

Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas.

Journal Article Am J Clin Pathol · December 20, 2017 OBJECTIVES: To characterize the expression of SOX11 and TFE3 proteins in solid-pseudopapillary neoplasms (SPNs) and their histologic mimickers. METHODS: Immunohistochemistry for SOX11, TFE3, and β-catenin was performed on 31 cases of surgically resected SP ... Full text Link to item Cite

Immunocytochemistry for SOX-11 and TFE3 as diagnostic markers for solid pseudopapillary neoplasms of the pancreas in FNA biopsies.

Journal Article Cancer Cytopathol · November 2017 BACKGROUND: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare malignant tumors that can be sampled via endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Although diagnosing SPNs can be straightforward in cases with a classic morp ... Full text Link to item Cite

Radiographic and endoscopic regression of metastatic gastric cancer to the colon in the setting of 5-aminosalicylic acid use.

Journal Article J Gastrointest Oncol · December 2016 Colonic metastases from gastric cancer are a rare phenomenon and sparsely reported in the literature. We report a case of a 59-year-old woman who presented with vague abdominal symptoms and initial computer tomography (CT) imaging suggestive of a colonic a ... Full text Link to item Cite

Mixed Adenoneuroendocrine Carcinoma, Amphicrine Type, of the Small Bowel.

Journal Article Am J Clin Pathol · May 2016 OBJECTIVES: Amphicrine-type mixed adenoneuroendocrine carcinomas are exceedingly rare lesions of the gastrointestinal tract, comprising tumor cells simultaneously demonstrating both neuroendocrine and exocrine features. To date, only 14 cases of amphicrine ... Full text Link to item Cite

Early and Severe Radiation Esophagitis Associated With Concurrent Sirolimus

Journal Article Journal of Clinical Oncology · March 20, 2016 Full text Cite

Expression of SOX9 and CDX2 in nongoblet columnar-lined esophagus predicts the detection of Barrett's esophagus during follow-up.

Journal Article Mod Pathol · May 2015 The diagnosis of Barrett's esophagus in the United States requires both endoscopically evident columnar-lined esophagus and the presence of goblet cells by histology. Currently, there is no consensus on how patients with nongoblet columnar-lined esophagus ... Full text Link to item Cite

Pancreatic ductal adenocarcinoma with autoimmune pancreatitis-like histologic and immunohistochemical features.

Journal Article Hum Pathol · March 2014 Autoimmune pancreatitis (AIP) often manifests as a mass lesion causing obstructive jaundice, clinically mimicking pancreatic carcinoma. A diagnosis of AIP may obviate the need for surgical resection, as most patients respond to steroid treatment. However, ... Full text Link to item Cite

Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma

Journal Article Journal of Gastrointestinal Oncology · January 1, 2014 Background: Cervical esophageal carcinoma (CEC) is an uncommon malignancy. Limited data supports the use of definitive chemoradiotherapy (CRT) as primary treatment. Furthermore, the role of human papillomavirus (HPV) tumor infection in CEC remains unknown. ... Full text Cite

A subset of Rosai-Dorfman disease exhibits features of IgG4-related disease.

Journal Article Am J Clin Pathol · May 2013 In this study we investigated the distribution of IgG4+ plasma cells and regulatory T (T(REG)) cells, a major regulator of IgG4 production, in nodal and extranodal Rosai-Dorfman disease (RDD). Twenty-six specimens (15 nodal, 11 extranodal) were examined, w ... Full text Link to item Cite

Immunohistochemistry for immunoglobulin G4 on paraffin sections for the diagnosis of pemphigus.

Journal Article Arch Pathol Lab Med · November 2012 CONTEXT: Pemphigus is a group of autoimmune vesiculobullous diseases characterized by immunoglobulin G (IgG) antibodies directed against desmosomal adhesion proteins, with IgG4 being the predominant subclass in active diseases. Direct immunofluorescence fo ... Full text Link to item Cite

Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level.

Journal Article FASEB J · October 2009 Vascular endothelial growth factor (VEGF) is a well-established stimulator of vascular permeability and angiogenesis, whereas thrombospondin-1 (TSP-1) is a potent angiogenic inhibitor. In this study, we have found that the TSP-1 receptors CD36 and beta1 in ... Full text Link to item Cite

A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR.

Journal Article Cancer Res · May 1, 2009 As tumor development relies on a coordination of angiogenesis and tumor growth, an efficient antitumor strategy should target both the tumor and its associated vessels. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a ... Full text Link to item Cite

Adeno-associated virus-mediated antiangiogenic gene therapy with thrombospondin-1 type 1 repeats and endostatin.

Journal Article Clin Cancer Res · July 1, 2007 PURPOSE: Recombinant adeno-associated virus (rAAV)-mediated antiangiogenic gene therapy offers a powerful strategy for cancer treatment, maintaining sustained levels of antiangiogenic factors with coincident enhanced therapeutic efficacy. We aimed to devel ... Full text Link to item Cite

Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model.

Journal Article Cancer Lett · March 8, 2007 Thrombospondin-1 is one of most important natural angiogenic inhibitors. The three thrombospondin-1 type 1 repeats (3TSR), an anti-angiogenic domain of thrombospondin-1, is a promising novel agent for anti-angiogenic treatment. In the present study, we sho ... Full text Link to item Cite

Thrombospondin-based antiangiogenic therapy.

Journal Article Microvasc Res · 2007 Thrombospondins (TSPs) are a family of extracellular matrix proteins that regulate tissue genesis and remodeling. TSP-1 plays a pivotal role in the regulation of both physiological and pathological angiogenesis. The inhibitory effects of TSP-1 on angiogene ... Full text Link to item Cite

Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model.

Journal Article Clin Cancer Res · August 1, 2005 PURPOSE: In this study, we investigated the antitumor efficacy of thrombospondin-1 three type 1 repeats (3TSR), the antiangiogenic domain of thrombospondin-1, in comparison and in combination with gemcitabine, in an orthotopic pancreatic cancer model. EXPE ... Full text Link to item Cite

Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model.

Journal Article Clin Cancer Res · March 15, 2005 PURPOSE: This study investigates the antiangiogenesis and antitumor efficacy of a recombinant protein composed of the three type 1 repeats (3TSR) of thrombospondin-1 in an orthotopic human pancreatic cancer model and provides useful preclinical data for pa ... Full text Link to item Cite