Skip to main content
Journal cover image

Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas.

Publication ,  Journal Article
Harrison, G; Hemmerich, A; Guy, C; Perkinson, K; Fleming, D; McCall, S; Cardona, D; Zhang, X
Published in: Am J Clin Pathol
December 20, 2017

OBJECTIVES: To characterize the expression of SOX11 and TFE3 proteins in solid-pseudopapillary neoplasms (SPNs) and their histologic mimickers. METHODS: Immunohistochemistry for SOX11, TFE3, and β-catenin was performed on 31 cases of surgically resected SPNs. Neuroendocrine tumors, acinar cell carcinomas, and pancreatoblastomas served as controls. RESULTS: Nuclear immunoreactivity for SOX11 was detected in all SPNs and five of 31 control tumors. Nuclear immunoreactivity for TFE3 was detected in 30 SPNs and three control tumors. Nuclear immunoreactivity for β-catenin was detected in all SPNs and four control tumors. The combination of three markers as immunohistochemical panels resulted in optimal sensitivity and specificity. CONCLUSIONS: Both SOX11 and TFE3 were overexpressed in SPNs and may be involved in the pathogenesis. Clinically, SOX11 and TFE3 can be potentially used as diagnostic markers in distinguishing indeterminate SPNs from their histologic mimickers.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Clin Pathol

DOI

EISSN

1943-7722

Publication Date

December 20, 2017

Volume

149

Issue

1

Start / End Page

67 / 75

Location

England

Related Subject Headings

  • Young Adult
  • Sensitivity and Specificity
  • SOXC Transcription Factors
  • Pathology
  • Pancreatic Neoplasms
  • Pancreas
  • Neuroendocrine Tumors
  • Middle Aged
  • Male
  • Immunohistochemistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Harrison, G., Hemmerich, A., Guy, C., Perkinson, K., Fleming, D., McCall, S., … Zhang, X. (2017). Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas. Am J Clin Pathol, 149(1), 67–75. https://doi.org/10.1093/ajcp/aqx142
Harrison, Grant, Amanda Hemmerich, Cynthia Guy, Kathryn Perkinson, Debra Fleming, Shannon McCall, Diana Cardona, and Xuefeng Zhang. “Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas.Am J Clin Pathol 149, no. 1 (December 20, 2017): 67–75. https://doi.org/10.1093/ajcp/aqx142.
Harrison G, Hemmerich A, Guy C, Perkinson K, Fleming D, McCall S, et al. Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas. Am J Clin Pathol. 2017 Dec 20;149(1):67–75.
Harrison, Grant, et al. “Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas.Am J Clin Pathol, vol. 149, no. 1, Dec. 2017, pp. 67–75. Pubmed, doi:10.1093/ajcp/aqx142.
Harrison G, Hemmerich A, Guy C, Perkinson K, Fleming D, McCall S, Cardona D, Zhang X. Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas. Am J Clin Pathol. 2017 Dec 20;149(1):67–75.
Journal cover image

Published In

Am J Clin Pathol

DOI

EISSN

1943-7722

Publication Date

December 20, 2017

Volume

149

Issue

1

Start / End Page

67 / 75

Location

England

Related Subject Headings

  • Young Adult
  • Sensitivity and Specificity
  • SOXC Transcription Factors
  • Pathology
  • Pancreatic Neoplasms
  • Pancreas
  • Neuroendocrine Tumors
  • Middle Aged
  • Male
  • Immunohistochemistry