Scholars@Duke
Yuxin Lin

Yuxin Lin

Postdoctoral Associate
Chemistry

Selected Publications

Super-Resolving Particle Diffusion Heterogeneity in Porous Hydrogels via High-Speed 3D Active-Feedback Single-Particle Tracking Microscopy.

Journal Article Small (Weinheim an der Bergstrasse, Germany) · October 2025 Nanoparticle diffusion in 3D porous structures is critical to understanding natural and synthetic systems but remains underexplored due to limitations in traditional microscopy methods. Here, 3D Single-Molecule Active-feedback Real-time Tracking (3D-SMART) ... Full text Cite

Hour-Long, Kilohertz Sampling Rate Three-Dimensional Single-Virus Tracking in Live Cells Enabled by StayGold Fluorescent Protein Fusions.

Journal Article The journal of physical chemistry. B · June 2024 A viral infection process covers a large range of spatiotemporal scales. Tracking the viral infection process with fluorescent labels over long durations while maintaining a fast sampling rate requires bright and highly photostable labels. StayGold is a re ... Full text Cite

Hour-long, Kilohertz Sampling Rate 3D Single-virus Tracking in Live Cells Enabled by StayGold Fluorescent Protein Fusions

Journal Article · 2024 ABSTRACT The viral infection process covers a large range of spatiotemporal scales. Tracking the viral infection process with fluorescent labels over long durations while maintaining a fast sampling rate requires bright and highly photostable labe ... Full text Cite

Capturing the start point of the virus-cell interaction with high-speed 3D single-virus tracking.

Journal Article Nature methods · December 2022 The early stages of the virus-cell interaction have long evaded observation by existing microscopy methods due to the rapid diffusion of virions in the extracellular space and the large three-dimensional cellular structures involved. Here we present an act ... Full text Cite

Engineering Lipid Nanoparticles for Enhanced Intracellular Delivery of mRNA through Inhalation.

Journal Article ACS nano · September 2022 Despite lipid nanoparticles' (LNPs) success in the effective and safe delivery of mRNA vaccines, an inhalation-based mRNA therapy for lung diseases remains challenging. LNPs tend to disintegrate due to shear stress during aerosolization, leading to ineffec ... Full text Cite

Capturing the start point of the virus-cell interaction with high-speed 3D single-particle tracking

Journal Article · 2021 The early stages of the virus-cell interaction have long evaded observation by existing microscopy methods due to the rapid diffusion of virions in the extracellular space and the large 3D cellular structures involved. Here we present an active-feedback si ... Full text Cite

Skeletal reorganization divergence of N-sulfonyl ynamides.

Journal Article Nature communications · November 2020 Skeletal reorganization is a type of intriguing processes because of their interesting mechanism, high atom-economy and synthetic versatility. Herein, we describe an unusual, divergent skeletal reorganization of N-sulfonyl ynamides. Upon treatment with lit ... Full text Cite

Indole-N-Carboxylic Acids and Indole-N-Carboxamides in Organic Synthesis.

Journal Article Chemistry, an Asian journal · April 2020 Indoles are ubiquitous structures that are found in natural products and biologically active molecules. The synthesis of indoles and indole-involved synthetic methodologies in organic chemistry have been receiving considerable attention. Indole-N-carboxyli ... Full text Cite