Zahra Kabiri

Journal Article PLoS Genet · December 2020 Signal transduction pathways are intricately fine-tuned to accomplish diverse biological processes. An example is the conserved Ras/mitogen-activated-protein-kinase (MAPK) pathway, which exhibits context-dependent signaling output dynamics and regulation. ... Full text Link to item Cite

Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells.

Journal Article J Clin Invest · August 31, 2018 Intestinal homeostasis depends on a slowly proliferating stem cell compartment in crypt cells, followed by rapid proliferation of committed progenitor cells in the transit amplifying (TA) compartment. The balance between proliferation and differentiation i ... Full text Open Access Link to item Cite

PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo.

Journal Article Proc Natl Acad Sci U S A · April 3, 2018 Wnts and R-spondins (RSPOs) support intestinal homeostasis by regulating crypt cell proliferation and differentiation. Ex vivo, Wnts secreted by Paneth cells in organoids can regulate the proliferation and differentiation of Lgr5-expressing intestinal stem ... Full text Open Access Link to item Cite

Wnt inhibition enhances browning of mouse primary white adipocytes.

Journal Article Adipocyte · 2016 The global epidemic in obesity and metabolic syndrome requires novel approaches to tackle. White adipose tissue, traditionally seen as a passive energy-storage organ, can be induced to take on certain characteristics of brown fat in a process called browni ... Full text Link to item Cite

Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells.

Journal Article Blood · August 27, 2015 Wnt signaling controls early embryonic hematopoiesis and dysregulated β-catenin is implicated in leukemia. However, the role of Wnts and their source in adult hematopoiesis is still unclear, and is clinically important as upstream Wnt inhibitors enter clin ... Full text Link to item Cite

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts.

Journal Article Development · June 2014 Wnt/β-catenin signaling supports intestinal homeostasis by regulating proliferation in the crypt. Multiple Wnts are expressed in Paneth cells as well as other intestinal epithelial and stromal cells. Ex vivo, Wnts secreted by Paneth cells can support intes ... Full text Link to item Cite

Evaluation of ARG protein expression in mature B cell lymphomas compared to non-neoplastic reactive lymph node.

Journal Article Cell Immunol · 2009 The participation of Abl-Related Gene (ARG) is demonstrated in pathogenesis of different human malignancies. However there is no conclusive evidence on ARG expression level in mature B cell lymphomas. In this study we evaluated ARG protein expression in Fo ... Full text Link to item Cite