Current Appointments & Affiliations
Adjunct Assistant Professor in the Department of Medicine
·
2013 - Present
Medicine, Cardiology,
Medicine
Recent Publications
MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes.
Journal Article Circ Res · May 25, 2012 RATIONALE: Repopulation of the injured heart with new, functional cardiomyocytes remains a daunting challenge for cardiac regenerative medicine. An ideal therapeutic approach would involve an effective method at achieving direct conversion of injured areas ... Full text Link to item CiteExogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction.
Journal Article Proc Natl Acad Sci U S A · December 7, 2010 Secreted frizzled related protein 2 (Sfrp2) is known as an inhibitor for the Wnt signaling. In recent studies, Sfrp2 has been reported to inhibit the activity of Xenopus homolog of mammalian Tolloid-like 1 metalloproteinase. Bone morphogenic protein 1 (Bmp ... Full text Link to item CiteGenetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium.
Journal Article Circ Res · June 11, 2010 RATIONALE: Although mesenchymal stem cell (MSC) transplantation has been shown to promote cardiac repair in acute myocardial injury in vivo, its overall restorative capacity appears to be restricted mainly because of poor cell viability and low engraftment ... Full text Link to item CiteRecent Grants
Gene Therapy for Long-Term Myocardial Protection
ResearchKey Faculty · Awarded by National Institutes of Health · 2003 - 2014Genetically Altered Mesenchymal Stem Cell; Paracrine Effect on Neovascularization
ResearchFaculty Member · Awarded by National Institutes of Health · 2003 - 2014Renin Gene Expression in Cardiovascular Regulation: Mechanisms of JG Hyperplasia
ResearchAssistant Research Professor · Awarded by National Institutes of Health · 1985 - 2013View All Grants
Education, Training & Certifications
Peking Union Medical College (China) ·
1997
Ph.D.
Shandong Medical University (China) ·
1988
B.M.