Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Peking Union Medical College (China) 1997
  • B.M., Shandong Medical University (China) 1988
• 

  Duke Appointment History

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2008 - 2013
• Research
• 

  Selected Grants

  • Gene Therapy for Long-Term Myocardial Protection awarded by National Institutes of Health 2003 - 2014
  • Genetically Altered Mesenchymal Stem Cell; Paracrine Effect on Neovascularization awarded by National Institutes of Health 2003 - 2014
  • Renin Gene Expression in Cardiovascular Regulation: Mechanisms of JG Hyperplasia awarded by National Institutes of Health 1985 - 2013
• Publications & Artistic Works
• 

  Selected Publications

  • Journal Articles

    • Jayawardena, TM, Egemnazarov, B, Finch, EA, Zhang, L, Payne, JA, Pandya, K, Zhang, Z, Rosenberg, P, Mirotsou, M, and Dzau, VJ. "MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes." Circulation Research 110, no. 11 (May 2012): 1465-1473.  Full Text
    • He, W, Zhang, L, Ni, A, Zhang, Z, Mirotsou, M, Mao, L, Pratt, RE, and Dzau, VJ. "Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction." Proceedings of the National Academy of Sciences of the United States of America 107, no. 49 (December 2010): 21110-21115.  Full Text
    • Huang, J, Zhang, Z, Guo, J, Ni, A, Deb, A, Zhang, L, Mirotsou, M, Pratt, RE, and Dzau, VJ. "Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium." Circulation Research 106, no. 11 (June 2010): 1753-1762.  Full Text
    • Zhang, Z, and Dzau, VJ. "Angiotensin II type 1 receptor-associated protein is an endogenous inhibitor of angiotensin II type 1 receptor action in cardiac hypertrophy: role in check and balance." Hypertension (Dallas, Tex. : 1979) 55, no. 5 (May 2010): 1086-1087.  Full Text
    • Zhang, Z, Deb, A, Zhang, Z, Pachori, A, He, W, Guo, J, Pratt, R, and Dzau, VJ. "Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a." J Mol Cell Cardiol 46, no. 3 (March 2009): 370-377.  Full Text  Link to Item
    • Gnecchi, M, Zhang, Z, Ni, A, and Dzau, VJ. "Paracrine mechanisms in adult stem cell signaling and therapy." Circulation Research 103, no. 11 (November 2008): 1204-1219. (Review)  Full Text
    • Deb, A, Davis, BH, Guo, J, Ni, A, Huang, J, Zhang, Z, Mu, H, and Dzau, VJ. "SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a." Stem Cells (Dayton, Ohio) 26, no. 1 (January 2008): 35-44.  Full Text
    • Matsushita, K, Zhang, Z, Pratt, RE, and Dzau, VJ. "Molecular mechanism of juxtaglomerular cell hyperplasia: a unifying hypothesis." J Am Soc Hypertens 1, no. 3 (May 2007): 164-168.  Full Text  Link to Item

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