Zhiping Zhang

Journal Article Circ Res · May 25, 2012 RATIONALE: Repopulation of the injured heart with new, functional cardiomyocytes remains a daunting challenge for cardiac regenerative medicine. An ideal therapeutic approach would involve an effective method at achieving direct conversion of injured areas ... Full text Link to item Cite

Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction.

Journal Article Proc Natl Acad Sci U S A · December 7, 2010 Secreted frizzled related protein 2 (Sfrp2) is known as an inhibitor for the Wnt signaling. In recent studies, Sfrp2 has been reported to inhibit the activity of Xenopus homolog of mammalian Tolloid-like 1 metalloproteinase. Bone morphogenic protein 1 (Bmp ... Full text Link to item Cite

Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium.

Journal Article Circ Res · June 11, 2010 RATIONALE: Although mesenchymal stem cell (MSC) transplantation has been shown to promote cardiac repair in acute myocardial injury in vivo, its overall restorative capacity appears to be restricted mainly because of poor cell viability and low engraftment ... Full text Link to item Cite

Angiotensin II type 1 receptor-associated protein is an endogenous inhibitor of angiotensin II type 1 receptor action in cardiac hypertrophy: role in check and balance.

Journal Article Hypertension · May 2010 Full text Link to item Cite

Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a.

Journal Article J Mol Cell Cardiol · March 2009 We have demonstrated that mesenchymal stem cells overexpressing the survival gene Akt can confer paracrine protection to ischemic myocytes both in vivo and in vitro through the release of secreted frizzled related protein 2 (Sfrp2). However, the mechanisms ... Full text Link to item Cite

Paracrine mechanisms in adult stem cell signaling and therapy.

Journal Article Circ Res · November 21, 2008 Animal and preliminary human studies of adult cell therapy following acute myocardial infarction have shown an overall improvement of cardiac function. Myocardial and vascular regeneration have been initially proposed as mechanisms of stem cell action. How ... Full text Link to item Cite

SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a.

Journal Article Stem Cells · January 2008 Wnts comprise a family of 20 lipid-modified glycoproteins in mammals and play critical roles during embryological development and organogenesis of several organ systems, including the heart. They are required for mesoderm formation and have been implicated ... Full text Link to item Cite

Molecular mechanism of juxtaglomerular cell hyperplasia: a unifying hypothesis.

Journal Article J Am Soc Hypertens · 2007 Renin is the first enzymatic step of the renin angiotensin cascade and plays an important role in cardiovascular homeostasis. Renin is mainly expressed in and released from specialized juxtaglomerular (JG) cells in kidney. JG cells develop hyperplasia in r ... Full text Link to item Cite