Zhiqing Huang | Scholars@Duke

Zhiqing Huang
Assistant Professor in Obstetrics and Gynecology

Dr. Huang is an Assistant Professor in the Department of Obstetrics and Gynecology, Division of Reproductive Sciences, at Duke University Medical Center. She obtained her MD at North China Coal Medical University in China and her PhD at the University of Heidelberg in Germany under the mentorship of Dr. Ralph Witzgall. She did her postdoctoral training with Dr. Jiemin Wong at Baylor College of Medicine, studying how histone methylation and chromatin modifications regulate androgen receptor transcription. Dr. Huang’s research is focused primarily on ovarian cancer, specifically, on the mechanisms and gene regulation of ovarian cancer recurrence and the impact of the tumor microenvironment on ovarian cancer recurrence.

Current Research Interests

Dr. Huang’s current research interests include: 1) Impacts of the tumor microenvironment on ovarian cancer metastasis and recurrence; 2) Epigenetic modifications in relation to ovarian cancer development and progression 3) Identification of novel drugs that target ovarian cancer stem cells; 4) Functional impacts of epigenetic modifications, resulting from early life exposures, on disease risk (including cancer) in later life; 5) Development of epigenetic screening tools for diagnostic and prognostic utility; 6) In vivo animal models for the study of chemotherapeutic response, with particular focus on ovarian cancer and the delay or prevention of recurrence.

Current Appointments & Affiliations

Assistant Professor in Obstetrics and Gynecology, Obstetrics and Gynecology, Reproductive Sciences, Obstetrics and Gynecology 2021
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2020

Contact Information

Duke PO Box 90534, Durham, NC 27710
The Chesterfield Building, 701 West Main Street, Durham, NC 27701
zhiqing.huang@duke.edu (919) 684-1396
Zhiqing Huang Biosketch
https://obgyn.duke.edu/research/active-research-programs/murphy-research-program/faculty-and-staff

Background
Education, Training, & Certifications
- M.D., North China Coal Medical College (China) 1985
Duke Appointment History
- Assistant Professor in Obstetrics and Gynecology, Obstetrics and Gynecology, Reproductive Sciences, Obstetrics and Gynecology 2019 - 2020
Academic Positions Outside Duke
- Associate Editor, Frontiers in Oncology. 2021
- Scientific Reviewer, Frontiers in Oncology. 2019 - 2021
Recognition
Awards & Honors
Research
Selected Grants
- Role of Age-Related Changes in the Tumor Microenvironment on Ovarian Cancer Progression awarded by National Institutes of Health 2021 - 2023
- Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes? awarded by National Institutes of Health 2017 - 2022
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis awarded by John Templeton Foundation 2017 - 2021
- Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate cancer awarded by Department of Defense 2014 - 2020
- Triggering human anti-tumor stringent response to target recurrent ovarian cancer awarded by Department of Defense 2017 - 2019
- Immune regulated amino acid pathways in Alzheimer's Disease awarded by National Institutes of Health 2016 - 2018
- Functional Genomic Screens of Tumor Recurrence in Ovarian Cancer awarded by Department of Defense 2014 - 2017
- Obesity and deregulation of imprinted genes in early life awarded by National Institutes of Health 2010 - 2015
- Disparities in cervical cancer precursors and deregulation of imprinted genes awarded by National Institutes of Health 2010 - 2014
- Nutrition, Deregulation of Imprinted Genes and Rapid Weight Gain in Early Life awarded by National Institutes of Health 2009 - 2014
- Characterizing Alcohol's Effects on Repair of Liver Injury awarded by National Institutes of Health 2009 - 2012
- Mentored Oriented Research Career Development Award awarded by National Institutes of Health 2000 - 2005
- missing activity
Fellowships, Supported Research, & Other Grants
- The Function of Periostin (POSTN) in the Development of Chemo-Resistance and Recurrence of Ovarian Cancer awarded by Charles B. Hammond Research Fund 2018 - 2020
- Identification of genes associated with ovarian cancer recurrence using FFPE specimens. awarded by Oncology Research Grant by EA|Quintiles and Illumina 2014
- German Research Foundation Scholarship awarded by Heidelberg University, Germany 1996
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Fuemmeler, Bernard F., Mikhail G. Dozmorov, Elizabeth K. Do, Junfeng Jim Zhang, Carole Grenier, Zhiqing Huang, Rachel L. Maguire, Scott H. Kollins, Cathrine Hoyo, and Susan K. Murphy. “DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study.” Environ Health Perspect 129, no. 5 (May 2021): 57010. https://doi.org/10.1289/EHP8099.
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  - Keyhan, Sanaz, Emily Burke, Rose Schrott, Zhiqing Huang, Carole Grenier, Thomas Price, Doug Raburn, et al. “Male obesity impacts DNA methylation reprogramming in sperm.” Clin Epigenetics 13, no. 1 (January 25, 2021): 17. https://doi.org/10.1186/s13148-020-00997-0.
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  - Huang, Zhiqing, Eiji Kondoh, Zachary R. Visco, Tsukasa Baba, Noriomi Matsumura, Emma Dolan, Regina S. Whitaker, et al. “Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance.” Molecular Cancer Therapeutics 20, no. 1 (January 2021): 85–95. https://doi.org/10.1158/1535-7163.mct-20-0119.
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  - Visco, Zachary R., Gregory Sfakianos, Carole Grenier, Marie-Helene Boudreau, Sabrina Simpson, Isabel Rodriguez, Regina Whitaker, et al. “Epigenetic Regulation of Claudin-1 in the Development of Ovarian Cancer Recurrence and Drug Resistance.” Front Oncol 11 (2021): 620873. https://doi.org/10.3389/fonc.2021.620873.
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  - Batinic-Haberle, Ines, Artak Tovmasyan, Zhiqing Huang, Weina Duan, Li Du, Sharareh Siamakpour-Reihani, Zhipeng Cao, Huaxin Sheng, Ivan Spasojevic, and Angeles Alvarez Secord. “H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways.” Oxid Med Cell Longev 2021 (2021): 6653790. https://doi.org/10.1155/2021/6653790.
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  - Acharya, K. S., R. Schrott, C. Grenier, Z. Huang, Z. Holloway, A. Hawkey, E. D. Levin, and S. K. Murphy. “Epigenetic alterations in cytochrome P450 oxidoreductase (Por) in sperm of rats exposed to tetrahydrocannabinol (THC).” Scientific Reports 10, no. 1 (December 1, 2020). https://doi.org/10.1038/s41598-020-69204-7.
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  - Schrott, Rose, Maya Rajavel, Kelly Acharya, Zhiqing Huang, Chaitanya Acharya, Andrew Hawkey, Erica Pippen, H Kim Lyerly, Edward D. Levin, and Susan K. Murphy. “Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin.” Sci Rep 10, no. 1 (September 29, 2020): 16022. https://doi.org/10.1038/s41598-020-72783-0.
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  - Yang, Wen-Hsuan, Zhiqing Huang, Jianli Wu, Chien-Kuang C. Ding, Susan K. Murphy, and Jen-Tsan Chi. “A TAZ-ANGPTL4-NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer.” Mol Cancer Res 18, no. 1 (January 2020): 79–90. https://doi.org/10.1158/1541-7786.MCR-19-0691.
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  - House, John S., Jonathan Hall, Sarah S. Park, Antonio Planchart, Eric Money, Rachel L. Maguire, Zhiqing Huang, et al. “Cadmium exposure and MEG3 methylation differences between Whites and African Americans in the NEST Cohort.” Environ Epigenet 5, no. 3 (July 2019): dvz014. https://doi.org/10.1093/eep/dvz014.
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  - Meekins, A Rebecca, Susan K. Murphy, Carole Grenier, Zhiqing Huang, Megan S. Bradley, Cindy L. Amundsen, Jennifer Wu, and Nazema Y. Siddiqui. “Role of β-3 adrenergic receptor polymorphism in overactive bladder.” Neurourol Urodyn 38, no. 5 (June 2019): 1261–65. https://doi.org/10.1002/nau.24006.
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  - Do, E. K., N. L. Zucker, Z. Y. Huang, J. C. Schechter, S. H. Kollins, R. L. Maguire, S. K. Murphy, C. Hoyo, and B. F. Fuemmeler. “Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children.” Pediatr Obes 14, no. 2 (February 2019): e12454. https://doi.org/10.1111/ijpo.12454.
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  - Kantor, Boris, Lidia Tagliafierro, Jeffrey Gu, Madison E. Zamora, Ekaterina Ilich, Carole Grenier, Zhiqing Y. Huang, Susan Murphy, and Ornit Chiba-Falek. “Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.” Mol Ther 26, no. 11 (November 7, 2018): 2638–49. https://doi.org/10.1016/j.ymthe.2018.08.019.
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  - Gomih, Ayodele, Jennifer S. Smith, Kari E. North, Michael G. Hudgens, Wendy R. Brewster, Zhiqing Huang, David Skaar, et al. “DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions.” Int J Cancer 143, no. 3 (August 1, 2018): 552–60. https://doi.org/10.1002/ijc.31350.
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  - Tindula, Gwen, Susan K. Murphy, Carole Grenier, Zhiqing Huang, Karen Huen, Maria Escudero-Fung, Asa Bradman, Brenda Eskenazi, Cathrine Hoyo, and Nina Holland. “DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure.” Epigenomics 10, no. 7 (July 2018): 1011–26. https://doi.org/10.2217/epi-2017-0178.
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  - House, John S., Michelle Mendez, Rachel L. Maguire, Sarah Gonzalez-Nahm, Zhiqing Huang, Julie Daniels, Susan K. Murphy, Bernard F. Fuemmeler, Fred A. Wright, and Cathrine Hoyo. “Periconceptional Maternal Mediterranean Diet Is Associated With Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted Genes.” Front Cell Dev Biol 6 (2018): 107. https://doi.org/10.3389/fcell.2018.00107.
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  - Murphy, Susan K., Nilda Itchon-Ramos, Zachary Visco, Zhiqing Huang, Carole Grenier, Rose Schrott, Kelly Acharya, et al. “Cannabinoid exposure and altered DNA methylation in rat and human sperm.” Epigenetics 13, no. 12 (2018): 1208–21. https://doi.org/10.1080/15592294.2018.1554521.
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  - Cordero, Francisco J., Zhiqing Huang, Carole Grenier, Xingyao He, Guo Hu, Roger E. McLendon, Susan K. Murphy, Rintaro Hashizume, and Oren J. Becher. “Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG.” Mol Cancer Res 15, no. 9 (September 2017): 1243–54. https://doi.org/10.1158/1541-7786.MCR-16-0389.
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  - Liu, Yongmei, Lindsay M. Reynolds, Jingzhong Ding, Li Hou, Kurt Lohman, Tracey Young, Wei Cui, et al. “Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis.” Nat Commun 8, no. 1 (August 30, 2017): 393. https://doi.org/10.1038/s41467-017-00517-4.
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  - McCullough, Lauren E., Erline E. Miller, Laura E. Calderwood, Nitin Shivappa, Susan E. Steck, Michele R. Forman, Michelle A Mendez, et al. “Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?” Epigenetics 12, no. 8 (August 2017): 688–97. https://doi.org/10.1080/15592294.2017.1347241.
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  - Dewi, Fitriya N., Charles E. Wood, Cynthia J. Willson, Thomas C. Register, Cynthia J. Lees, Timothy D. Howard, Zhiqing Huang, et al. “Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques.” Cancer Prev Res (Phila) 9, no. 5 (May 2016): 385–95. https://doi.org/10.1158/1940-6207.CAPR-15-0165.
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  - Fuemmeler, Bernard F., Chien-Ti Lee, Adelheid Soubry, Edwin S. Iversen, Zhiqing Huang, Amy P. Murtha, Joellen M. Schildkraut, Randy L. Jirtle, Susan K. Murphy, and Cathrine Hoyo. “DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament.” Genet Epigenet 8 (2016): 59–67. https://doi.org/10.4137/GEG.S40538.
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  - Soubry, Adelheid, Lisa Guo, Zhiqing Huang, Cathrine Hoyo, Stephanie Romanus, Thomas Price, and Susan K. Murphy. “Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study.” Clin Epigenetics 8 (2016): 51. https://doi.org/10.1186/s13148-016-0217-2.
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  - Su, Dan, Xuting Wang, Michelle R. Campbell, Devin K. Porter, Gary S. Pittman, Brian D. Bennett, Ma Wan, et al. “Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.” Plos One 11, no. 12 (2016): e0166486. https://doi.org/10.1371/journal.pone.0166486.
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  - Nye, Monica D., Katherine E. King, Thomas H. Darrah, Rachel Maguire, Dereje D. Jima, Zhiqing Huang, Michelle A. Mendez, et al. “Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort.” Environmental Epigenetics 2, no. 1 (January 2016). https://doi.org/10.1093/eep/dvv009.
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  - Sachdeva, Mohit, Rebecca D. Dodd, Zhiqing Huang, Carole Grenier, Yan Ma, Dina C. Lev, Diana M. Cardona, Susan K. Murphy, and David G. Kirsch. “Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.” Cancer Lett 369, no. 1 (December 1, 2015): 202–11. https://doi.org/10.1016/j.canlet.2015.08.016.
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  - Varadaraj, Archana, Pratik Patel, Anne Serrao, Tirthankar Bandyopadhay, Nam Y. Lee, Amir A. Jazaeri, Zhiqing Huang, Susan K. Murphy, and Karthikeyan Mythreye. “Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.” Neoplasia 17, no. 11 (November 2015): 826–38. https://doi.org/10.1016/j.neo.2015.11.003.
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  - Ding, Jingzhong, Lindsay M. Reynolds, Tanja Zeller, Christian Müller, Kurt Lohman, Barbara J. Nicklas, Stephen B. Kritchevsky, et al. “Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease.” Diabetes 64, no. 10 (October 2015): 3464–74. https://doi.org/10.2337/db14-1314.
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  - Keenan, Melissa M., Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D. Stevens, Olga Ilkayeva, et al. “ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.” Plos Genet 11, no. 10 (October 2015): e1005599. https://doi.org/10.1371/journal.pgen.1005599.
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  - Murphy, Susan K., Erin Erginer, Zhiqing Huang, Zachary Visco, and Cathrine Hoyo. “Genotype-Epigenotype Interaction at the IGF2 DMR.” Genes (Basel) 6, no. 3 (August 28, 2015): 777–89. https://doi.org/10.3390/genes6030777.
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  - Vidal, Adriana C., Viktoriya Semenova, Thomas Darrah, Avner Vengosh, Zhiqing Huang, Katherine King, Monica D. Nye, et al. “Maternal cadmium, iron and zinc levels, DNA methylation and birth weight.” Bmc Pharmacol Toxicol 16 (July 15, 2015): 20. https://doi.org/10.1186/s40360-015-0020-2.
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  - Soubry, A., S. K. Murphy, F. Wang, Z. Huang, A. C. Vidal, B. F. Fuemmeler, J. Kurtzberg, et al. “Newborns of obese parents have altered DNA methylation patterns at imprinted genes.” Int J Obes (Lond) 39, no. 4 (April 2015): 650–57. https://doi.org/10.1038/ijo.2013.193.
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  - Mo, Lihong, Vendula Pospichalova, Zhiqing Huang, Susan K. Murphy, Sturgis Payne, Fang Wang, Margaret Kennedy, et al. “Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells.” Plos One 10, no. 7 (2015): e0131579. https://doi.org/10.1371/journal.pone.0131579.
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  - Soubry, A., S. K. Murphy, F. Wang, Z. Huang, A. C. Vidal, B. F. Fuemmeler, J. Kurtzberg, et al. “Newborns of obese parents have altered DNA methylation patterns at imprinted genes.” International Journal of Obesity 39, no. 4 (January 1, 2015): 650–57. https://doi.org/10.1038/ijo.2013.193.
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  - Hoyo, Cathrine, Anne Kjersti Daltveit, Edwin Iversen, Sara E. Benjamin-Neelon, Bernard Fuemmeler, Joellen Schildkraut, Amy P. Murtha, et al. “Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort.” Epigenetics 9, no. 8 (August 2014): 1120–30. https://doi.org/10.4161/epi.29332.
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  - Yamaguchi, Ken, Zhiqing Huang, Noriomi Matsumura, Masaki Mandai, Takako Okamoto, Tsukasa Baba, Ikuo Konishi, Andrew Berchuck, and Susan K. Murphy. “Epigenetic determinants of ovarian clear cell carcinoma biology.” Int J Cancer 135, no. 3 (August 1, 2014): 585–97. https://doi.org/10.1002/ijc.28701.
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  - Vidal, A. C., N. M. Henry, S. K. Murphy, O. Oneko, M. Nye, J. A. Bartlett, F. Overcash, et al. “PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer.” Clinical and Translational Oncology 16, no. 3 (March 1, 2014): 266–72. https://doi.org/10.1007/s12094-013-1067-4.
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  - Vidal, Adriana C., Sara E. Benjamin Neelon, Ying Liu, Abbas M. Tuli, Bernard F. Fuemmeler, Cathrine Hoyo, Amy P. Murtha, et al. “Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans.” Genet Epigenet 6 (2014): 37–44. https://doi.org/10.4137/GEG.S18067.
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  - Vidal, A. C., S. K. Murphy, A. P. Murtha, J. M. Schildkraut, A. Soubry, Z. Huang, S. E. B. Neelon, et al. “Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring.” Int J Obes (Lond) 37, no. 7 (July 2013): 907–13. https://doi.org/10.1038/ijo.2013.47.
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  - Liu, Ying, Cathrine Hoyo, Susan Murphy, Zhiqing Huang, Francine Overcash, Jennifer Thompson, Haywood Brown, and Amy P. Murtha. “DNA methylation at imprint regulatory regions in preterm birth and infection.” Am J Obstet Gynecol 208, no. 5 (May 2013): 395.e1-395.e7. https://doi.org/10.1016/j.ajog.2013.02.006.
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  - Soubry, Adelheid, Joellen M. Schildkraut, Amy Murtha, Frances Wang, Zhiqing Huang, Autumn Bernal, Joanne Kurtzberg, Randy L. Jirtle, Susan K. Murphy, and Cathrine Hoyo. “Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort.” Bmc Med 11 (February 6, 2013): 29. https://doi.org/10.1186/1741-7015-11-29.
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  - Alvarez Secord, Angeles, Marcus Q. Bernardini, Gloria Broadwater, Lisa A. Grace, Zhiqing Huang, Tsukasa Baba, Eiji Kondoh, Gregory Sfakianos, Laura J. Havrilesky, and Susan K. Murphy. “TP53 Status is Associated with Thrombospondin1 Expression In vitro.” Front Oncol 3 (2013): 269. https://doi.org/10.3389/fonc.2013.00269.
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  - Bassil, Christopher F., Zhiqing Huang, and Susan K. Murphy. “Bisulfite pyrosequencing.” Methods Mol Biol 1049 (2013): 95–107. https://doi.org/10.1007/978-1-62703-547-7_9.
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  - Huang, Zhiqing, Christopher F. Bassil, and Susan K. Murphy. “Bisulfite sequencing of cloned alleles.” Methods Mol Biol 1049 (2013): 83–94. https://doi.org/10.1007/978-1-62703-547-7_8.
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  - Huang, Zhiqing, Christopher F. Bassil, and Susan K. Murphy. “Methylation-specific PCR.” Methods Mol Biol 1049 (2013): 75–82. https://doi.org/10.1007/978-1-62703-547-7_7.
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  - Huang, Zhiqing, and Susan K. Murphy. “Increased Intragenic IGF2 Methylation is Associated with Repression of Insulator Activity and Elevated Expression in Serous Ovarian Carcinoma.” Front Oncol 3 (2013): 131. https://doi.org/10.3389/fonc.2013.00131.
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  - Murphy, Susan K., Christopher F. Bassil, and Zhiqing Huang. “Main principles and outcomes of DNA methylation analysis.” Methods Mol Biol 1049 (2013): 67–74. https://doi.org/10.1007/978-1-62703-547-7_6.
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  - Nye, Monica D., Cathrine Hoyo, Zhiqing Huang, Adriana C. Vidal, Frances Wang, Francine Overcash, Jennifer S. Smith, et al. “Associations between methylation of paternally expressed gene 3 (PEG3), cervical intraepithelial neoplasia and invasive cervical cancer.” Plos One 8, no. 2 (2013): e56325. https://doi.org/10.1371/journal.pone.0056325.
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  - Joubert, Bonnie R., Siri E. Håberg, Roy M. Nilsen, Xuting Wang, Stein E. Vollset, Susan K. Murphy, Zhiqing Huang, et al. “450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy.” Environ Health Perspect 120, no. 10 (October 2012): 1425–31. https://doi.org/10.1289/ehp.1205412.
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  - Liu, Ying, Susan K. Murphy, Amy P. Murtha, Bernard F. Fuemmeler, Joellen Schildkraut, Zhiqing Huang, Francine Overcash, et al. “Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements.” Epigenetics 7, no. 7 (July 2012): 735–46. https://doi.org/10.4161/epi.20734.
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  - Perkins, Ellen, Susan K. Murphy, Amy P. Murtha, Joellen Schildkraut, Randy L. Jirtle, Wendy Demark-Wahnefried, Michele R. Forman, et al. “Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children.” J Pediatr 161, no. 1 (July 2012): 31–39. https://doi.org/10.1016/j.jpeds.2012.01.015.
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  - Huang, Zhiqing, William J. Lowery, Andrew Berchuck, and Susan K. Murphy. “Abstract 5363: Aggregation rather than monoclonal expansion explains ovarian cancer spheroid formation.” Tumor Biology, April 15, 2012. https://doi.org/10.1158/1538-7445.am2012-5363.
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  - Hoyo, Cathrine, Kimberly Fortner, Amy P. Murtha, Joellen M. Schildkraut, Adelheid Soubry, Wendy Demark-Wahnefried, Randy L. Jirtle, et al. “Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight.” Cancer Causes Control 23, no. 4 (April 2012): 635–45. https://doi.org/10.1007/s10552-012-9932-y.
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  - Murphy, Susan K., Abayomi Adigun, Zhiqing Huang, Francine Overcash, Frances Wang, Randy L. Jirtle, Joellen M. Schildkraut, Amy P. Murtha, Edwin S. Iversen, and Cathrine Hoyo. “Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke.” Gene 494, no. 1 (February 15, 2012): 36–43. https://doi.org/10.1016/j.gene.2011.11.062.
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  - Murphy, Susan K., Zhiqing Huang, and Cathrine Hoyo. “Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues.” Plos One 7, no. 7 (2012): e40924. https://doi.org/10.1371/journal.pone.0040924.
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  - Yamamura, Shogo, Noriomi Matsumura, Masaki Mandai, Zhiqing Huang, Tomonori Oura, Tsukasa Baba, Junzo Hamanishi, et al. “The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer.” Int J Cancer 130, no. 1 (January 1, 2012): 20–28. https://doi.org/10.1002/ijc.25961.
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  - Bondurant, Amy E., Zhiqing Huang, Regina S. Whitaker, Lauren R. Simel, Andrew Berchuck, and Susan K. Murphy. “Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer.” Gynecol Oncol 123, no. 3 (December 2011): 581–87. https://doi.org/10.1016/j.ygyno.2011.08.029.
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  - Alvarez Secord, Angeles, Kathleen M. Darcy, Alan Hutson, Zhiqing Huang, Paula S. Lee, Elizabeth L. Jewell, Laura J. Havrilesky, Maurie Markman, Franco Muggia, and Susan K. Murphy. “The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study.” Gynecol Oncol 123, no. 2 (November 2011): 314–19. https://doi.org/10.1016/j.ygyno.2011.08.003.
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  - Soubry, A., Sk Murphy, Z. Huang, A. Murtha, Jm Schildkraut, Rl Jirtle, F. Wang, et al. “The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring.” Clin Epigenetics 3 (October 26, 2011): 2. https://doi.org/10.1186/1868-7083-3-2.
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  - Hoyo, Cathrine, Amy P. Murtha, Joellen M. Schildkraut, Randy L. Jirtle, Wendy Demark-Wahnefried, Michele R. Forman, Edwin S. Iversen, et al. “Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy.” Epigenetics 6, no. 7 (July 2011): 928–36. https://doi.org/10.4161/epi.6.7.16263.
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  - Matsumura, Noriomi, Zhiqing Huang, Seiichi Mori, Tsukasa Baba, Shingo Fujii, Ikuo Konishi, Edwin S. Iversen, Andrew Berchuck, and Susan K. Murphy. “Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer.” Genome Res 21, no. 1 (January 2011): 74–82. https://doi.org/10.1101/gr.108803.110.
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  - Lee, Paula S., Vanessa S. Teaberry, Amy E. Bland, Zhiqing Huang, Regina S. Whitaker, Tsukasa Baba, Shingo Fujii, Angeles Alvarez Secord, Andrew Berchuck, and Susan K. Murphy. “Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer.” Int J Cancer 126, no. 6 (March 15, 2010): 1378–89. https://doi.org/10.1002/ijc.24797.
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  - Ding, X., A. B. Mohd, Z. Huang, T. Baba, M. Q. Bernardini, H. K. Lyerly, A. Berchuck, S. K. Murphy, A. B. Buermeyer, and G. R. Devi. “MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition.” Br J Cancer 101, no. 2 (July 21, 2009): 269–77. https://doi.org/10.1038/sj.bjc.6605180.
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  - Matsumura, Noriomi, Zhiqing Huang, Tsukasa Baba, Paula S. Lee, Jason C. Barnett, Seiichi Mori, Jeffrey T. Chang, et al. “Yin yang 1 modulates taxane response in epithelial ovarian cancer.” Mol Cancer Res 7, no. 2 (February 2009): 210–20. https://doi.org/10.1158/1541-7786.MCR-08-0255.
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  - Baba, T., P. A. Convery, N. Matsumura, R. S. Whitaker, E. Kondoh, T. Perry, Z. Huang, et al. “Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.” Oncogene 28, no. 2 (January 15, 2009): 209–18. https://doi.org/10.1038/onc.2008.374.
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  - Schildkraut, Joellen M., Susan K. Murphy, Rachel T. Palmieri, Edwin Iversen, Patricia G. Moorman, Zhiqing Huang, Susan Halabi, et al. “Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.” Cancer Epidemiol Biomarkers Prev 16, no. 3 (March 2007): 473–80. https://doi.org/10.1158/1055-9965.EPI-06-0868.
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  - Murphy, Susan K., Zhiqing Huang, Yaqing Wen, Monique A. Spillman, Regina S. Whitaker, Lauren R. Simel, Teresa D. Nichols, Jeffrey R. Marks, and Andrew Berchuck. “Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer.” Mol Cancer Res 4, no. 4 (April 2006): 283–92. https://doi.org/10.1158/1541-7786.MCR-05-0138.
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  - Murphy, Susan K., Catherine M. Nolan, Zhiqing Huang, Katerina S. Kucera, Brad A. Freking, Timothy P. L. Smith, Kreg A. Leymaster, Jennifer R. Weidman, and Randy L. Jirtle. “Callipyge mutation affects gene expression in cis: a potential role for chromatin structure.” Genome Res 16, no. 3 (March 2006): 340–46. https://doi.org/10.1101/gr.4389306.
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  - Huang, Zhiqing, Yaqing Wen, Ruby Shandilya, Jeffrey R. Marks, Andrew Berchuck, and Susan K. Murphy. “High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer.” Nucleic Acids Res 34, no. 2 (2006): 555–63. https://doi.org/10.1093/nar/gkj468.
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  - Gollob, Jared A., Catherine J. Sciambi, Zhiqing Huang, and Holly K. Dressman. “Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma.” Cancer Res 65, no. 19 (October 1, 2005): 8869–77. https://doi.org/10.1158/0008-5472.CAN-05-1387.
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  - Bradley, Megan S., Marie-Helene Boudreau, Carole Grenier, Zhiqing Huang, Susan K. Murphy, and Nazema Y. Siddiqui. “Urine RNA Processing in a Clinical Setting: Comparison of 3 Protocols.” Female Pelvic Med Reconstr Surg 25, no. 3 (n.d.): 247–51. https://doi.org/10.1097/SPV.0000000000000525.
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- Book Sections
  - Huang, Zhiqing. “Bisulfite sequencing of cloned alleles.” In Basic Methods in Molecular Biology. Elsevier, 2012.
  - Huang, Zhiqing. “Bisulfite pyrosequencing.” In Basic Methods in Molecular Biology. Elsevier, 2012.
  - Huang, Zhiqing. “Methylation-specific PCR.” In Basic Methods in Molecular Biology. Elsevier, 2012.
  - Huang, Zhiqing. “Main principles and outcomes of DNA methylation analysis.” In Methods in Molecular Biology: Protocols in Human Molecular Genetics, 1991.
    Link to Item
- Conference Papers
  - Huang, Zhiqing, Brad Foster, Carole Grenier, Gregory Sfakianos, Regina Whitaker, Andrew Berchuck, and Susan K. Murphy. “Abstract 1991: Enhanced role of the extracellular matrix in ovarian cancer recurrence.” In Tumor Biology. American Association for Cancer Research, 2017. https://doi.org/10.1158/1538-7445.am2017-1991.
    Full Text
  - Huang, Zhiqing, Zachery Visco, Gregory Sfakianos, Regina Whitaker, Andrew Berchuck, and Susan Murphy. “Abstract POSTER-BIOL-1319: Temporal shifts in the epigenetic regulation of tight junctions from primary to recurrent ovarian cancer.” In Biology of Ovarian Cancer. American Association for Cancer Research, 2015. https://doi.org/10.1158/1557-3265.ovcasymp14-poster-biol-1319.
    Full Text
  - Huang, Zhiqing, Zachery Visco, Gregory Sfakianos, Regina Whitaker, Andrew Berchuck, and Susan K. Murphy. “Abstract 2236: Emergence of epigenetic regulation of tight junction genes in recurrent serous epithelial ovarian cancer.” In Tumor Biology. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-2236.
    Full Text
  - Nye, Monica D., Adriana Vidal, Cathrine Hoyo, and Susan K. Murphy. “Abstract 5354: Altered DNA methylation at imprinted insulin-like growth factor-2 (IGF2) resulting from heavy metal exposurein vitroandin vivoin infants from the newborn epigenetic study (NEST).” In Molecular and Cellular Biology. American Association for Cancer Research, 2013. https://doi.org/10.1158/1538-7445.am2013-5354.
    Full Text
  - Nye, Monica D., Adriana C. Vidal, Marilie D. Gammon, and Cathrine Hoyo. “Abstract B35: Altered DNA methylation at imprinted insulin-like growth factor-2 (IGF2) resulting from heavy metal exposure in vitro and in vivo in infants from the Newborn Epigenetic STudy (NEST).” In Cell, Molecular, and Tumor Biology. American Association for Cancer Research, 2012. https://doi.org/10.1158/1055-9965.disp12-b35.
    Full Text
  - Murphy, S., F. Overcash, Z. Huang, B. Vasquez, B. Hernandez, J. Obure, P. Mlay, O. Olola, J. Bartlett, and C. Hoyo. “Progressive epigenetic deregulation of insulin-like growth factor 2 in cervical cancer precursors in HIV plus and HIV- patients.” In Gynecologic Oncology, 116:S38–S38. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010.
    Link to Item
  - Huang, Zhiqing, Alison H. Gusberg, Regina S. Whitaker, Andrew Berchuck, and Susan K. Murphy. “YY1 imprint status and role in ovarian carcinogenesis.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.
    Link to Item
  - Huang, Zhiqing. “Nuclear distribution of the adapter protein KRIP-1/TIF-1/KAP-1 and the KRAB-zinc finger protein KID-1,” n.d.
  - Huang, Zhiqing. “The complexity of transcription regulation by androgen receptor in chromatin,” n.d.
  - Huang, Zhiqing. “The complexity of transcriptional regulation by androgen receptor in chromatin,” n.d.
  - Huang, Zhiqing. “Treatment of melanoma with a combination of type I and type II interferons results in growth ingibition and the induction of apoptosis associated with the loss of microphthalmia transcription factor (Mitf) expression,” n.d.
  - Huang, Zhiqing. “High throughput detection of M6P/IGF2R loss of heterozygosity,” n.d.
  - Huang, Zhiqing. “DNA Methylation in Ovarian Cancer is Related to Poor Prognosis and Suppression of the TGF-beta Signaling Pathway,” n.d.
- Datasets
  - Murphy, Susan, Regina Whitaker, Gregory Sfakianos, Andrew Berchuck, and Zhiqing Huang. “Gene Expression using Affymetrix Human Genome U133 Plus 2 Arrays from 16 Primary and Recurrent Serous Epithelial Ovarian Cancers,” January 15, 2021. https://doi.org/10.7924/r43f4sx2k.
    Data Access
  - Murphy, Susan, Gregory Sfakianos, Regina Whitaker, Andrew Berchuk, and Zhiqing Huang. “Primary and recurrent (second-look surgery) serous epithelial ovarian cancers Illumina Infinium HumanMethylation450 BeadChip data,” January 8, 2021. https://doi.org/10.7924/r4765hq57.
    Data Access
  - Schrott, Rose, Douglas Raburn, Scott Kollins, Edward Levin, David Corcoran, Marie-Helene Boudreau, Zhiqing Huang, et al. “Data from: Cannabinoid exposure and altered DNA methylation in rat and human sperm,” August 25, 2020. https://doi.org/10.7924/r4v122j79.
    Data Access
Teaching & Mentoring
Recent Courses
- BIOLOGY 293: Research Independent Study 2021
Advising & Mentoring
- Gynecologic Oncology Fellows
  
  Paula Lee, MD, Gyn-Onc Fellow, Duke University, 2004-2007
  Current position: Assistant Professor, Duke University
  
  Amy E. BonDurant, MD, Gyn-Onc Fellow, Duke University, 2005-2008
  Current position: Pacific Gynecology Specialists, Seattle, WA
  
  Marcus Bernardini, MD, Visiting Fellow, University of Toronto, 2006-2007
  Current position: Assistant Professor, University of Toronto
  
  Jason Cory Barnett, MD, Gyn-Onc Fellow, Duke University, 2007-2008
  Current position: Department of OB/GYN, Fort Sam Houston Texas
  
  Gregory Sfakianos, MD, Gyn-Onc Fellow, Duke University, 2009-2010
  Current position: St. Francis Gynecologic Oncology, Columbus, GA
  
  William J. Lowery, MD, Gyn-Onc Fellow, Duke University, 2010-2011
  Current position: Gynecologic Oncologist, US Army, Rockville, MD
  
  Brittany Davidson, MD, Gyn-Onc Fellow, Duke University, 2013-2014
  Current position: Assistant Professor, Duke University
  
  Reproductive Endocrinology Fellows
  
  Sanaz Keyhan, MD, Duke University, 2015-2016
  Current position: Palo Alto Medical Foundation, San Jose, California
  
  Kelly Acharya, MD, Duke University, 2017-2018
  Current position: Assistant Professor of OBGYN, Reproductive Endocrinology and Infertility, Duke University
  
  Stephanie Smeltzer, MD, Duke University, 2018-2019
  Future position: Atlanta Center for Reproductive Medicine
  
  Postdoctoral Fellows
  
  Lihong Zhu, MD, 2011-2012
  Current position: Assistant Professor, Peking University, Beijing
  
  Graduate Students
  Rotations
  
  Yihan Liao, Cellular and Molecular Biology 2016
  Emily Liang, Integrated Toxicology and Environmental Health Program 2017
  Laura Childers, Integrated Toxicology and Environmental Health Program 2018
  
  Thesis
  Valerie Rojas, Pharmacology Scientist Training Program (Master’s) 2013-2015
  Current position: Regulatory Consultant, Syneos Health Commercial Solutions
  
  Rashmi Joglekar, PhD Candidate, Integrated Toxicology and Environmental Health Program 2015-2019
  Current position: Earthjustice, Scientist, Toxic Exposure and Health Program, Washington, DC
  
  Rose Schrott, Integrated Toxicology and Environmental Health Program 2017 -
  PhD Candidate
  
  Emma Dolan, Pharmacology and Cancer Biology 2018 -
  PhD Candidate
  
  Christine Crute, Integrated Toxicology and Environmental Health Program 2018 -
  PhD Candidate
  
  Dillon King, Integrated Toxicology and Environmental Health Program 2019 -
  
  Medical Students – Third Year Research
  
  Patricia Convery, 2006-2007
  Current position: Private Practice, Raleigh. North Carolina
  
  Kerone Walker, 2008-2009
  Current Position: Obstetrics and Gynecology, UCLA Medical Center
  
  Jaemin Park, (Duke-NUS), 2011-2013 (two years of research)
  Current position: Investment Professional at Partner’s Group
  
  Isabel Rodriguez, 2014-2015
  Current position: Gynecologic Oncology Fellowship, University of Washington, Seattle
  
  Barbara Blachut, (Washington University, St. Louis), summer, 2017
  
  Cassie Hobbs, 2017-2018
  
  Undergraduate Students
  
  Yaqing Wen, Duke University, 2004-2006
  Bouncer Program, Independent Study Student
  Current position: Board Certified Internist, Charlottesville, Virginia
  
  Jacob Berchuck, Duke University, 2004
  Current position: Medical Oncologist, Dana Farber Cancer Institute
  
  Lisa Chen, Duke University, 2005-2007
  Independent Study Student, Honors Thesis Student
  Current position: Clinical Instructor, Ophthalmology, Stanford University
  
  Natasha Duggan, University of California, San Francisco, 2006-2009
  Current position: Postdoctoral Trainee, University of Miami
  
  Nancy Anoruo, University of Florida, Gainesville, 2006
  Institute for Genome Sciences and Policy Summer Research Program
  Current position: Adjunct Instructor in Biology, American University
  
  Cara Davis, University of North Carolina, Asheville, 2008
  Current position: Project Specialist, INC Research, Raleigh, North Carolina
  
  Jack Fitzgibbons, Duke University, 2010
  Independent Study Student
  Current position: Director of Strategic Initiatives, SMS Assist, Chicago, Illinois
  
  Masashi Ono, University of North Carolina, Asheville, 2010
  
  Christopher Bassil, Duke University, 2011-2012
  Current position: Medical Scientist Training Program, Duke University
  
  Shamaita Majumdar, Duke University, 2011-2014
  Independent Study Student, Honors Thesis Student
  Current position: Medical Student, Washington University St. Louis, Missouri
  
  Clara Lee, Duke University, 2012-2014
  Independent Study Student, Honors Thesis Student
  Current position: Medical Student, Emory University, Atlanta, Georgia
  
  Jason Chin, Duke University, 2012-2014
  Independent Study Student
  
  Sonya Jooma, Duke University, 2013-2014
  Independent Study Student
  Current Position: Health Policy Analyst, NHGRI
  
  Lisa Guo, Duke University, 2013-2014
  Independent Study Student, Honors Thesis Student
  
  Brittany Wenger, Duke University, 2013-2014
  TIME’s Thirty Under Thirty
  
  Kelli Tomins, Duke University, 2014-2016
  Independent Study Student
  Current Position: Research Fellow, NIH
  
  Zachary Visco, Duke University, 2014-2017
  Current Position: Medical Student, State University of New York Medical School
  
  Michelle Dalson, Duke University, 2015
  
  Marie Boudreau, Appalachian State University, 2014 - 2017
  
  Sabrina Simpson, Boston University, 2015 - 2017
  
  Catherine Birtles, McGill University, 2015
  
  Ethan Whitaker, Cambell University, 2015 - 2017
  
  Melody Iro, Duke University, 2016
  
  Brad Foster, Duke University, 2016
  
  Kamyar Yazdani, Duke University Class of 2020, 2016 - 2019
  Independent Study Student
  
  Katarina Stephan, Duke University, 2017
  
  Katherine Maitland, Duke University Class of 2021, 2017 – 2018
  Independent Study Student, Biology Honors Research, Graduation with Distinction
  
  Olivia Neely, Duke University Class of 2020, 2018 – 2020
  Independent Study Student
  
  Jim Liu, Duke University Class of 2019
  Independent Study Student
  
  Kaycie Hutcheson, Duke University Class of 2020
  
  Michael Williams, Duke University Class of 2021
  
  Bailey Knight, Duke University 2021
  
  Isabella Coogan, Duke University 2021
  
  Parmida Jamshidi, Duke University Class of 2022
  
  Jun Hee Shin, Vanderbilt University, class of 2024
  
  Sarah Tan, Duke University, class of 2022
  
  Laura Boyle, Duke University, class of 2024
  
  High School Students
  
  Danielle Dejournet, North Carolina School of Science and Math, 2013-2014
  Kennedy Bridges, North Carolina School of Science and Math, 2014-2015
  Deepika Senthil, North Carolina School of Science and Math, 2015-2016
  Esther Son, North Carolina School of Science and Math, 2017-2018
  Andy Liu, North Carolina School of Science and Math, 2018-2019
  Jun Hee Shin, North Carolina School of Science and Math, 2019-2020, NCSSM Mentorship Program
  Imani Ermeus, Peddie School high school in Hightstown, New Jersey
  Derek Yao, Chapel Hill High School, North Carolina, 2019-2020
  Asiyat Gadzhimagomedova, Peddie School high school in Hightstown, New Jersey
Teaching Activities
- PATH 786.01 / Duke Merits: 2016
  PATH 786.01 / Duke Merits: 2013
  Guest lecturer, Introduction to Histology and Virtual Microscopy, 2018
  Guest lecturer, Cell Injury, Death, and Inflammation, 2018
  1985-1993, Pathology Instructor, North China Medical University, China
Scholarly, Clinical, & Service Activities
Presentations & Appearances
- Preclinoical Study of Recurrent Ovarian Cancer in Mouse Model. DCI monthly seminar. Duke Cancer Institute (DCI). February 27, 2017 2017
Service to the Profession
Service to Duke
- Treats for Teams. The Division of Reproductive Sciences assembled gift baskets and distributed to Duke health care workers on the front line of the COVID-19 pandemic. . Division of Reproductive Sciences, Department of Ob/Gyn, Duke University. April 2020 2020
- Attendance and Donation. Fundraising event for the Duke OB/GYN Division of Gynecologic Oncology. Gail Parkins Ovarian Cancer Awareness Walk. 2011 - 2019 2011 - 2019

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Education, Training, & Certifications

Duke Appointment History

Academic Positions Outside Duke

Awards & Honors

Selected Grants

Fellowships, Supported Research, & Other Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers

Datasets

Recent Courses

Advising & Mentoring

Teaching Activities

Presentations & Appearances

Service to the Profession

Service to Duke