Scholars@Duke

• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Do, E. K., N. L. Zucker, Z. Y. Huang, J. C. Schechter, S. H. Kollins, R. L. Maguire, S. K. Murphy, C. Hoyo, and B. F. Fuemmeler. “Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children..” Pediatric Obesity 14, no. 2 (February 2019). https://doi.org/10.1111/ijpo.12454.
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    • Kantor, Boris, Lidia Tagliafierro, Jeffrey Gu, Madison E. Zamora, Ekaterina Ilich, Carole Grenier, Zhiqing Y. Huang, Susan Murphy, and Ornit Chiba-Falek. “Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD..” Molecular Therapy : The Journal of the American Society of Gene Therapy 26, no. 11 (November 2018): 2638–49. https://doi.org/10.1016/j.ymthe.2018.08.019.
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    • Gomih, Ayodele, Jennifer S. Smith, Kari E. North, Michael G. Hudgens, Wendy R. Brewster, Zhiqing Huang, David Skaar, et al. “DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions..” International Journal of Cancer 143, no. 3 (August 2018): 552–60. https://doi.org/10.1002/ijc.31350.
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    • House, John S., Michelle Mendez, Rachel L. Maguire, Sarah Gonzalez-Nahm, Zhiqing Huang, Julie Daniels, Susan K. Murphy, Bernard F. Fuemmeler, Fred A. Wright, and Cathrine Hoyo. “Periconceptional Maternal Mediterranean Diet Is Associated With Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted Genes..” Frontiers in Cell and Developmental Biology 6 (January 2018). https://doi.org/10.3389/fcell.2018.00107.
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    • Murphy, Susan K., Nilda Itchon-Ramos, Zachary Visco, Zhiqing Huang, Carole Grenier, Rose Schrott, Kelly Acharya, et al. “Cannabinoid exposure and altered DNA methylation in rat and human sperm..” Epigenetics 13, no. 12 (2018): 1208–21. https://doi.org/10.1080/15592294.2018.1554521.
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    • Cordero, Francisco J., Zhiqing Huang, Carole Grenier, Xingyao He, Guo Hu, Roger E. McLendon, Susan K. Murphy, Rintaro Hashizume, and Oren J. Becher. “Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG..” Molecular Cancer Research : Mcr 15, no. 9 (September 2017): 1243–54. https://doi.org/10.1158/1541-7786.MCR-16-0389.
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    • Liu, Yongmei, Lindsay M. Reynolds, Jingzhong Ding, Li Hou, Kurt Lohman, Tracey Young, Wei Cui, et al. “Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis..” Nature Communications 8, no. 1 (August 30, 2017). https://doi.org/10.1038/s41467-017-00517-4.
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    • McCullough, Lauren E., Erline E. Miller, Laura E. Calderwood, Nitin Shivappa, Susan E. Steck, Michele R. Forman, Michelle A Mendez, et al. “Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?.” Epigenetics 12, no. 8 (August 2017): 688–97. https://doi.org/10.1080/15592294.2017.1347241.
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    • Dewi, Fitriya N., Charles E. Wood, Cynthia J. Willson, Thomas C. Register, Cynthia J. Lees, Timothy D. Howard, Zhiqing Huang, et al. “Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques..” Cancer Prevention Research (Philadelphia, Pa.) 9, no. 5 (May 2016): 385–95. https://doi.org/10.1158/1940-6207.CAPR-15-0165.
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    • Fuemmeler, Bernard F., Chien-Ti Lee, Adelheid Soubry, Edwin S. Iversen, Zhiqing Huang, Amy P. Murtha, Joellen M. Schildkraut, Randy L. Jirtle, Susan K. Murphy, and Cathrine Hoyo. “DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament..” Genetics & Epigenetics 8 (January 2016): 59–67. https://doi.org/10.4137/GEG.S40538.
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    • Soubry, Adelheid, Lisa Guo, Zhiqing Huang, Cathrine Hoyo, Stephanie Romanus, Thomas Price, and Susan K. Murphy. “Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study..” Clinical Epigenetics 8 (January 2016). https://doi.org/10.1186/s13148-016-0217-2.
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    • Su, Dan, Xuting Wang, Michelle R. Campbell, Devin K. Porter, Gary S. Pittman, Brian D. Bennett, Ma Wan, et al. “Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes..” Plos One 11, no. 12 (January 2016). https://doi.org/10.1371/journal.pone.0166486.
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    • Sachdeva, Mohit, Rebecca D. Dodd, Zhiqing Huang, Carole Grenier, Yan Ma, Dina C. Lev, Diana M. Cardona, Susan K. Murphy, and David G. Kirsch. “Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182..” Cancer Letters 369, no. 1 (December 2015): 202–11. https://doi.org/10.1016/j.canlet.2015.08.016.
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    • Varadaraj, Archana, Pratik Patel, Anne Serrao, Tirthankar Bandyopadhay, Nam Y. Lee, Amir A. Jazaeri, Zhiqing Huang, Susan K. Murphy, and Karthikeyan Mythreye. “Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia..” Neoplasia 17, no. 11 (November 2015): 826–38. https://doi.org/10.1016/j.neo.2015.11.003.
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    • Keenan, Melissa M., Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D. Stevens, Olga Ilkayeva, et al. “ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate..” Plos Genetics 11, no. 10 (October 9, 2015). https://doi.org/10.1371/journal.pgen.1005599.
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    • Ding, Jingzhong, Lindsay M. Reynolds, Tanja Zeller, Christian Müller, Kurt Lohman, Barbara J. Nicklas, Stephen B. Kritchevsky, et al. “Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease..” Diabetes 64, no. 10 (October 2015): 3464–74. https://doi.org/10.2337/db14-1314.
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    • Murphy, Susan K., Erin Erginer, Zhiqing Huang, Zachary Visco, and Cathrine Hoyo. “Genotype-Epigenotype Interaction at the IGF2 DMR..” Genes 6, no. 3 (August 28, 2015): 777–89. https://doi.org/10.3390/genes6030777.
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    • Vidal, Adriana C., Viktoriya Semenova, Thomas Darrah, Avner Vengosh, Zhiqing Huang, Katherine King, Monica D. Nye, et al. “Maternal cadmium, iron and zinc levels, DNA methylation and birth weight..” Bmc Pharmacology & Toxicology 16 (July 15, 2015). https://doi.org/10.1186/s40360-015-0020-2.
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    • Mo, Lihong, Vendula Pospichalova, Zhiqing Huang, Susan K. Murphy, Sturgis Payne, Fang Wang, Margaret Kennedy, et al. “Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells..” Plos One 10, no. 7 (January 2015). https://doi.org/10.1371/journal.pone.0131579.
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    • Soubry, A., S. K. Murphy, F. Wang, Z. Huang, A. C. Vidal, B. F. Fuemmeler, J. Kurtzberg, et al. “Newborns of obese parents have altered DNA methylation patterns at imprinted genes.” International Journal of Obesity 39, no. 4 (January 1, 2015): 650–57. https://doi.org/10.1038/ijo.2013.193.
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    • Hoyo, Cathrine, Anne Kjersti Daltveit, Edwin Iversen, Sara E. Benjamin-Neelon, Bernard Fuemmeler, Joellen Schildkraut, Amy P. Murtha, et al. “Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort..” Epigenetics 9, no. 8 (August 2014): 1120–30. https://doi.org/10.4161/epi.29332.
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    • Yamaguchi, K., Z. Huang, N. Matsumura, M. Mandai, T. Okamoto, T. Baba, I. Konishi, A. Berchuck, and S. K. Murphy. “Epigenetic determinants of ovarian clear cell carcinoma biology.” International Journal of Cancer 135, no. 3 (August 1, 2014): 585–97. https://doi.org/10.1002/ijc.28701.
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    • Vidal, A. C., N. M. Henry, S. K. Murphy, O. Oneko, M. Nye, J. A. Bartlett, F. Overcash, et al. “PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer.” Clinical and Translational Oncology 16, no. 3 (March 1, 2014): 266–72. https://doi.org/10.1007/s12094-013-1067-4.
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    • Vidal, Adriana C., Sara E. Benjamin Neelon, Ying Liu, Abbas M. Tuli, Bernard F. Fuemmeler, Cathrine Hoyo, Amy P. Murtha, et al. “Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans..” Genetics & Epigenetics 6 (January 2014): 37–44. https://doi.org/10.4137/GEG.S18067.
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    • Vidal, A. C., S. K. Murphy, A. P. Murtha, J. M. Schildkraut, A. Soubry, Z. Huang, S. E. B. Neelon, et al. “Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring..” International Journal of Obesity (2005) 37, no. 7 (July 2013): 907–13. https://doi.org/10.1038/ijo.2013.47.
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    • Liu, Ying, Cathrine Hoyo, Susan Murphy, Zhiqing Huang, Francine Overcash, Jennifer Thompson, Haywood Brown, and Amy P. Murtha. “DNA methylation at imprint regulatory regions in preterm birth and infection..” Am J Obstet Gynecol 208, no. 5 (May 2013): 395.e1-395.e7. https://doi.org/10.1016/j.ajog.2013.02.006.
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    • Soubry, Adelheid, Joellen M. Schildkraut, Amy Murtha, Frances Wang, Zhiqing Huang, Autumn Bernal, Joanne Kurtzberg, Randy L. Jirtle, Susan K. Murphy, and Cathrine Hoyo. “Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort..” Bmc Medicine 11 (February 6, 2013). https://doi.org/10.1186/1741-7015-11-29.
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    • Alvarez Secord, Angeles, Marcus Q. Bernardini, Gloria Broadwater, Lisa A. Grace, Zhiqing Huang, Tsukasa Baba, Eiji Kondoh, Gregory Sfakianos, Laura J. Havrilesky, and Susan K. Murphy. “TP53 Status is Associated with Thrombospondin1 Expression In vitro..” Frontiers in Oncology 3 (January 2013). https://doi.org/10.3389/fonc.2013.00269.
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    • Bassil, Christopher F., Zhiqing Huang, and Susan K. Murphy. “Bisulfite pyrosequencing..” Methods in Molecular Biology (Clifton, N.J.) 1049 (January 2013): 95–107. https://doi.org/10.1007/978-1-62703-547-7_9.
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    • Huang, Zhiqing, Christopher F. Bassil, and Susan K. Murphy. “Bisulfite sequencing of cloned alleles..” Methods in Molecular Biology (Clifton, N.J.) 1049 (January 2013): 83–94. https://doi.org/10.1007/978-1-62703-547-7_8.
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    • Huang, Zhiqing, Christopher F. Bassil, and Susan K. Murphy. “Methylation-specific PCR..” Methods in Molecular Biology (Clifton, N.J.) 1049 (January 2013): 75–82. https://doi.org/10.1007/978-1-62703-547-7_7.
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    • Huang, Zhiqing, and Susan K. Murphy. “Increased Intragenic IGF2 Methylation is Associated with Repression of Insulator Activity and Elevated Expression in Serous Ovarian Carcinoma..” Frontiers in Oncology 3 (January 2013). https://doi.org/10.3389/fonc.2013.00131.
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    • Murphy, Susan K., Christopher F. Bassil, and Zhiqing Huang. “Main principles and outcomes of DNA methylation analysis..” Methods in Molecular Biology (Clifton, N.J.) 1049 (January 2013): 67–74. https://doi.org/10.1007/978-1-62703-547-7_6.
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    • Nye, Monica D., Cathrine Hoyo, Zhiqing Huang, Adriana C. Vidal, Frances Wang, Francine Overcash, Jennifer S. Smith, et al. “Associations between methylation of paternally expressed gene 3 (PEG3), cervical intraepithelial neoplasia and invasive cervical cancer..” Plos One 8, no. 2 (2013). https://doi.org/10.1371/journal.pone.0056325.
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    • Joubert, Bonnie R., Siri E. Håberg, Roy M. Nilsen, Xuting Wang, Stein E. Vollset, Susan K. Murphy, Zhiqing Huang, et al. “450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy..” Environmental Health Perspectives 120, no. 10 (October 2012): 1425–31. https://doi.org/10.1289/ehp.1205412.
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    • Liu, Ying, Susan K. Murphy, Amy P. Murtha, Bernard F. Fuemmeler, Joellen Schildkraut, Zhiqing Huang, Francine Overcash, et al. “Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements..” Epigenetics 7, no. 7 (July 2012): 735–46. https://doi.org/10.4161/epi.20734.
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    • Perkins, Ellen, Susan K. Murphy, Amy P. Murtha, Joellen Schildkraut, Randy L. Jirtle, Wendy Demark-Wahnefried, Michele R. Forman, et al. “Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children..” The Journal of Pediatrics 161, no. 1 (July 2012): 31–39. https://doi.org/10.1016/j.jpeds.2012.01.015.
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    • Hoyo, Cathrine, Kimberly Fortner, Amy P. Murtha, Joellen M. Schildkraut, Adelheid Soubry, Wendy Demark-Wahnefried, Randy L. Jirtle, et al. “Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight..” Cancer Causes & Control : Ccc 23, no. 4 (April 2012): 635–45. https://doi.org/10.1007/s10552-012-9932-y.
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    • Murphy, Susan K., Abayomi Adigun, Zhiqing Huang, Francine Overcash, Frances Wang, Randy L. Jirtle, Joellen M. Schildkraut, Amy P. Murtha, Edwin S. Iversen, and Cathrine Hoyo. “Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke..” Gene 494, no. 1 (February 2012): 36–43. https://doi.org/10.1016/j.gene.2011.11.062.
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    • Murphy, Susan K., Zhiqing Huang, and Cathrine Hoyo. “Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues..” Plos One 7, no. 7 (January 2012). https://doi.org/10.1371/journal.pone.0040924.
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    • Yamamura, Shogo, Noriomi Matsumura, Masaki Mandai, Zhiqing Huang, Tomonori Oura, Tsukasa Baba, Junzo Hamanishi, et al. “The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer..” International Journal of Cancer 130, no. 1 (January 2012): 20–28. https://doi.org/10.1002/ijc.25961.
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    • Bondurant, Amy E., Zhiqing Huang, Regina S. Whitaker, Lauren R. Simel, Andrew Berchuck, and Susan K. Murphy. “Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer..” Gynecol Oncol 123, no. 3 (December 2011): 581–87. https://doi.org/10.1016/j.ygyno.2011.08.029.
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    • Alvarez Secord, Angeles, Kathleen M. Darcy, Alan Hutson, Zhiqing Huang, Paula S. Lee, Elizabeth L. Jewell, Laura J. Havrilesky, Maurie Markman, Franco Muggia, and Susan K. Murphy. “The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study..” Gynecologic Oncology 123, no. 2 (November 2011): 314–19. https://doi.org/10.1016/j.ygyno.2011.08.003.
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    • Soubry, A., Sk Murphy, Z. Huang, A. Murtha, Jm Schildkraut, Rl Jirtle, F. Wang, et al. “The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring..” Clinical Epigenetics 3 (October 26, 2011). https://doi.org/10.1186/1868-7083-3-2.
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    • Hoyo, Cathrine, Amy P. Murtha, Joellen M. Schildkraut, Randy L. Jirtle, Wendy Demark-Wahnefried, Michele R. Forman, Edwin S. Iversen, et al. “Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy..” Epigenetics 6, no. 7 (July 2011): 928–36. https://doi.org/10.4161/epi.6.7.16263.
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    • Matsumura, Noriomi, Zhiqing Huang, Seiichi Mori, Tsukasa Baba, Shingo Fujii, Ikuo Konishi, Edwin S. Iversen, Andrew Berchuck, and Susan K. Murphy. “Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer..” Genome Res 21, no. 1 (January 2011): 74–82. https://doi.org/10.1101/gr.108803.110.
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    • Lee, Paula S., Vanessa S. Teaberry, Amy E. Bland, Zhiqing Huang, Regina S. Whitaker, Tsukasa Baba, Shingo Fujii, Angeles Alvarez Secord, Andrew Berchuck, and Susan K. Murphy. “Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer..” International Journal of Cancer 126, no. 6 (March 2010): 1378–89. https://doi.org/10.1002/ijc.24797.
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    • Ding, X., A. B. Mohd, Z. Huang, T. Baba, M. Q. Bernardini, H. K. Lyerly, A. Berchuck, S. K. Murphy, A. B. Buermeyer, and G. R. Devi. “MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition..” Br J Cancer 101, no. 2 (July 21, 2009): 269–77. https://doi.org/10.1038/sj.bjc.6605180.
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    • Matsumura, Noriomi, Zhiqing Huang, Tsukasa Baba, Paula S. Lee, Jason C. Barnett, Seiichi Mori, Jeffrey T. Chang, et al. “Yin yang 1 modulates taxane response in epithelial ovarian cancer..” Molecular Cancer Research : Mcr 7, no. 2 (February 10, 2009): 210–20. https://doi.org/10.1158/1541-7786.MCR-08-0255.
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    • Baba, T., P. A. Convery, N. Matsumura, R. S. Whitaker, E. Kondoh, T. Perry, Z. Huang, et al. “Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells..” Oncogene 28, no. 2 (January 15, 2009): 209–18. https://doi.org/10.1038/onc.2008.374.
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    • Schildkraut, Joellen M., Susan K. Murphy, Rachel T. Palmieri, Edwin Iversen, Patricia G. Moorman, Zhiqing Huang, Susan Halabi, et al. “Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer..” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 16, no. 3 (March 2007): 473–80. https://doi.org/10.1158/1055-9965.epi-06-0868.
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    • Murphy, Susan K., Zhiqing Huang, Yaqing Wen, Monique A. Spillman, Regina S. Whitaker, Lauren R. Simel, Teresa D. Nichols, Jeffrey R. Marks, and Andrew Berchuck. “Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer..” Molecular Cancer Research : Mcr 4, no. 4 (April 2006): 283–92. https://doi.org/10.1158/1541-7786.mcr-05-0138.
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    • Murphy, Susan K., Catherine M. Nolan, Zhiqing Huang, Katerina S. Kucera, Brad A. Freking, Timothy P. L. Smith, Kreg A. Leymaster, Jennifer R. Weidman, and Randy L. Jirtle. “Callipyge mutation affects gene expression in cis: a potential role for chromatin structure..” Genome Research 16, no. 3 (March 2006): 340–46. https://doi.org/10.1101/gr.4389306.
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    • Huang, Zhiqing, Yaqing Wen, Ruby Shandilya, Jeffrey R. Marks, Andrew Berchuck, and Susan K. Murphy. “High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer..” Nucleic Acids Research 34, no. 2 (January 23, 2006): 555–63. https://doi.org/10.1093/nar/gkj468.
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    • Gollob, Jared A., Catherine J. Sciambi, Zhiqing Huang, and Holly K. Dressman. “Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma..” Cancer Res 65, no. 19 (October 1, 2005): 8869–77. https://doi.org/10.1158/0008-5472.CAN-05-1387.
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  • Conference Papers

    • Tindula, Gwen, Susan K. Murphy, Carole Grenier, Zhiqing Huang, Karen Huen, Maria Escudero-Fung, Asa Bradman, Brenda Eskenazi, Cathrine Hoyo, and Nina Holland. “DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure..” In Epigenomics, 10:1011–26, 2018. https://doi.org/10.2217/epi-2017-0178.
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