Lexie Zidanyue Yang

Journal Article Am J Epidemiol · March 4, 2025 There is a profound need to identify modifiable risk factors to screen and prevent pancreatic cancer. Air pollution, including fine particulate matter (PM2.5), is increasingly recognized as a risk factor for cancer. We conducted a case-control study using ... Full text Link to item Cite

Evaluation of Tacrolimus Concentrations and Clinical Outcomes Between Extended and Immediate Release Formulations in Kidney Transplant.

Journal Article J Pharm Pract · December 2024 Objectives: Tacrolimus remains the mainstay of immunosuppression in kidney transplantation. Understanding the relationship between therapeutic tacrolimus levels and outcomes of acute rejection, patient/graft survival, and tolerability are important. The re ... Full text Link to item Cite

Disparities in the treatment of movement disorders using deep brain stimulation.

Journal Article J Neurosurg · July 1, 2024 OBJECTIVE: Deep brain stimulation (DBS) is a well-established treatment for Parkinson's disease (PD) and essential tremor (ET). Although the prevalence of PD and ET can vary by sex and race, little is known about the accessibility of neurosurgical treatmen ... Full text Link to item Cite

Disparities in Access to Deep Brain Stimulation and Responsive Neurostimulation Approaches to Drug-Resistant Epilepsy.

Journal Article Neuromodulation · June 2024 BACKGROUND: Epilepsy affects 1% to 2% of the global population, and those who are resistant to medical treatment may be candidates for neuromodulation. In select populations, brain stimulation approaches including deep brain stimulation (DBS) and responsiv ... Full text Link to item Cite

Demographics of focused ultrasound thalamotomy for essential tremor and trends in deep brain stimulation surgery after its introduction in the USA

Journal Article BMJ Neurology Open · April 10, 2024 Background Essential tremor (ET) is a movement disorder that affects 4%-5% of adults >65 years. For patients with medically refractory ET, neurosurgical interventions such as deep brain stimulation (DBS) and unilateral MR-guided focused ultrasound thalamot ... Full text Cite

Healthcare resource utilization for chronic low back pain among high-utilizers.

Journal Article Spine J · April 2024 BACKGROUND: Chronic low back pain is a leading cause of morbidity and is among the largest cost drivers for the healthcare system. Research on healthcare resource utilization of patients with low back pain who are not surgical candidates is limited, and fe ... Full text Link to item Cite

Two-Year Clinical and Radiographic Outcomes for Percutaneous Lumbar Interbody Fusion With an Expandable Titanium Cage Through Kambin's Triangle Without Facetectomy.

Journal Article Int J Spine Surg · December 26, 2023 BACKGROUND: There has been heightened interest in performing percutaneous lumbar interbody fusions (percLIFs) through Kambin's triangle, an anatomic corridor allowing entrance into the disc space. However, due to its novelty, there are limited data regardi ... Full text Open Access Link to item Cite

Utility of Routine Preoperative Urinalysis in the Prevention of Surgical Site Infections.

Journal Article World Neurosurg · December 2023 OBJECTIVE: Preoperative assessment is important for neurosurgical risk stratification, but the level of evidence for individual screening tests is low. In preoperative urinalysis (UA), testing may significantly increase costs and lead to inappropriate anti ... Full text Link to item Cite

Short-Term Health Care Costs of High-Frequency Spinal Cord Stimulation for the Treatment of Postsurgical Persistent Spinal Pain Syndrome.

Journal Article Neuromodulation · October 2023 OBJECTIVE: High-frequency spinal cord stimulation (HF-SCS) is a treatment option for postsurgical persistent spinal pain syndrome (type 2 PSPS). We aimed to determine the health care costs associated with this therapy in a nationwide cohort. MATERIALS AND ... Full text Link to item Cite

Clinical Utility of Near-Infrared Device in Detecting Traumatic Intracranial Hemorrhage: A Pilot Study Toward Application as an Emergent Diagnostic Modality in a Low-Resource Setting.

Journal Article J Neurotrauma · August 2023 Limited computed tomography (CT) availability in low- and middle-income countries frequently impedes life-saving neurosurgical decompression for traumatic brain injury. A reliable, accessible, cost-effective solution is necessary to detect and localize ble ... Full text Link to item Cite

Needles in a Haystack: Finding Qualitative and Quantitative Collaborators in Academic Medical Centers.

Journal Article Acad Med · August 1, 2023 Translational research is a data-driven process that involves transforming scientific laboratory- and clinic-based discoveries into products and activities with real-world impact to improve individual and population health. Successful execution of translat ... Full text Link to item Cite

Assessment of Health Care Costs and Total Baclofen Use Associated With Targeted Drug Delivery for Spasticity.

Journal Article Neuromodulation · August 2023 BACKGROUND: Chronic spasticity causes significant impairment and financial burden. Oral baclofen, the first-line therapy, can have intolerable, dose-dependent side effects. Targeted drug delivery (TDD) through intrathecal baclofen delivers smaller amounts ... Full text Link to item Cite

Quantifying the Opportunity Cost of Neurosurgical Resident Education.

Journal Article World Neurosurg · July 2023 BACKGROUND/OBJECTIVE: Education is at the core of neurosurgical residency, but little research in to the cost of neurosurgical education exists. This study aimed to quantify costs of resident education in an academic neurosurgery program using traditional ... Full text Link to item Cite

Evaluation of Levetiracetam Dosing Strategies for Seizure Prophylaxis Following Traumatic Brain Injury.

Conference Neurocrit Care · April 2023 BACKGROUND: Although levetiracetam has been increasingly used as an alternative to phenytoin for early posttraumatic seizure prophylaxis following traumatic brain injury (TBI), an optimal dosing strategy has not been elucidated. The objective of this study ... Full text Link to item Cite

Evaluation of Weight-Based Dose During Transition From Immediate-Release to Extended-Release Tacrolimus in Kidney Transplant Recipients.

Journal Article J Pharm Pract · February 2023 BACKGROUND: Manufacturer recommendations for conversion from immediate-release to extended-release tacrolimus, Envarsus XR®, suggests 80% of the total daily dose of the immediate-release formulation. This conversion has not consistently achieved therapeuti ... Full text Link to item Cite

Health Care Resource Utilization of High-Frequency Spinal Cord Stimulation for Treatment of Chronic Refractory Low Back Pain.

Journal Article Neuromodulation · January 2023 INTRODUCTION: Chronic refractory low back pain (CRLBP) is a diagnosis characterized by chronic low back pain in patients who are poor candidates for surgery and fail conservative management. High-frequency spinal cord stimulation (HF-SCS) is a new advance ... Full text Link to item Cite

Revisiting flow augmentation bypass for cerebrovascular atherosclerotic vaso-occlusive disease: Single-surgeon series and review of the literature.

Journal Article PLoS One · 2023 OBJECTIVE: Despite advances in the nonsurgical management of cerebrovascular atherosclerotic steno-occlusive disease, approximately 15-20% of patients remain at high risk for recurrent ischemia. The benefit of revascularization with flow augmentation bypas ... Full text Link to item Cite

Experiential Learning Methods for Biostatistics Students: A Model for Embedding Student Interns in Academic Health Centers.

Journal Article Stat · December 2022 This manuscript describes an experiential learning program for future collaborative biostatisticians (CBs) developed within an academic medical center. The program is a collaborative effort between the Biostatistics, Epidemiology, and Research Design (BERD ... Full text Link to item Cite

Association between Gentrification and Health and Healthcare Utilization.

Journal Article J Urban Health · December 2022 There is tremendous interest in understanding how neighborhoods impact health by linking extant social and environmental drivers of health (SDOH) data with electronic health record (EHR) data. Studies quantifying such associations often use static neighbor ... Full text Link to item Cite

Classification of older adults who underwent lumbar-related surgery using pre-operative biopsychosocial predictors and relationships with surgical recovery: An observational study conducted in the United States.

Journal Article Health Soc Care Community · September 2022 Lumbar surgery is a commonly prescribed intervention for low back pain but poses higher risks and worse outcomes for older adults. Identifying clinical phenotypes based on biopsychosocial factors may help identify older adults who are at greatest risk for ... Full text Link to item Cite

Early versus delayed initiation of cytomegalovirus prophylaxis after liver transplant.

Journal Article Pharmacotherapy · August 2022 ObjectivesDelaying cytomegalovirus (CMV) prophylaxis after liver transplantation may limit medication side effects and reduce inpatient drug costs. The primary objective of this study was to determine the incidence of CMV DNAemia in liver transpla ... Full text Cite

Palliative Care Consultations in Patients with Severe Traumatic Brain Injury: Who Receives Palliative Care Consultations and What Does that Mean for Utilization?

Journal Article Neurocrit Care · June 2022 BACKGROUND: Palliative care has the potential to improve goal-concordant care in severe traumatic brain injury (sTBI). Our primary objective was to illuminate the demographic profiles of patients with sTBI who receive palliative care encounters (PCEs), wit ... Full text Open Access Link to item Cite

Novel ADAMTS13 mutation in a family with three recurrent neonatal deaths: a case report and literature review.

Journal Article Translational pediatrics · May 2022 BackgroundUpshaw-Schulman syndrome (USS) is rare, autosomal recessive, hereditary thrombotic thrombocytopenic purpura (TTP) caused by variants in a disintegrin-like and metalloprotease with thrombospondin type 1 motif (ADAMTS13). USS has a ... Full text Cite

Congenital Human Cytomegalovirus Infection Is Associated With Decreased Transplacental IgG Transfer Efficiency Due to Maternal Hypergammaglobulinemia.

Journal Article Clin Infect Dis · April 9, 2022 BACKGROUND: Placentally transferred maternal immunoglobulin G (IgG) protects against pathogens in early life, yet vertically transmitted infections can interfere with transplacental IgG transfer. Although human cytomegalovirus (HCMV) is the most common pla ... Full text Open Access Link to item Cite

Image Quality and Dose Comparison of 3 Mobile Intraoperative Three-Dimensional Imaging Systems in Spine Surgery.

Journal Article World Neurosurg · April 2022 OBJECTIVE: To evaluate radiation exposure and image quality (IQ) for 3 intraoperative imaging systems (Airo TruCT, Cios Spin, O-arm) using varying radiation dose settings in a single cadaveric model. METHODS: Axial images of L4-5 instrumentation were obtai ... Full text Open Access Link to item Cite

Association of tacrolimus time-to-therapeutic range on renal dysfunction and acute cellular rejection after orthotopic heart transplantation in a high use basiliximab population.

Journal Article Clin Transplant · March 2022 BACKGROUND: Currently, clinicians often delay initiation of tacrolimus after orthotopic heart transplantation (OHT) to help mitigate nephrotoxicity. This study aimed to determine if there is an association between the time-to-therapeutic range (TTT) of tac ... Full text Link to item Cite

Impact of Spinal Cord Stimulation on Opioid Dose Reduction: A Nationwide Analysis

Conference Neurosurgery · December 1, 2021 Full text Cite

Psychosocial determinants of cardiovascular events among black Americans with chronic kidney disease or associated risk factors in the Jackson heart study.

Journal Article BMC Nephrol · November 11, 2021 BACKGROUND: Individuals with chronic kidney disease (CKD), hypertension (HTN), or diabetes mellitus (DM) are at increased risk for cardiovascular disease (CVD). The extent to which psychosocial factors are associated with increased CVD risk within these in ... Full text Link to item Cite

Inpatient mortality and healthcare resource utilization of nontraumatic intracerebral hemorrhage complications in the US.

Journal Article J Neurosurg · October 1, 2021 OBJECTIVE: Nontraumatic, primary intracerebral hemorrhage (ICH) accounts for 2 million strokes worldwide annually and has a 1-year survival rate of 50%. Recent studies examining functional outcomes from ICH evacuation have been performed, but limited work ... Full text Link to item Cite

Completeness of reporting and risks of overstating impact in cluster randomised trials: a systematic review.

Journal Article Lancet Glob Health · August 2021 Overstating the impact of interventions through incomplete or inaccurate reporting can lead to inappropriate scale-up of interventions with low impact. Accurate reporting of the impact of interventions is of great importance in global health research to pr ... Full text Link to item Cite

Impact of US hospital center and interhospital transfer on spinal cord injury management: An analysis of the National Trauma Data Bank.

Journal Article J Trauma Acute Care Surg · June 1, 2021 BACKGROUND: Traumatic spinal cord injury (SCI) is a serious public health problem. Outcomes are determined by severity of immediate injury, mitigation of secondary downstream effects, and rehabilitation. This study aimed to understand how the center type a ... Full text Open Access Link to item Cite

Image quality of EOS low-dose radiography in comparison with conventional radiography for assessment of ventriculoperitoneal shunt integrity.

Journal Article J Neurosurg Pediatr · April 1, 2021 OBJECTIVE: Patients with shunted hydrocephalus often accumulate high levels of radiation over their lifetimes during evaluation of hardware integrity. Current practice involves the use of a series of conventional radiographs for this purpose. Newer low-dos ... Full text Link to item Cite

Effectiveness of Quetiapine as a Sedative Adjunct in Mechanically Ventilated Adults Without Delirium.

Journal Article Ann Pharmacother · February 2021 BACKGROUND: Quetiapine is an atypical antipsychotic that is commonly used in the Intensive Care Unit (ICU). The utility of quetiapine as a sedative adjunct has not yet been evaluated, but has been described previously in studies evaluating quetiapine for d ... Full text Link to item Cite

Impact of Spinal Cord Stimulation on Opioid Dose Reduction: A Nationwide Analysis.

Journal Article Neurosurgery · December 15, 2020 BACKGROUND: Opioid misuse in the USA is an epidemic. Utilization of neuromodulation for refractory chronic pain may reduce opioid-related morbidity and mortality, and associated economic costs. OBJECTIVE: To assess the impact of spinal cord stimulation (SC ... Full text Open Access Link to item Cite

Health care resource utilization and treatment of leptomeningeal carcinomatosis in the United States.

Journal Article Neurooncol Pract · December 2020 BACKGROUND: The economic burden of cancer in the United States is substantial, and better understanding it is essential in informing health care policy and innovation. Leptomeningeal carcinomatosis (LC) represents a late complication of primary cancer spre ... Full text Link to item Cite

Health Care Resource Utilization and Management of Chronic, Refractory Low Back Pain in the United States.

Journal Article Spine (Phila Pa 1976) · October 15, 2020 STUDY DESIGN:: Retrospective analysis of inpatient and outpatient medical insurance claims data from a database containing over 100 million individuals. OBJECTIVE:: To quantify the healthcare resource utilization (HCRU) of non-surgical treatments in the fi ... Full text Link to item Cite

Painful diabetic peripheral neuropathy: Health care costs and complications from 2010 to 2015.

Journal Article Neurol Clin Pract · February 2020 OBJECTIVE: To quantify health care resource utilization and risk of complications in painful diabetic peripheral neuropathy (pDPN). METHODS: Adult patients diagnosed with diabetes mellitus or diabetic peripheral neuropathy (DPN) were identified in MarketSc ... Full text Link to item Cite

Predictors of Clinical Outcome After Treatment of Intracranial Aneurysms with the Pipeline Embolization Device.

Journal Article World Neurosurg · October 2019 BACKGROUND: Flow-diverting stents have revolutionized the endovascular treatment of intracranial aneurysms. The purpose of this study is to identify predictors of adverse outcomes associated with the pipeline embolization device (PED). METHODS: A retrospec ... Full text Link to item Cite

Fibrin glue as an adjuvant dural sealant reduces the rate of perioperative complications in posterior fossa decompression with duraplasty: A single center experience in 165 adult Chiari I patients.

Journal Article J Clin Neurosci · October 2019 Full text Link to item Cite

Healthcare Resource Utilization of Complications of Intracerebral Hemorrhage

Journal Article Neurosurgery · September 2019 Full text Cite