Scholars@Duke
Zachary Kirk Wegermann

Zachary Kirk Wegermann

Assistant Professor of Medicine
Medicine, Cardiology

Selected Publications

Outcomes of Transcatheter Aortic Valve Replacement in Low-Risk Patients in the United States: A Report From the STS/ACC TVT Registry.

Journal Article Circulation · April 22, 2025 BACKGROUND: Real-world low-risk transcatheter aortic valve replacement (TAVR) outcomes in the United States have not been assessed comprehensively versus pivotal trials, which is a key component of measuring the quality of clinical technology adoption. MET ... Full text Link to item Cite

Ventricular Arrhythmias After Primary Percutaneous Coronary Intervention for STEMI.

Journal Article JAMA Netw Open · May 1, 2024 IMPORTANCE: Currently, mortality risk for patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) with an uncomplicated postprocedure course is low. Less is known regarding the risk of ... Full text Link to item Cite

Benchmarking Outcomes of Surgical Aortic Valve Replacement in Patients With Bicuspid Aortic Valves.

Journal Article Ann Thorac Surg · December 2023 BACKGROUND: The relative roles for transcatheter and surgical aortic valve replacement (SAVR) for bicuspid aortic valve (AV) stenosis are debated. This study analyzes the 5-year longitudinal outcomes of isolated SAVR in bicuspid vs tricuspid AV patients, p ... Full text Link to item Cite

Outcomes and Institutional Variation in Arterial Access Among Patients With AMI and Cardiogenic Shock Undergoing PCI.

Journal Article JACC Cardiovasc Interv · June 26, 2023 BACKGROUND: Contemporary data comparing the outcomes of transradial access (TRA) vs transfemoral access (TFA) among patients presenting with acute myocardial infarction and cardiogenic shock (AMI-CS) undergoing percutaneous coronary intervention (PCI) are ... Full text Link to item Cite

Challenge in Predicting Persistence to P2Y12 Inhibitors: A Perspective From the ARTEMIS Trial.

Journal Article J Am Heart Assoc · June 20, 2023 Background Premature discontinuation of P2Y12 inhibitor therapy has been associated with adverse cardiac events, which might be preventable by improving medication persistence. Current risk models have limited ability to predict patients at risk of P2Y12 i ... Full text Link to item Cite

Modeling the Association of Volume vs Composite Outcome Thresholds With Outcomes and Access to Transcatheter Aortic Valve Implantation in the US.

Journal Article JAMA Cardiol · May 1, 2023 IMPORTANCE: Professional societies and the Centers for Medicare & Medicaid Services suggest volume thresholds to ensure quality in transcatheter aortic valve implantation (TAVI). OBJECTIVE: To model the association of volume thresholds vs spoke-and-hub imp ... Full text Link to item Cite

Outcomes of acute type A aortic dissection during the COVID-19 pandemic: An analysis of the Society of Thoracic Surgeons Database.

Journal Article J Card Surg · December 2022 PURPOSE: There have been reported reductions of hospital presentation for acute cardiovascular conditions such as myocardial infarction and acute type A aortic dissection (ATAAD) in the United States during the COVID-19 pandemic. This study examined presen ... Full text Link to item Cite

Characteristics, Process Metrics, and Outcomes Among Patients With ST-Elevation Myocardial Infarction in Rural vs Urban Areas in the US: A Report From the US National Cardiovascular Data Registry.

Journal Article JAMA Cardiol · October 1, 2022 IMPORTANCE: Patients with ST-segment elevation myocardial infarction (STEMI) living in rural settings often have worse clinical outcomes compared with their urban counterparts. Whether this discrepancy is due to clinical characteristics or delays in timely ... Full text Link to item Cite

Association of Transcatheter Aortic Valve Replacement Reimbursement, New Technology Add-on Payment, and Procedure Volumes With Embolic Protection Device Use.

Journal Article JAMA Cardiol · September 1, 2022 IMPORTANCE: In the setting of uncertain efficacy and additional, unreimbursed cost, use of an embolic protection device (EPD) during transcatheter aortic valve replacement (TAVR) has had variable uptake. The Centers for Medicare & Medicaid Services (CMS) i ... Full text Link to item Cite

Abstract P1017: Tissue Engineered Human Acellular Blood Vessels For Coronary Artery Bypass Grafting

Conference Circulation Research · August 5, 2022 Objective: Conduit for coronary artery bypass grafting (CABG) can be limited due to poor quality or prior removal of saphenous veins. A human acellular vessel (HAV) bioengineered from vascular cells a ... Full text Cite

Strategies for Mechanical Right Ventricular Support During Left Ventricular Assist Device Implant.

Journal Article Ann Thorac Surg · August 2022 BACKGROUND: Refractory right ventricular failure at the time of left ventricular assist device implantation requires treatment with supplemental mechanical circulatory support. However, the optimal strategy for support remains unknown. METHODS: All patient ... Full text Link to item Cite

Anxiety and Depression Following Aortic Valve Replacement.

Journal Article J Am Heart Assoc · May 3, 2022 Background The aim of this study was to identify patients vulnerable for anxiety and/or depression following aortic valve replacement (AVR) and to evaluate factors that may mitigate this risk. Methods and Results This is a retrospective cohort study conduc ... Full text Link to item Cite

Sex Differences in Management and Outcomes of Acute Myocardial Infarction Patients Presenting With Cardiogenic Shock.

Journal Article JACC Cardiovasc Interv · March 28, 2022 OBJECTIVES: The aim of this study was to examine the sex differences in the risk profile, management, and outcomes among patients presenting with acute myocardial infarction cardiogenic shock (AMI-CS). BACKGROUND: Contemporary clinical data regarding sex d ... Full text Link to item Cite

Aortic Annular Enlargement in the Elderly: Short and Long-Term Outcomes in the United States.

Conference Ann Thorac Surg · October 2021 BACKGROUND: Patient prosthesis mismatch is associated with significant long-term morbidity and mortality after aortic valve replacement, but the role and outcomes of annular enlargement (AE) remain poorly defined. We hypothesized that increasing rates of A ... Full text Link to item Cite

Transesophageal Echocardiography in Patients Undergoing Coronary Artery Bypass Graft Surgery.

Journal Article J Am Coll Cardiol · July 13, 2021 BACKGROUND: The impact of utilization of intraoperative transesophageal echocardiography (TEE) at the time of isolated coronary artery bypass grafting (CABG) on clinical decision making and associated outcomes is not well understood. OBJECTIVES: The purpos ... Full text Link to item Cite

Quo Vadis, Bleeding Risk Models?

Journal Article JACC Cardiovasc Interv · June 14, 2021 Full text Link to item Cite

Site-Level Variability in 30-Day Patient Outcomes After Transcatheter Mitral Valve Repair in the United States.

Journal Article Circ Cardiovasc Qual Outcomes · December 2020 BACKGROUND: Clinical trials have demonstrated health status benefit of transcatheter mitral valve repair (TMVr) with MitraClip in patients with mitral valve regurgitation. Real-world site-level variability in health status outcomes for TMVr, and factors as ... Full text Link to item Cite

Currently Available Options for Mechanical Circulatory Support for the Management of Cardiogenic Shock.

Journal Article Cardiol Clin · November 2020 Cardiogenic shock (CS) is a complex condition with a high risk for morbidity and mortality. Mechanical circulatory support (MCS) devices were developed to support patients with CS in cases refractory to treatment with vasoactive medications. Current device ... Full text Link to item Cite

Navigation of a Dormant AV Fistula for PCI in a Patient With High-Risk NSTEMI.

Journal Article JACC Case Rep · September 2020 Arteriovenous (AV) fistulae for hemodialysis in patients with end-stage renal disease usually prevents ipsilateral transradial access (TRA) for coronary angiography. We present a case of coronary angiography and percutaneous coronary intervention via left ... Full text Link to item Cite

Complications involving the subcutaneous implantable cardioverter-defibrillator: Lessons learned from MAUDE.

Journal Article Heart Rhythm · March 2020 BACKGROUND: Reports on the subcutaneous implantable cardioverter-defibrillator (S-ICD) cumulatively demonstrate a low rate of complications, but clinical experience with this technology is limited compared with transvenous devices. OBJECTIVE: The purpose o ... Full text Link to item Cite

Cath Lab Robotics: Paradigm Change in Interventional Cardiology?

Journal Article Curr Cardiol Rep · August 31, 2019 PURPOSE OF REVIEW: To review the contemporary evidence for robotic-assisted percutaneous coronary and vascular interventions, discussing its current capabilities, limitations, and potential future applications. RECENT FINDINGS: Robotic-assisted cardiovascu ... Full text Link to item Cite

Related or not? Development of spontaneous Creutzfeldt-Jakob disease in a patient with chronic, well-controlled HIV: A case report and review of the literature.

Journal Article SAGE Open Med Case Rep · 2016 BACKGROUND: We report a novel case of a rare disease: spontaneous Creutzfeldt-Jakob disease in a patient with well-controlled HIV. We explore the relationship between spontaneous Creutzfeldt-Jakob disease and HIV. CASE REPORT: A 66-year-old man with long-s ... Full text Link to item Cite