Skip to main content

Abstract P1017: Tissue Engineered Human Acellular Blood Vessels For Coronary Artery Bypass Grafting

Publication ,  Conference
Williams, AR; Nellis, J; Wegermann, Z; McCartney, S; Podgoreanu, MV; Mehta, S; Williams, KD; Daubert, MA; Kirkton, R; Nash, K; Niklason, L ...
Published in: Circulation Research
August 5, 2022

Conduit for coronary artery bypass grafting (CABG) can be limited due to poor quality or prior removal of saphenous veins. A human acellular vessel (HAV) bioengineered from vascular cells and then decellularized for implantation may provide a readily available, off-the-shelf conduit for CABG. Here we evaluate the use of small diameter HAV for CABG in a non-human primate model. Adult male baboons (n=7; 26.8 - 37.0 kg) were imaged by left heart catheterization and computed tomography angiography. CABG was performed using a 3.5 mm diameter HAV to the left anterior descending (LAD) or right coronary artery (RCA) via sternotomy with cardiopulmonary bypass. The proximal coronary artery was ligated to prevent competitive flow and graft transit time flowmetry (TTFM) was assessed after implant. Angiography at 2 weeks, 1, 3, and 6 months evaluated graft patency and heart function. HAVs explanted at 6 months were assessed by immunohistochemistry for host cellular response and remodeling. Baboons underwent CABG using a 3.5 mm HAV from the ascending aorta to the LAD (n=2) or RCA (n=5). The diminutive LAD led to early graft loss due to size mismatch and poor runoff. HAV bypass to the dominant RCA (TTFM: 22 ± 7.7 mL/min) resulted in sustained graft patency for up to 6 months post-implantation. HAV explant histology revealed infiltration of multiple host cell populations with formation of a neoadventitial layer and evidence of luminal endothelization. HAV conduits retained structural integrity with no evidence of mechanical failure throughout the study. These results demonstrate that tissue-engineered HAVs may provide an off-the-shelf conduit for CABG.

Duke Scholars

Published In

Circulation Research

DOI

EISSN

1524-4571

ISSN

0009-7330

Publication Date

August 5, 2022

Volume

131

Issue

Suppl_1

Publisher

Ovid Technologies (Wolters Kluwer Health)

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Williams, A. R., Nellis, J., Wegermann, Z., McCartney, S., Podgoreanu, M. V., Mehta, S., … Kypson, A. P. (2022). Abstract P1017: Tissue Engineered Human Acellular Blood Vessels For Coronary Artery Bypass Grafting. In Circulation Research (Vol. 131). Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1161/res.131.suppl_1.p1017
Williams, Adam R., Joseph Nellis, Zachary Wegermann, Sharon McCartney, Mihai V. Podgoreanu, Sachin Mehta, Kyha D. Williams, et al. “Abstract P1017: Tissue Engineered Human Acellular Blood Vessels For Coronary Artery Bypass Grafting.” In Circulation Research, Vol. 131. Ovid Technologies (Wolters Kluwer Health), 2022. https://doi.org/10.1161/res.131.suppl_1.p1017.
Williams AR, Nellis J, Wegermann Z, McCartney S, Podgoreanu MV, Mehta S, et al. Abstract P1017: Tissue Engineered Human Acellular Blood Vessels For Coronary Artery Bypass Grafting. In: Circulation Research. Ovid Technologies (Wolters Kluwer Health); 2022.
Williams, Adam R., et al. “Abstract P1017: Tissue Engineered Human Acellular Blood Vessels For Coronary Artery Bypass Grafting.” Circulation Research, vol. 131, no. Suppl_1, Ovid Technologies (Wolters Kluwer Health), 2022. Crossref, doi:10.1161/res.131.suppl_1.p1017.
Williams AR, Nellis J, Wegermann Z, McCartney S, Podgoreanu MV, Mehta S, Williams KD, Daubert MA, Kirkton R, Nash K, Niklason L, Lawson JH, Kypson AP. Abstract P1017: Tissue Engineered Human Acellular Blood Vessels For Coronary Artery Bypass Grafting. Circulation Research. Ovid Technologies (Wolters Kluwer Health); 2022.

Published In

Circulation Research

DOI

EISSN

1524-4571

ISSN

0009-7330

Publication Date

August 5, 2022

Volume

131

Issue

Suppl_1

Publisher

Ovid Technologies (Wolters Kluwer Health)

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology