Post-Translational Modification of HMGB1 and Its Role in Immune Activation
Publication
, Journal Article
Ullal, AJ; Pisetsky, DS
April 29, 2009
High-mobility group box 1 (HMGB1) functions as an alarmin following release from activated or necrotic cells and mediates inflammation. Translocation and extracellular release ofHMGB1can also occur during apoptosis. This translocation ofHMGB1from the nucleus to the cytoplasm results from post-translational modifications similar to those affecting histones. Such post-translational modifications of HMGB1 could also have effects on gene expression following changes in its DNA-binding properties. Furthermore, modified HMGB1 in the extracellular environment displays immunological activity and could serve as a potential target for new therapy. © 2009 John Wiley & Sons Ltd.
Duke Scholars
Citation
APA
Chicago
ICMJE
MLA
NLM
Ullal, A. J., & Pisetsky, D. S. (2009). Post-Translational Modification of HMGB1 and Its Role in Immune Activation, 165–178. https://doi.org/10.1002/9780470743553.ch10
Ullal, A. J., and D. S. Pisetsky. “Post-Translational Modification of HMGB1 and Its Role in Immune Activation,” April 29, 2009, 165–78. https://doi.org/10.1002/9780470743553.ch10.
Ullal AJ, Pisetsky DS. Post-Translational Modification of HMGB1 and Its Role in Immune Activation. 2009 Apr 29;165–78.
Ullal, A. J., and D. S. Pisetsky. Post-Translational Modification of HMGB1 and Its Role in Immune Activation. Apr. 2009, pp. 165–78. Scopus, doi:10.1002/9780470743553.ch10.
Ullal AJ, Pisetsky DS. Post-Translational Modification of HMGB1 and Its Role in Immune Activation. 2009 Apr 29;165–178.