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Sonic hedgehog pathway

Publication ,  Journal Article
Omenetti, A; Diehl, AM
December 1, 2010

The Hedgehog (Hh) Pathway, originally identified in Drosophila, [1-4] is a highly conserved signaling pathway which orchestrates multiple, disparate aspects of embryogenesis, development and tissue remodeling in a wide spectrum of systems [5-8]. This is usually accomplished by autocrine/paracrine signaling and aims to control the size and localization of Hh-responsive cell populations in response to local/long distance signals [7, 9]. Hh pathway activation typically enhances the growth and viability of Hh-responsive cells, whereas abrogating Hh signal transduction usually triggers apoptosis in such cells, unless other locally available differentiating factors expedite cellular differentiation to a more mature phenotype that no longer requires Hh viability signals [5, 9]. Thus, up-/down-regulation of the Hh pathway provides a selective growth advantage for cell types that are capable of responding to Hh ligands, when compared to neighboring cells that lack Hh receptors. This leads to-expansion/contraction, respectively, of Hh-responsive cells, thereby, orchestrating the cellular composition of several tissues [5-7, 9]. © 2010 Springer-Verlag Berlin Heidelberg.

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Publication Date

December 1, 2010

Start / End Page

393 / 401
 

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Omenetti, A., & Diehl, A. M. (2010). Sonic hedgehog pathway, 393–401. https://doi.org/10.1007/978-3-642-00150-5_26
Omenetti, A., and A. M. Diehl. “Sonic hedgehog pathway,” December 1, 2010, 393–401. https://doi.org/10.1007/978-3-642-00150-5_26.
Omenetti A, Diehl AM. Sonic hedgehog pathway. 2010 Dec 1;393–401.
Omenetti, A., and A. M. Diehl. Sonic hedgehog pathway. Dec. 2010, pp. 393–401. Scopus, doi:10.1007/978-3-642-00150-5_26.
Omenetti A, Diehl AM. Sonic hedgehog pathway. 2010 Dec 1;393–401.

DOI

Publication Date

December 1, 2010

Start / End Page

393 / 401