Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Prognostic value of Rb-82 positron emission tomography myocardial perfusion imaging in coronary artery bypass patients.

Publication ,  Journal Article
Pen, A; Yam, Y; Chen, L; Dorbala, S; Di Carli, MF; Merhige, ME; Williams, BA; Veladar, E; Min, JK; Pencina, MJ; Berman, DS; Beanlands, RS ...
Published in: Eur Heart J Cardiovasc Imaging
July 2014

AIMS: We sought to determine the prognostic value of positron emission tomography (PET) myocardial perfusion imaging (MPI) in patients with prior coronary artery bypass graft (CABG) surgery. PET MPI has recently been shown to provide incremental risk stratification for patients with suspected coronary artery disease (CAD), but the prognostic utility of PET MPI in CABG patients has not been well studied. METHODS AND RESULTS: A multi-centre PET registry of 7061 patients who underwent Rb-82 PET MPI from four participating centres was screened. Nine hundred and fifty-three CABG patients were identified and their images were analysed. Outcomes of all-cause mortality and cardiac death were collected. With a mean follow-up of 2.4 ± 1.4 years, 128 (13.4%) all-cause deaths and 44 (4.6%) cardiac deaths were observed. Multivariable analyses, adjusted for clinical variables, demonstrated that the summed stress score (SSS) was a significant independent predictor of both all-cause mortality [HR: 1.60 (per 1 category increase in SSS); 95% CI: 1.34-1.92; P < 0.001] and cardiac death (HR: 1.80; 95% CI: 1.33, 2.44; P < 0.001). The receiver-operator characteristic (ROC) curves showed that the addition of SSS increased the area under the curve (AUC) from 0.645 to 0.693 (P = 0.014) for all-cause mortality, and from 0.612 to 0.704 (P = 0.027) for cardiac death. SSS also improved the net reclassification improvement (NRI) for all-cause mortality (category-free NRI = 0.422; 95% CI: 0.240-0.603; P < 0.001) and cardiac death (category-free NRI = 0.552; 95% CI: 0.268-0.836; P < 0.001). CONCLUSIONS: PET MPI provides independent and incremental prognostic value to clinical variables in predicting all-cause mortality and cardiac death in CABG patients.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Eur Heart J Cardiovasc Imaging

DOI

EISSN

2047-2412

Publication Date

July 2014

Volume

15

Issue

7

Start / End Page

787 / 792

Location

England

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Rubidium Radioisotopes
  • Risk Assessment
  • Retrospective Studies
  • Registries
  • ROC Curve
  • Proportional Hazards Models
  • Prognosis
  • Predictive Value of Tests
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pen, A., Yam, Y., Chen, L., Dorbala, S., Di Carli, M. F., Merhige, M. E., … Chow, B. J. W. (2014). Prognostic value of Rb-82 positron emission tomography myocardial perfusion imaging in coronary artery bypass patients. Eur Heart J Cardiovasc Imaging, 15(7), 787–792. https://doi.org/10.1093/ehjci/jet259
Pen, Ally, Yeung Yam, Li Chen, Sharmila Dorbala, Marcelo F. Di Carli, Michael E. Merhige, Brent A. Williams, et al. “Prognostic value of Rb-82 positron emission tomography myocardial perfusion imaging in coronary artery bypass patients.Eur Heart J Cardiovasc Imaging 15, no. 7 (July 2014): 787–92. https://doi.org/10.1093/ehjci/jet259.
Pen A, Yam Y, Chen L, Dorbala S, Di Carli MF, Merhige ME, et al. Prognostic value of Rb-82 positron emission tomography myocardial perfusion imaging in coronary artery bypass patients. Eur Heart J Cardiovasc Imaging. 2014 Jul;15(7):787–92.
Pen, Ally, et al. “Prognostic value of Rb-82 positron emission tomography myocardial perfusion imaging in coronary artery bypass patients.Eur Heart J Cardiovasc Imaging, vol. 15, no. 7, July 2014, pp. 787–92. Pubmed, doi:10.1093/ehjci/jet259.
Pen A, Yam Y, Chen L, Dorbala S, Di Carli MF, Merhige ME, Williams BA, Veladar E, Min JK, Pencina MJ, Berman DS, Beanlands RS, Shaw LJ, Chow BJW. Prognostic value of Rb-82 positron emission tomography myocardial perfusion imaging in coronary artery bypass patients. Eur Heart J Cardiovasc Imaging. 2014 Jul;15(7):787–792.
Journal cover image

Published In

Eur Heart J Cardiovasc Imaging

DOI

EISSN

2047-2412

Publication Date

July 2014

Volume

15

Issue

7

Start / End Page

787 / 792

Location

England

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Rubidium Radioisotopes
  • Risk Assessment
  • Retrospective Studies
  • Registries
  • ROC Curve
  • Proportional Hazards Models
  • Prognosis
  • Predictive Value of Tests