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Measuring long-lived 13C2 state lifetimes at natural abundance.

Publication ,  Journal Article
Claytor, K; Theis, T; Feng, Y; Warren, W
Published in: Journal of magnetic resonance (San Diego, Calif. : 1997)
February 2014

Long-lived disconnected eigenstates (for example, the singlet state in a system with two nearly equivalent carbons, or the singlet-singlet state in a system with two chemically equivalent carbons and two chemically equivalent hydrogens) hold the potential to drastically extend the lifetime of hyperpolarization in molecular tracers for in vivo magnetic resonance imaging (MRI). However, a first-principles calculation of the expected lifetime (and thus selection of potential imaging agents) is made very difficult because of the large variety of relevant intra- and intermolecular relaxation mechanisms. As a result, all previous measurements relied on costly and time consuming syntheses of (13)C labeled compounds. Here we show that it is possible to determine (13)C singlet state lifetimes by detecting the naturally abundant doubly-labeled species. This approach allows for rapid and low cost screening of potential molecular biomarkers bearing long-lived states.

Duke Scholars

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Published In

Journal of magnetic resonance (San Diego, Calif. : 1997)

DOI

EISSN

1096-0856

ISSN

1090-7807

Publication Date

February 2014

Volume

239

Start / End Page

81 / 86

Related Subject Headings

  • Solvents
  • Reproducibility of Results
  • Nuclear Magnetic Resonance, Biomolecular
  • Isotope Labeling
  • Half-Life
  • Electromagnetic Fields
  • Carbon Isotopes
  • Biophysics
  • Alkynes
  • Algorithms
 

Citation

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Claytor, K., Theis, T., Feng, Y., & Warren, W. (2014). Measuring long-lived 13C2 state lifetimes at natural abundance. Journal of Magnetic Resonance (San Diego, Calif. : 1997), 239, 81–86. https://doi.org/10.1016/j.jmr.2013.12.009
Claytor, Kevin, Thomas Theis, Yesu Feng, and Warren Warren. “Measuring long-lived 13C2 state lifetimes at natural abundance.Journal of Magnetic Resonance (San Diego, Calif. : 1997) 239 (February 2014): 81–86. https://doi.org/10.1016/j.jmr.2013.12.009.
Claytor K, Theis T, Feng Y, Warren W. Measuring long-lived 13C2 state lifetimes at natural abundance. Journal of magnetic resonance (San Diego, Calif : 1997). 2014 Feb;239:81–6.
Claytor, Kevin, et al. “Measuring long-lived 13C2 state lifetimes at natural abundance.Journal of Magnetic Resonance (San Diego, Calif. : 1997), vol. 239, Feb. 2014, pp. 81–86. Epmc, doi:10.1016/j.jmr.2013.12.009.
Claytor K, Theis T, Feng Y, Warren W. Measuring long-lived 13C2 state lifetimes at natural abundance. Journal of magnetic resonance (San Diego, Calif : 1997). 2014 Feb;239:81–86.
Journal cover image

Published In

Journal of magnetic resonance (San Diego, Calif. : 1997)

DOI

EISSN

1096-0856

ISSN

1090-7807

Publication Date

February 2014

Volume

239

Start / End Page

81 / 86

Related Subject Headings

  • Solvents
  • Reproducibility of Results
  • Nuclear Magnetic Resonance, Biomolecular
  • Isotope Labeling
  • Half-Life
  • Electromagnetic Fields
  • Carbon Isotopes
  • Biophysics
  • Alkynes
  • Algorithms