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Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET).

Publication ,  Journal Article
Kauffman, CA; Freifeld, AG; Andes, DR; Baddley, JW; Herwaldt, L; Walker, RC; Alexander, BD; Anaissie, EJ; Benedict, K; Ito, JI; Knapp, KM ...
Published in: Transpl Infect Dis
April 2014

BACKGROUND: Invasive fungal infections are a major cause of morbidity and mortality among solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, but few data have been reported on the epidemiology of endemic fungal infections in these populations. METHODS: Fifteen institutions belonging to the Transplant-Associated Infection Surveillance Network prospectively enrolled SOT and HCT recipients with histoplasmosis, blastomycosis, or coccidioidomycosis occurring between March 2001 and March 2006. RESULTS: A total of 70 patients (64 SOT recipients and 6 HCT recipients) had infection with an endemic mycosis, including 52 with histoplasmosis, 9 with blastomycosis, and 9 with coccidioidomycosis. The 12-month cumulative incidence rate among SOT recipients for histoplasmosis was 0.102%. Occurrence of infection was bimodal; 28 (40%) infections occurred in the first 6 months post transplantation, and 24 (34%) occurred between 2 and 11 years post transplantation. Three patients were documented to have acquired infection from the donor organ. Seven SOT recipients with histoplasmosis and 3 with coccidioidomycosis died (16%); no HCT recipient died. CONCLUSIONS: This 5-year multicenter prospective surveillance study found that endemic mycoses occur uncommonly in SOT and HCT recipients, and that the period at risk extends for years after transplantation.

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Published In

Transpl Infect Dis

DOI

EISSN

1399-3062

Publication Date

April 2014

Volume

16

Issue

2

Start / End Page

213 / 224

Location

Denmark

Related Subject Headings

  • Young Adult
  • United States
  • Time Factors
  • Surgery
  • Respiratory Tract Infections
  • Prospective Studies
  • Organ Transplantation
  • Middle Aged
  • Male
  • Itraconazole
 

Citation

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Kauffman, C. A., Freifeld, A. G., Andes, D. R., Baddley, J. W., Herwaldt, L., Walker, R. C., … Pappas, P. G. (2014). Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET). Transpl Infect Dis, 16(2), 213–224. https://doi.org/10.1111/tid.12186
Kauffman, C. A., A. G. Freifeld, D. R. Andes, J. W. Baddley, L. Herwaldt, R. C. Walker, B. D. Alexander, et al. “Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET).Transpl Infect Dis 16, no. 2 (April 2014): 213–24. https://doi.org/10.1111/tid.12186.
Kauffman CA, Freifeld AG, Andes DR, Baddley JW, Herwaldt L, Walker RC, et al. Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET). Transpl Infect Dis. 2014 Apr;16(2):213–24.
Kauffman, C. A., et al. “Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET).Transpl Infect Dis, vol. 16, no. 2, Apr. 2014, pp. 213–24. Pubmed, doi:10.1111/tid.12186.
Kauffman CA, Freifeld AG, Andes DR, Baddley JW, Herwaldt L, Walker RC, Alexander BD, Anaissie EJ, Benedict K, Ito JI, Knapp KM, Lyon GM, Marr KA, Morrison VA, Park BJ, Patterson TF, Schuster MG, Chiller TM, Pappas PG. Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET). Transpl Infect Dis. 2014 Apr;16(2):213–224.
Journal cover image

Published In

Transpl Infect Dis

DOI

EISSN

1399-3062

Publication Date

April 2014

Volume

16

Issue

2

Start / End Page

213 / 224

Location

Denmark

Related Subject Headings

  • Young Adult
  • United States
  • Time Factors
  • Surgery
  • Respiratory Tract Infections
  • Prospective Studies
  • Organ Transplantation
  • Middle Aged
  • Male
  • Itraconazole