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Controlled apoptosis by a thermally toggled nanoscale amplifier of cellular uptake.

Publication ,  Journal Article
MacEwan, SR; Chilkoti, A
Published in: Nano letters
January 2014

Internalization into cancer cells is a significant challenge in the delivery of many anticancer therapeutics. Drug carriers can address this challenge by facilitating cellular uptake of cytotoxic cargo in the tumor, while preventing cellular uptake in healthy tissues. Here we describe an extrinsically controlled drug carrier, a nanopeptifier, that amplifies cellular uptake by modulating the activity of cell-penetrating peptides with thermally toggled self-assembly of a genetically encoded polypeptide nanoparticle. When appended with a proapoptotic peptide, the nanopeptifier creates a cytotoxic switch, inducing apoptosis only in its self-assembled state. The nanopeptifier provides a new approach to tune the cellular uptake and activity of anticancer therapeutics by an extrinsic thermal trigger.

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Published In

Nano letters

DOI

EISSN

1530-6992

ISSN

1530-6984

Publication Date

January 2014

Volume

14

Issue

4

Start / End Page

2058 / 2064

Related Subject Headings

  • Temperature
  • Peptides
  • Neoplasms
  • Nanoscience & Nanotechnology
  • Molecular Sequence Data
  • Humans
  • Hela Cells
  • HeLa Cells
  • Drug Delivery Systems
  • Delayed-Action Preparations
 

Citation

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MacEwan, S. R., & Chilkoti, A. (2014). Controlled apoptosis by a thermally toggled nanoscale amplifier of cellular uptake. Nano Letters, 14(4), 2058–2064. https://doi.org/10.1021/nl5002313
MacEwan, Sarah R., and Ashutosh Chilkoti. “Controlled apoptosis by a thermally toggled nanoscale amplifier of cellular uptake.Nano Letters 14, no. 4 (January 2014): 2058–64. https://doi.org/10.1021/nl5002313.
MacEwan SR, Chilkoti A. Controlled apoptosis by a thermally toggled nanoscale amplifier of cellular uptake. Nano letters. 2014 Jan;14(4):2058–64.
MacEwan, Sarah R., and Ashutosh Chilkoti. “Controlled apoptosis by a thermally toggled nanoscale amplifier of cellular uptake.Nano Letters, vol. 14, no. 4, Jan. 2014, pp. 2058–64. Epmc, doi:10.1021/nl5002313.
MacEwan SR, Chilkoti A. Controlled apoptosis by a thermally toggled nanoscale amplifier of cellular uptake. Nano letters. 2014 Jan;14(4):2058–2064.
Journal cover image

Published In

Nano letters

DOI

EISSN

1530-6992

ISSN

1530-6984

Publication Date

January 2014

Volume

14

Issue

4

Start / End Page

2058 / 2064

Related Subject Headings

  • Temperature
  • Peptides
  • Neoplasms
  • Nanoscience & Nanotechnology
  • Molecular Sequence Data
  • Humans
  • Hela Cells
  • HeLa Cells
  • Drug Delivery Systems
  • Delayed-Action Preparations