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Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment.

Publication ,  Journal Article
Shin, JH; Gadde, KM; Østbye, T; Bray, GA
Published in: Diabetes Obes Metab
August 2014

We evaluated weight changes in obese patients at 6-months after they ended participation in a 12-month randomised controlled trial in which they received daily placebo, zonisamide 200 mg or zonisamide 400 mg, in addition to lifestyle counselling. Of the originally randomised 225 patients, 218 completed month-12 when study interventions were discontinued. For the 154 patients who returned for 6-month follow-up off-treatment, weight changes between month-12 and month-18 for placebo (n = 53), zonisamide 200 mg (n = 49) and zonisamide 400 mg groups (n = 52) were 0.5 kg [95% confidence interval (CI), -0.8 to 1.8; 0.7%], 1.5 kg (0.2-2.8; 1.6%; p = 0.26 vs. placebo) and 2.4 kg (1.1-3.7; 2.6%; p = 0.04 vs. placebo), respectively. Our results suggest that although zonisamide 400 mg daily for 12-months resulted in greater weight loss than with placebo, weight regain after discontinuation of interventions was greater in the zonisamide 400 mg group than placebo group.

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Published In

Diabetes Obes Metab

DOI

EISSN

1463-1326

Publication Date

August 2014

Volume

16

Issue

8

Start / End Page

766 / 768

Location

England

Related Subject Headings

  • Zonisamide
  • Weight Gain
  • Patient Education as Topic
  • Patient Compliance
  • Obesity
  • North Carolina
  • Middle Aged
  • Male
  • Life Style
  • Isoxazoles
 

Citation

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Shin, J. H., Gadde, K. M., Østbye, T., & Bray, G. A. (2014). Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment. Diabetes Obes Metab, 16(8), 766–768. https://doi.org/10.1111/dom.12275
Shin, J. H., K. M. Gadde, T. Østbye, and G. A. Bray. “Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment.Diabetes Obes Metab 16, no. 8 (August 2014): 766–68. https://doi.org/10.1111/dom.12275.
Shin JH, Gadde KM, Østbye T, Bray GA. Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment. Diabetes Obes Metab. 2014 Aug;16(8):766–8.
Shin, J. H., et al. “Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment.Diabetes Obes Metab, vol. 16, no. 8, Aug. 2014, pp. 766–68. Pubmed, doi:10.1111/dom.12275.
Shin JH, Gadde KM, Østbye T, Bray GA. Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment. Diabetes Obes Metab. 2014 Aug;16(8):766–768.
Journal cover image

Published In

Diabetes Obes Metab

DOI

EISSN

1463-1326

Publication Date

August 2014

Volume

16

Issue

8

Start / End Page

766 / 768

Location

England

Related Subject Headings

  • Zonisamide
  • Weight Gain
  • Patient Education as Topic
  • Patient Compliance
  • Obesity
  • North Carolina
  • Middle Aged
  • Male
  • Life Style
  • Isoxazoles