Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Application of new cholesterol guidelines to a population-based sample.

Publication ,  Journal Article
Pencina, MJ; Navar-Boggan, AM; D'Agostino, RB; Williams, K; Neely, B; Sniderman, AD; Peterson, ED
Published in: N Engl J Med
April 10, 2014

BACKGROUND: The 2013 guidelines of the American College of Cardiology and the American Heart Association (ACC-AHA) for the treatment of cholesterol expand the indications for statin therapy for the prevention of cardiovascular disease. METHODS: Using data from the National Health and Nutrition Examination Surveys of 2005 to 2010, we estimated the number, and summarized the risk-factor profile, of persons for whom statin therapy would be recommended (i.e., eligible persons) under the new ACC-AHA guidelines, as compared with the guidelines of the Third Adult Treatment Panel (ATP III) of the National Cholesterol Education Program, and extrapolated the results to a population of 115.4 million U.S. adults between the ages of 40 and 75 years. RESULTS: As compared with the ATP-III guidelines, the new guidelines would increase the number of U.S. adults receiving or eligible for statin therapy from 43.2 million (37.5%) to 56.0 million (48.6%). Most of this increase in numbers (10.4 million of 12.8 million) would occur among adults without cardiovascular disease. Among adults between the ages of 60 and 75 years without cardiovascular disease who are not receiving statin therapy, the percentage who would be eligible for such therapy would increase from 30.4% to 87.4% among men and from 21.2% to 53.6% among women. This effect would be driven largely by an increased number of adults who would be classified solely on the basis of their 10-year risk of a cardiovascular event. Those who would be newly eligible for statin therapy include more men than women and persons with a higher blood pressure but a markedly lower level of low-density lipoprotein cholesterol. As compared with the ATP-III guidelines, the new guidelines would recommend statin therapy for more adults who would be expected to have future cardiovascular events (higher sensitivity) but would also include many adults who would not have future events (lower specificity). CONCLUSIONS: The new ACC-AHA guidelines for the management of cholesterol would increase the number of adults who would be eligible for statin therapy by 12.8 million, with the increase seen mostly among older adults without cardiovascular disease. (Funded by the Duke Clinical Research Institute and others.).

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

N Engl J Med

DOI

EISSN

1533-4406

Publication Date

April 10, 2014

Volume

370

Issue

15

Start / End Page

1422 / 1431

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Practice Guidelines as Topic
  • Nutrition Surveys
  • Middle Aged
  • Male
  • Hypercholesterolemia
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • General & Internal Medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pencina, M. J., Navar-Boggan, A. M., D’Agostino, R. B., Williams, K., Neely, B., Sniderman, A. D., & Peterson, E. D. (2014). Application of new cholesterol guidelines to a population-based sample. N Engl J Med, 370(15), 1422–1431. https://doi.org/10.1056/NEJMoa1315665
Pencina, Michael J., Ann Marie Navar-Boggan, Ralph B. D’Agostino, Ken Williams, Benjamin Neely, Allan D. Sniderman, and Eric D. Peterson. “Application of new cholesterol guidelines to a population-based sample.N Engl J Med 370, no. 15 (April 10, 2014): 1422–31. https://doi.org/10.1056/NEJMoa1315665.
Pencina MJ, Navar-Boggan AM, D’Agostino RB, Williams K, Neely B, Sniderman AD, et al. Application of new cholesterol guidelines to a population-based sample. N Engl J Med. 2014 Apr 10;370(15):1422–31.
Pencina, Michael J., et al. “Application of new cholesterol guidelines to a population-based sample.N Engl J Med, vol. 370, no. 15, Apr. 2014, pp. 1422–31. Pubmed, doi:10.1056/NEJMoa1315665.
Pencina MJ, Navar-Boggan AM, D’Agostino RB, Williams K, Neely B, Sniderman AD, Peterson ED. Application of new cholesterol guidelines to a population-based sample. N Engl J Med. 2014 Apr 10;370(15):1422–1431.

Published In

N Engl J Med

DOI

EISSN

1533-4406

Publication Date

April 10, 2014

Volume

370

Issue

15

Start / End Page

1422 / 1431

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Practice Guidelines as Topic
  • Nutrition Surveys
  • Middle Aged
  • Male
  • Hypercholesterolemia
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • General & Internal Medicine