The study of the neuroprotective activity of the apolipoprotein e peptide mimetic Cog1410 in transgenic strains of Drosophila melanogaster
Publication
, Journal Article
Latypova, EM; Timoshenko, SI; Kislik, GA; Vitek, MP; Schwarzman, AL; Sarantseva, SV
Published in: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
January 1, 2014
The neuroprotective activity of peptide mimetic of apolipoprotein E (apoE) Cog1410, containing the amino acid sequence of the apoE receptor-binding domain, has been investigated in transgenic Drosophila melanogaster strains expressing human APP and beta-secretase genes. Expression of double transgenes caused neuropathological processes typical for Alzheimer's disease (AD): neurodegeneration, cognitive impairments, and amyloid deposition in the brain. It was shown that Cog1410 reduces neurodegeneration in the brain of transgenic flies and improves cognitive functions (odor recognition). These data suggest that Cog1410 is a potential neuroprotector that can be used in AD treatment. © 2014 Pleiades Publishing, Ltd.
Duke Scholars
Published In
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
DOI
EISSN
1990-7516
ISSN
1990-7508
Publication Date
January 1, 2014
Volume
8
Issue
1
Start / End Page
37 / 42
Citation
APA
Chicago
ICMJE
MLA
NLM
Latypova, E. M., Timoshenko, S. I., Kislik, G. A., Vitek, M. P., Schwarzman, A. L., & Sarantseva, S. V. (2014). The study of the neuroprotective activity of the apolipoprotein e peptide mimetic Cog1410 in transgenic strains of Drosophila melanogaster. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 8(1), 37–42. https://doi.org/10.1134/S1990750814010107
Latypova, E. M., S. I. Timoshenko, G. A. Kislik, M. P. Vitek, A. L. Schwarzman, and S. V. Sarantseva. “The study of the neuroprotective activity of the apolipoprotein e peptide mimetic Cog1410 in transgenic strains of Drosophila melanogaster.” Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 8, no. 1 (January 1, 2014): 37–42. https://doi.org/10.1134/S1990750814010107.
Latypova EM, Timoshenko SI, Kislik GA, Vitek MP, Schwarzman AL, Sarantseva SV. The study of the neuroprotective activity of the apolipoprotein e peptide mimetic Cog1410 in transgenic strains of Drosophila melanogaster. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2014 Jan 1;8(1):37–42.
Latypova, E. M., et al. “The study of the neuroprotective activity of the apolipoprotein e peptide mimetic Cog1410 in transgenic strains of Drosophila melanogaster.” Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, vol. 8, no. 1, Jan. 2014, pp. 37–42. Scopus, doi:10.1134/S1990750814010107.
Latypova EM, Timoshenko SI, Kislik GA, Vitek MP, Schwarzman AL, Sarantseva SV. The study of the neuroprotective activity of the apolipoprotein e peptide mimetic Cog1410 in transgenic strains of Drosophila melanogaster. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2014 Jan 1;8(1):37–42.
Published In
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
DOI
EISSN
1990-7516
ISSN
1990-7508
Publication Date
January 1, 2014
Volume
8
Issue
1
Start / End Page
37 / 42