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A randomized longitudinal factorial design to assess malaria vector control and disease management interventions in rural Tanzania.

Publication ,  Journal Article
Kramer, RA; Mboera, LEG; Senkoro, K; Lesser, A; Shayo, EH; Paul, CJ; Miranda, ML
Published in: International Journal of Environmental Research and Public Health
May 2014

The optimization of malaria control strategies is complicated by constraints posed by local health systems, infrastructure, limited resources, and the complex interactions between infection, disease, and treatment. The purpose of this paper is to describe the protocol of a randomized factorial study designed to address this research gap. This project will evaluate two malaria control interventions in Mvomero District, Tanzania: (1) a disease management strategy involving early detection and treatment by community health workers using rapid diagnostic technology; and (2) vector control through community-supported larviciding. Six study villages were assigned to each of four groups (control, early detection and treatment, larviciding, and early detection and treatment plus larviciding). The primary endpoint of interest was change in malaria infection prevalence across the intervention groups measured during annual longitudinal cross-sectional surveys. Recurring entomological surveying, household surveying, and focus group discussions will provide additional valuable insights. At baseline, 962 households across all 24 villages participated in a household survey; 2,884 members from 720 of these households participated in subsequent malariometric surveying. The study design will allow us to estimate the effect sizes of different intervention mixtures. Careful documentation of our study protocol may also serve other researchers designing field-based intervention trials.

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Published In

International Journal of Environmental Research and Public Health

DOI

EISSN

1660-4601

ISSN

1661-7827

Publication Date

May 2014

Volume

11

Issue

5

Start / End Page

5317 / 5332

Related Subject Headings

  • Toxicology
  • Tanzania
  • Socioeconomic Factors
  • Rural Population
  • Rural Health
  • Parasitemia
  • Malaria
  • Longitudinal Studies
  • Larva
  • Insecticides
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kramer, R. A., Mboera, L. E. G., Senkoro, K., Lesser, A., Shayo, E. H., Paul, C. J., & Miranda, M. L. (2014). A randomized longitudinal factorial design to assess malaria vector control and disease management interventions in rural Tanzania. International Journal of Environmental Research and Public Health, 11(5), 5317–5332. https://doi.org/10.3390/ijerph110505317
Kramer, Randall A., Leonard E. G. Mboera, Kesheni Senkoro, Adriane Lesser, Elizabeth H. Shayo, Christopher J. Paul, and Marie Lynn Miranda. “A randomized longitudinal factorial design to assess malaria vector control and disease management interventions in rural Tanzania.International Journal of Environmental Research and Public Health 11, no. 5 (May 2014): 5317–32. https://doi.org/10.3390/ijerph110505317.
Kramer RA, Mboera LEG, Senkoro K, Lesser A, Shayo EH, Paul CJ, et al. A randomized longitudinal factorial design to assess malaria vector control and disease management interventions in rural Tanzania. International Journal of Environmental Research and Public Health. 2014 May;11(5):5317–32.
Kramer, Randall A., et al. “A randomized longitudinal factorial design to assess malaria vector control and disease management interventions in rural Tanzania.International Journal of Environmental Research and Public Health, vol. 11, no. 5, May 2014, pp. 5317–32. Epmc, doi:10.3390/ijerph110505317.
Kramer RA, Mboera LEG, Senkoro K, Lesser A, Shayo EH, Paul CJ, Miranda ML. A randomized longitudinal factorial design to assess malaria vector control and disease management interventions in rural Tanzania. International Journal of Environmental Research and Public Health. 2014 May;11(5):5317–5332.

Published In

International Journal of Environmental Research and Public Health

DOI

EISSN

1660-4601

ISSN

1661-7827

Publication Date

May 2014

Volume

11

Issue

5

Start / End Page

5317 / 5332

Related Subject Headings

  • Toxicology
  • Tanzania
  • Socioeconomic Factors
  • Rural Population
  • Rural Health
  • Parasitemia
  • Malaria
  • Longitudinal Studies
  • Larva
  • Insecticides