Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne
Publication
, Journal Article
Jones, GB; Kilgore, MW; Pollenz, RS; Li, A; Mathews, JE; Wright, JM; Huber, RS; Tate, PL; Price, TL; Sticca, RP
Published in: Bioorganic and Medicinal Chemistry Letters
August 20, 1996
An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.
Duke Scholars
Published In
Bioorganic and Medicinal Chemistry Letters
DOI
ISSN
0960-894X
Publication Date
August 20, 1996
Volume
6
Issue
16
Start / End Page
1971 / 1976
Related Subject Headings
- Medicinal & Biomolecular Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 1115 Pharmacology and Pharmaceutical Sciences
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Jones, G. B., Kilgore, M. W., Pollenz, R. S., Li, A., Mathews, J. E., Wright, J. M., … Sticca, R. P. (1996). Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne. Bioorganic and Medicinal Chemistry Letters, 6(16), 1971–1976. https://doi.org/10.1016/0960-894X(96)00352-6
Jones, G. B., M. W. Kilgore, R. S. Pollenz, A. Li, J. E. Mathews, J. M. Wright, R. S. Huber, P. L. Tate, T. L. Price, and R. P. Sticca. “Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne.” Bioorganic and Medicinal Chemistry Letters 6, no. 16 (August 20, 1996): 1971–76. https://doi.org/10.1016/0960-894X(96)00352-6.
Jones GB, Kilgore MW, Pollenz RS, Li A, Mathews JE, Wright JM, et al. Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne. Bioorganic and Medicinal Chemistry Letters. 1996 Aug 20;6(16):1971–6.
Jones, G. B., et al. “Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne.” Bioorganic and Medicinal Chemistry Letters, vol. 6, no. 16, Aug. 1996, pp. 1971–76. Scopus, doi:10.1016/0960-894X(96)00352-6.
Jones GB, Kilgore MW, Pollenz RS, Li A, Mathews JE, Wright JM, Huber RS, Tate PL, Price TL, Sticca RP. Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne. Bioorganic and Medicinal Chemistry Letters. 1996 Aug 20;6(16):1971–1976.
Published In
Bioorganic and Medicinal Chemistry Letters
DOI
ISSN
0960-894X
Publication Date
August 20, 1996
Volume
6
Issue
16
Start / End Page
1971 / 1976
Related Subject Headings
- Medicinal & Biomolecular Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 1115 Pharmacology and Pharmaceutical Sciences
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry