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The role of the substantia nigra in posture control.

Publication ,  Journal Article
Barter, JW; Castro, S; Sukharnikova, T; Rossi, MA; Yin, HH
Published in: The European journal of neuroscience
May 2014

Disorders implicating the basal ganglia are often characterized by postural deficits, but little is known about the role of the basal ganglia in posture control. Using wireless multi-electrode recording, we measured single unit activity from GABAergic and dopaminergic neurons in the substantia nigra as unrestrained mice stood on an elevated platform while introducing continuous postural disturbances in the roll plane. We found two major types of neurons - those activated by tilt to the left side of the body and suppressed by tilt to the right side, and others activated by tilt to the right side and suppressed by tilt to the left side. Contrary to the prevailing view that the basal ganglia output from the substantia nigra pars reticulata either inhibits or disinhibits downstream structures in an all or none fashion, we showed that it continuously sends anti-phase signals to their downstream targets. We also demonstrated for the first time that nigrostriatal dopaminergic transmission is modulated by postural disturbances.

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Published In

The European journal of neuroscience

DOI

EISSN

1460-9568

ISSN

0953-816X

Publication Date

May 2014

Volume

39

Issue

9

Start / End Page

1465 / 1473

Related Subject Headings

  • Substantia Nigra
  • Postural Balance
  • Neurology & Neurosurgery
  • Mice, Inbred C57BL
  • Mice
  • Male
  • GABAergic Neurons
  • Dopaminergic Neurons
  • Animals
  • 5204 Cognitive and computational psychology
 

Citation

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Barter, J. W., Castro, S., Sukharnikova, T., Rossi, M. A., & Yin, H. H. (2014). The role of the substantia nigra in posture control. The European Journal of Neuroscience, 39(9), 1465–1473. https://doi.org/10.1111/ejn.12540
Barter, Joseph W., Stephen Castro, Tatyana Sukharnikova, Mark A. Rossi, and Henry H. Yin. “The role of the substantia nigra in posture control.The European Journal of Neuroscience 39, no. 9 (May 2014): 1465–73. https://doi.org/10.1111/ejn.12540.
Barter JW, Castro S, Sukharnikova T, Rossi MA, Yin HH. The role of the substantia nigra in posture control. The European journal of neuroscience. 2014 May;39(9):1465–73.
Barter, Joseph W., et al. “The role of the substantia nigra in posture control.The European Journal of Neuroscience, vol. 39, no. 9, May 2014, pp. 1465–73. Epmc, doi:10.1111/ejn.12540.
Barter JW, Castro S, Sukharnikova T, Rossi MA, Yin HH. The role of the substantia nigra in posture control. The European journal of neuroscience. 2014 May;39(9):1465–1473.
Journal cover image

Published In

The European journal of neuroscience

DOI

EISSN

1460-9568

ISSN

0953-816X

Publication Date

May 2014

Volume

39

Issue

9

Start / End Page

1465 / 1473

Related Subject Headings

  • Substantia Nigra
  • Postural Balance
  • Neurology & Neurosurgery
  • Mice, Inbred C57BL
  • Mice
  • Male
  • GABAergic Neurons
  • Dopaminergic Neurons
  • Animals
  • 5204 Cognitive and computational psychology