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An FGF-WNT gene regulatory network controls lung mesenchyme development.

Publication ,  Journal Article
Yin, Y; White, AC; Huh, S-H; Hilton, MJ; Kanazawa, H; Long, F; Ornitz, DM
Published in: Developmental biology
July 2008

Lung mesenchyme is a critical determinant of the shape and size of the lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung. Fibroblast growth factor 9 (FGF9) is a critical regulator of lung mesenchymal growth; however, upstream mechanisms that modulate the FGF mesenchymal signal and the downstream targets of mesenchymal FGF signaling are poorly understood. Here we have identified a robust regulatory network in which mesenchymal FGF signaling regulates beta-Catenin mediated WNT signaling in lung mesenchyme. By conditionally inactivating beta-Catenin in lung mesenchyme, we show that mesenchymal WNT-beta-Catenin signaling is essential for lung development and acts to regulate the cell cycle G1 to S transition and the FGF responsiveness of mesenchyme. Together, both FGF and WNT signaling pathways function to sustain mesenchymal growth and coordinate epithelial morphogenesis during the pseudoglandular stage of lung development.

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Published In

Developmental biology

DOI

EISSN

1095-564X

ISSN

0012-1606

Publication Date

July 2008

Volume

319

Issue

2

Start / End Page

426 / 436

Related Subject Headings

  • Wnt Proteins
  • RNA, Untranslated
  • RNA, Long Noncoding
  • Polymerase Chain Reaction
  • Mice, Knockout
  • Mice
  • Mesoderm
  • Male
  • Lung
  • Fibroblast Growth Factor 9
 

Citation

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Yin, Y., White, A. C., Huh, S.-H., Hilton, M. J., Kanazawa, H., Long, F., & Ornitz, D. M. (2008). An FGF-WNT gene regulatory network controls lung mesenchyme development. Developmental Biology, 319(2), 426–436. https://doi.org/10.1016/j.ydbio.2008.04.009
Yin, Yongjun, Andrew C. White, Sung-Ho Huh, Matthew J. Hilton, Hidemi Kanazawa, Fanxin Long, and David M. Ornitz. “An FGF-WNT gene regulatory network controls lung mesenchyme development.Developmental Biology 319, no. 2 (July 2008): 426–36. https://doi.org/10.1016/j.ydbio.2008.04.009.
Yin Y, White AC, Huh S-H, Hilton MJ, Kanazawa H, Long F, et al. An FGF-WNT gene regulatory network controls lung mesenchyme development. Developmental biology. 2008 Jul;319(2):426–36.
Yin, Yongjun, et al. “An FGF-WNT gene regulatory network controls lung mesenchyme development.Developmental Biology, vol. 319, no. 2, July 2008, pp. 426–36. Epmc, doi:10.1016/j.ydbio.2008.04.009.
Yin Y, White AC, Huh S-H, Hilton MJ, Kanazawa H, Long F, Ornitz DM. An FGF-WNT gene regulatory network controls lung mesenchyme development. Developmental biology. 2008 Jul;319(2):426–436.
Journal cover image

Published In

Developmental biology

DOI

EISSN

1095-564X

ISSN

0012-1606

Publication Date

July 2008

Volume

319

Issue

2

Start / End Page

426 / 436

Related Subject Headings

  • Wnt Proteins
  • RNA, Untranslated
  • RNA, Long Noncoding
  • Polymerase Chain Reaction
  • Mice, Knockout
  • Mice
  • Mesoderm
  • Male
  • Lung
  • Fibroblast Growth Factor 9