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Personalized antiplatelet therapy

Publication ,  Journal Article
Gurbel, PA; Rafeedheen, R; Tantry, US
Published in: Revista Espanola de Cardiologia
January 1, 2014
Published version (DOI)

It is well established that high on-treatment platelet reactivity to adenosine diphosphate during clopidogrel therapy is an independent risk factor for ischemic event occurrences in a postpercutaneous coronary intervention patients. However, the precise role of platelet function testing remains debated. Platelet function testing to ensure optimal platelet inhibition has been recommended by some authorities to improve outcomes in patients treated with clopidogrel. Recent prospective, randomized trials of personalized antiplatelet therapy have failed to demonstrate a benefit of platelet function testing in improving outcomes. In this review article, we discuss the mechanisms responsible for clopidogrel nonreponsiveness, recent trials of platelet function testing, and other new developments in the field of personalized antiplatelet therapy. © 2013 Sociedad Espanola de Cardiologa.

Duke Scholars

Paul Alfred Gurbel
Author Paul Alfred Gurbel Medicine, Clinical Pharmacology

Published In

Revista Espanola de Cardiologia

DOI

10.1016/j.recesp.2014.01.013

EISSN

1579-2242

ISSN

0300-8932

Publication Date

January 1, 2014

Volume

67

Issue

6

Start / End Page

480 / 487

Related Subject Headings

  • Cardiovascular System & Hematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
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ICMJE
MLA
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Gurbel, P. A., Rafeedheen, R., & Tantry, U. S. (2014). Personalized antiplatelet therapy. Revista Espanola de Cardiologia, 67(6), 480–487. https://doi.org/10.1016/j.recesp.2014.01.013
Gurbel, P. A., R. Rafeedheen, and U. S. Tantry. “Personalized antiplatelet therapy.” Revista Espanola de Cardiologia 67, no. 6 (January 1, 2014): 480–87. https://doi.org/10.1016/j.recesp.2014.01.013.
Gurbel PA, Rafeedheen R, Tantry US. Personalized antiplatelet therapy. Revista Espanola de Cardiologia. 2014 Jan 1;67(6):480–7.
Gurbel, P. A., et al. “Personalized antiplatelet therapy.” Revista Espanola de Cardiologia, vol. 67, no. 6, Jan. 2014, pp. 480–87. Scopus, doi:10.1016/j.recesp.2014.01.013.
Gurbel PA, Rafeedheen R, Tantry US. Personalized antiplatelet therapy. Revista Espanola de Cardiologia. 2014 Jan 1;67(6):480–487.

Published In

Revista Espanola de Cardiologia

DOI

10.1016/j.recesp.2014.01.013

EISSN

1579-2242

ISSN

0300-8932

Publication Date

January 1, 2014

Volume

67

Issue

6

Start / End Page

480 / 487

Related Subject Headings

  • Cardiovascular System & Hematology
  • 1102 Cardiorespiratory Medicine and Haematology