Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Gaining the Patient Reported Outcomes Measurement Information System (PROMIS) perspective in chronic kidney disease: a Midwest Pediatric Nephrology Consortium study.

Publication ,  Journal Article
Selewski, DT; Massengill, SF; Troost, JP; Wickman, L; Messer, KL; Herreshoff, E; Bowers, C; Ferris, ME; Mahan, JD; Greenbaum, LA; MacHardy, J ...
Published in: Pediatr Nephrol
December 2014

BACKGROUND AND OBJECTIVES: Chronic kidney disease is a persistent chronic health condition commonly seen in pediatric nephrology programs. Our study aims to evaluate the sensitivity of the Patient Reported Outcomes Measurement Information System (PROMIS) pediatric instrument to indicators of disease severity and activity in pediatric chronic kidney disease. METHODS: This cross sectional study included 233 children 8-17 years old, with chronic kidney disease from 16 participating institutions in North America. Disease activity indicators, including hospitalization in the previous 6 months, edema, and number of medications consumed daily, as well as disease severity indicators of kidney function and coexisting medical conditions were captured. PROMIS domains, including depression, anxiety, social-peer relationships, pain interference, fatigue, mobility, and upper extremity function, were administered via web-based questionnaires. Absolute effect sizes (AES) were generated to demonstrate the impact of disease on domain scores. Four children were excluded because of missing glomerular filtration rate (GFR) estimations. RESULTS: Of the 229 children included in the final analysis, 221 completed the entire PROMIS questionnaire. Unadjusted PROMIS domains were responsive to chronic kidney disease activity indicators and number of coexisting conditions. PROMIS domain scores were worse in the presence of recent hospitalizations (depression AES 0.33, anxiety AES 0.42, pain interference AES 0.46, fatigue AES 0.50, mobility AES 0.49), edema (depression AES 0.50, anxiety AES 0.60, pain interference AES 0.77, mobility AES 0.54) and coexisting medical conditions (social peer-relationships AES 0.66, fatigue AES 0.83, mobility AES 0.60, upper extremity function AES 0.48). CONCLUSIONS: The PROMIS pediatric domains of depression, anxiety, social-peer relationships, pain interference, and mobility were sensitive to the clinical status of children with chronic kidney disease in this multi-center cross sectional study. We demonstrated that a number of important clinical characteristics including recent history of hospitalization and edema, affected patient perceptions of depression, anxiety, pain interference, fatigue and mobility. The PROMIS instruments provide a potentially valuable tool to study the impact of chronic kidney disease. Additional studies will be required to assess responsiveness in PROMIS score with changes in disease status over time.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Pediatr Nephrol

DOI

EISSN

1432-198X

Publication Date

December 2014

Volume

29

Issue

12

Start / End Page

2347 / 2356

Location

Germany

Related Subject Headings

  • Urology & Nephrology
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Self Report
  • Renal Insufficiency, Chronic
  • Quality of Life
  • Patient Outcome Assessment
  • Nephrology
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Selewski, D. T., Massengill, S. F., Troost, J. P., Wickman, L., Messer, K. L., Herreshoff, E., … Gipson, D. S. (2014). Gaining the Patient Reported Outcomes Measurement Information System (PROMIS) perspective in chronic kidney disease: a Midwest Pediatric Nephrology Consortium study. Pediatr Nephrol, 29(12), 2347–2356. https://doi.org/10.1007/s00467-014-2858-8
Selewski, David T., Susan F. Massengill, Jonathan P. Troost, Larysa Wickman, Kassandra L. Messer, Emily Herreshoff, Corinna Bowers, et al. “Gaining the Patient Reported Outcomes Measurement Information System (PROMIS) perspective in chronic kidney disease: a Midwest Pediatric Nephrology Consortium study.Pediatr Nephrol 29, no. 12 (December 2014): 2347–56. https://doi.org/10.1007/s00467-014-2858-8.
Selewski DT, Massengill SF, Troost JP, Wickman L, Messer KL, Herreshoff E, et al. Gaining the Patient Reported Outcomes Measurement Information System (PROMIS) perspective in chronic kidney disease: a Midwest Pediatric Nephrology Consortium study. Pediatr Nephrol. 2014 Dec;29(12):2347–56.
Selewski, David T., et al. “Gaining the Patient Reported Outcomes Measurement Information System (PROMIS) perspective in chronic kidney disease: a Midwest Pediatric Nephrology Consortium study.Pediatr Nephrol, vol. 29, no. 12, Dec. 2014, pp. 2347–56. Pubmed, doi:10.1007/s00467-014-2858-8.
Selewski DT, Massengill SF, Troost JP, Wickman L, Messer KL, Herreshoff E, Bowers C, Ferris ME, Mahan JD, Greenbaum LA, MacHardy J, Kapur G, Chand DH, Goebel J, Barletta GM, Geary D, Kershaw DB, Pan CG, Gbadegesin R, Hidalgo G, Lane JC, Leiser JD, Song PX, Thissen D, Liu Y, Gross HE, DeWalt DA, Gipson DS. Gaining the Patient Reported Outcomes Measurement Information System (PROMIS) perspective in chronic kidney disease: a Midwest Pediatric Nephrology Consortium study. Pediatr Nephrol. 2014 Dec;29(12):2347–2356.
Journal cover image

Published In

Pediatr Nephrol

DOI

EISSN

1432-198X

Publication Date

December 2014

Volume

29

Issue

12

Start / End Page

2347 / 2356

Location

Germany

Related Subject Headings

  • Urology & Nephrology
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Self Report
  • Renal Insufficiency, Chronic
  • Quality of Life
  • Patient Outcome Assessment
  • Nephrology
  • Male
  • Humans