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Co-opting biology to deliver drugs.

Publication ,  Journal Article
Yousefpour, P; Chilkoti, A
Published in: Biotechnology and bioengineering
September 2014

The goal of drug delivery is to improve the safety and therapeutic efficacy of drugs. This review focuses on delivery platforms that are either derived from endogenous pathways, long-circulating biomolecules and cells or that piggyback onto long-circulating biomolecules and cells. The first class of such platforms is protein-based delivery systems--albumin, transferrin, and fusion to the Fc domain of antibodies--that have a long-circulation half-life and are designed to transport different molecules. The second class is lipid-based delivery systems-lipoproteins and exosomes-that are naturally occurring circulating lipid particles. The third class is cell-based delivery systems--erythrocytes, macrophages, and platelets--that have evolved, for reasons central to their function, to exhibit a long life-time in the body. The last class is small molecule-based delivery systems that include folic acid. This article reviews the biology of these systems, their application in drug delivery, and the promises and limitations of these endogenous systems for drug delivery.

Duke Scholars

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Published In

Biotechnology and bioengineering

DOI

EISSN

1097-0290

ISSN

0006-3592

Publication Date

September 2014

Volume

111

Issue

9

Start / End Page

1699 / 1716

Related Subject Headings

  • Technology, Pharmaceutical
  • Pharmaceutical Preparations
  • Drug Delivery Systems
  • Biotechnology
  • Biotechnology
 

Citation

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Yousefpour, P., & Chilkoti, A. (2014). Co-opting biology to deliver drugs. Biotechnology and Bioengineering, 111(9), 1699–1716. https://doi.org/10.1002/bit.25307
Yousefpour, Parisa, and Ashutosh Chilkoti. “Co-opting biology to deliver drugs.Biotechnology and Bioengineering 111, no. 9 (September 2014): 1699–1716. https://doi.org/10.1002/bit.25307.
Yousefpour P, Chilkoti A. Co-opting biology to deliver drugs. Biotechnology and bioengineering. 2014 Sep;111(9):1699–716.
Yousefpour, Parisa, and Ashutosh Chilkoti. “Co-opting biology to deliver drugs.Biotechnology and Bioengineering, vol. 111, no. 9, Sept. 2014, pp. 1699–716. Epmc, doi:10.1002/bit.25307.
Yousefpour P, Chilkoti A. Co-opting biology to deliver drugs. Biotechnology and bioengineering. 2014 Sep;111(9):1699–1716.
Journal cover image

Published In

Biotechnology and bioengineering

DOI

EISSN

1097-0290

ISSN

0006-3592

Publication Date

September 2014

Volume

111

Issue

9

Start / End Page

1699 / 1716

Related Subject Headings

  • Technology, Pharmaceutical
  • Pharmaceutical Preparations
  • Drug Delivery Systems
  • Biotechnology
  • Biotechnology