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The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study.

Publication ,  Journal Article
Pisetsky, DS; Trace, SE; Brownley, KA; Hamer, RM; Zucker, NL; Roux-Lombard, P; Dayer, J-M; Bulik, CM
Published in: Cytokine
September 2014

Anorexia nervosa (AN) is a serious, potentially life-threatening disorder characterized by severe weight loss, dysregulated eating, and often excessive exercise. While psychiatric illnesses such as depression are associated with increased levels of pro-inflammatory mediators, evidence for such disturbances in patients with AN has been less clear. In an exploratory study of possible disturbances in immune responses in AN, we assayed a panel of cytokines and chemokines in the blood of patients undergoing inpatient treatment, testing the hypothesis that metabolic disturbances in this disease would lead to a pattern of immune disturbances distinct from that of other psychiatric diseases. For this purpose, we evaluated patients by the Beck Depression Inventory-II (BDI-II) and the Eating Disorders Examination-Questionnaire and assessed cytokines and chemokines by enzyme-linked immunosorbent assays. Patients reported a moderate level of depression (mean BDI-II = 22.6) but exhibited few immunologic abnormalities of the kind associated with major depressive disorder [e.g., increased interleukin (IL)-6]; RANTES showed the most frequent elevations and was increased in 4 of the patients studied. Together, these findings suggest that features of AN such as loss of adipose tissue and excessive exercise may attenuate cytokine production and thus modulate the experience of illness that impacts on core features of disease.

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Published In

Cytokine

DOI

EISSN

1096-0023

Publication Date

September 2014

Volume

69

Issue

1

Start / End Page

110 / 115

Location

England

Related Subject Headings

  • Young Adult
  • Weight Loss
  • Surveys and Questionnaires
  • Psychiatric Status Rating Scales
  • Pilot Projects
  • Middle Aged
  • Interleukin-6
  • Immunology
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Pisetsky, D. S., Trace, S. E., Brownley, K. A., Hamer, R. M., Zucker, N. L., Roux-Lombard, P., … Bulik, C. M. (2014). The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study. Cytokine, 69(1), 110–115. https://doi.org/10.1016/j.cyto.2014.05.018
Pisetsky, D. S., S. E. Trace, K. A. Brownley, R. M. Hamer, N. L. Zucker, P. Roux-Lombard, J. -. M. Dayer, and C. M. Bulik. “The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study.Cytokine 69, no. 1 (September 2014): 110–15. https://doi.org/10.1016/j.cyto.2014.05.018.
Pisetsky DS, Trace SE, Brownley KA, Hamer RM, Zucker NL, Roux-Lombard P, et al. The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study. Cytokine. 2014 Sep;69(1):110–5.
Pisetsky, D. S., et al. “The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study.Cytokine, vol. 69, no. 1, Sept. 2014, pp. 110–15. Pubmed, doi:10.1016/j.cyto.2014.05.018.
Pisetsky DS, Trace SE, Brownley KA, Hamer RM, Zucker NL, Roux-Lombard P, Dayer J-M, Bulik CM. The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study. Cytokine. 2014 Sep;69(1):110–115.

Published In

Cytokine

DOI

EISSN

1096-0023

Publication Date

September 2014

Volume

69

Issue

1

Start / End Page

110 / 115

Location

England

Related Subject Headings

  • Young Adult
  • Weight Loss
  • Surveys and Questionnaires
  • Psychiatric Status Rating Scales
  • Pilot Projects
  • Middle Aged
  • Interleukin-6
  • Immunology
  • Humans
  • Female