Skip to main content
Journal cover image

Assessment of the sensitivity and specificity of tissue-specific-based and anatomical-based optical biomarkers for rapid detection of human head and neck squamous cell carcinoma.

Publication ,  Journal Article
Hu, F; Vishwanath, K; Beumer, HW; Puscas, L; Afshari, HR; Esclamado, RM; Scher, R; Fisher, S; Lo, J; Mulvey, C; Ramanujam, N; Lee, WT
Published in: Oral Oncol
September 2014

OBJECTIVES: We propose the use of morphological optical biomarkers for rapid detection of human head and neck squamous cell carcinoma (HNSCC) by leveraging the underlying tissue characteristics in aerodigestive tracts. MATERIALS AND METHODS: Diffuse reflectance spectra were obtained from malignant and contra-lateral normal tissues of 57 patients undergoing panendoscopy and biopsy. Oxygen saturation, total hemoglobin concentration, and the reduced scattering coefficient were extracted. Differences in malignant and normal tissues were examined based on two different groupings: anatomical site and morphological tissue type. RESULTS AND CONCLUSIONS: Measurements were acquired from 252 sites, of which 51 were pathologically classified as SCC. Optical biomarkers exhibited statistical differences between malignant and normal samples. Contrast was enhanced when parsing tissues by morphological classification rather than anatomical subtype for unpaired comparisons. Corresponding linear discriminant models using multiple optical biomarkers showed improved predictive ability when accounting for morphological classification, particularly in node-positive lesions. The false-positive rate was retrospectively found to decrease by 34.2% in morphologically- vs. anatomically-derived predictive models. In glottic tissue, the surgeon exhibited a false-positive rate of 45.7% while the device showed a lower false-positive rate of 12.4%. Additionally, comparisons of optical parameters were made to further understand the physiology of tumor staging and potential causes of high surgeon false-positive rates. Optical spectroscopy is a user-friendly, non-invasive tool capable of providing quantitative information to discriminate malignant from normal head and neck tissues. Predictive models demonstrated promising results for real-time diagnostics. Furthermore, the strategy described appears to be well suited to reduce the clinical false-positive rate.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Oral Oncol

DOI

EISSN

1879-0593

Publication Date

September 2014

Volume

50

Issue

9

Start / End Page

848 / 856

Location

England

Related Subject Headings

  • Spectrum Analysis
  • Sensitivity and Specificity
  • Oncology & Carcinogenesis
  • Humans
  • Head and Neck Neoplasms
  • Dentistry
  • Carcinoma, Squamous Cell
  • Biomarkers, Tumor
  • 3211 Oncology and carcinogenesis
  • 3203 Dentistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hu, F., Vishwanath, K., Beumer, H. W., Puscas, L., Afshari, H. R., Esclamado, R. M., … Lee, W. T. (2014). Assessment of the sensitivity and specificity of tissue-specific-based and anatomical-based optical biomarkers for rapid detection of human head and neck squamous cell carcinoma. Oral Oncol, 50(9), 848–856. https://doi.org/10.1016/j.oraloncology.2014.06.015
Hu, Fangyao, Karthik Vishwanath, H Wolfgang Beumer, Liana Puscas, Hamid R. Afshari, Ramon M. Esclamado, Richard Scher, et al. “Assessment of the sensitivity and specificity of tissue-specific-based and anatomical-based optical biomarkers for rapid detection of human head and neck squamous cell carcinoma.Oral Oncol 50, no. 9 (September 2014): 848–56. https://doi.org/10.1016/j.oraloncology.2014.06.015.
Hu, Fangyao, et al. “Assessment of the sensitivity and specificity of tissue-specific-based and anatomical-based optical biomarkers for rapid detection of human head and neck squamous cell carcinoma.Oral Oncol, vol. 50, no. 9, Sept. 2014, pp. 848–56. Pubmed, doi:10.1016/j.oraloncology.2014.06.015.
Hu F, Vishwanath K, Beumer HW, Puscas L, Afshari HR, Esclamado RM, Scher R, Fisher S, Lo J, Mulvey C, Ramanujam N, Lee WT. Assessment of the sensitivity and specificity of tissue-specific-based and anatomical-based optical biomarkers for rapid detection of human head and neck squamous cell carcinoma. Oral Oncol. 2014 Sep;50(9):848–856.
Journal cover image

Published In

Oral Oncol

DOI

EISSN

1879-0593

Publication Date

September 2014

Volume

50

Issue

9

Start / End Page

848 / 856

Location

England

Related Subject Headings

  • Spectrum Analysis
  • Sensitivity and Specificity
  • Oncology & Carcinogenesis
  • Humans
  • Head and Neck Neoplasms
  • Dentistry
  • Carcinoma, Squamous Cell
  • Biomarkers, Tumor
  • 3211 Oncology and carcinogenesis
  • 3203 Dentistry