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Spatial heterogeneity of restitution properties and the onset of alternans.

Publication ,  Journal Article
Dobrovolny, HM; Berger, CM; Brown, NH; Neu, WK; Gauthier, DJ
Published in: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
December 1, 2009

Traditionally, it was believed that cardiac rhythm stability was governed by the slope of the restitution curve (RC), which relates the duration of an action potential to the preceding diastolic interval. However, a single RC does not exist; rate-dependence leads to multiple distinct RCs. We measure spatial differences in the steady-state action potential duration (APD), as well as in three different RCs: the S1-S2 (SRC), constant-basic-cycle-length (BRC), and dynamic (DRC), and correlate these differences with the tissue's propensity to develop alternans. The results show that spatial differences in APD, SRC slope, and DRC slope are correlated with the tissue's propensity to exhibit alternans. These results may lead to a new diagnostic approach to identifying patients with vulnerability to arrhythmias, which will involve pacing at slow rates and analyzing spatial differences in restitution properties.

Duke Scholars

Published In

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

ISSN

1557-170X

Publication Date

December 1, 2009

Start / End Page

4186 / 4189
 

Citation

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Dobrovolny, H. M., Berger, C. M., Brown, N. H., Neu, W. K., & Gauthier, D. J. (2009). Spatial heterogeneity of restitution properties and the onset of alternans. Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 4186–4189.
Dobrovolny, H. M., C. M. Berger, N. H. Brown, W. K. Neu, and D. J. Gauthier. “Spatial heterogeneity of restitution properties and the onset of alternans.Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, December 1, 2009, 4186–89.
Dobrovolny HM, Berger CM, Brown NH, Neu WK, Gauthier DJ. Spatial heterogeneity of restitution properties and the onset of alternans. Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2009 Dec 1;4186–9.
Dobrovolny, H. M., et al. “Spatial heterogeneity of restitution properties and the onset of alternans.Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, Dec. 2009, pp. 4186–89.
Dobrovolny HM, Berger CM, Brown NH, Neu WK, Gauthier DJ. Spatial heterogeneity of restitution properties and the onset of alternans. Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2009 Dec 1;4186–4189.

Published In

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

ISSN

1557-170X

Publication Date

December 1, 2009

Start / End Page

4186 / 4189