Skip to main content

Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice.

Publication ,  Journal Article
Belle, I; Mahlios, J; McKenzie, A; Zhuang, Y
Published in: Cytokine
October 2014

Elevated levels of the cytokine IL-13 has been found to be associated with autoimmune diseases, including Sjögren's Syndrome. However, whether IL-13 plays a causative role in disease development is not known and cannot be easily studied in humans. Our previous work has shown that levels of IL-13 are elevated in Id3 knockout mice, which has been established as a model for primary Sjögren's Syndrome. Here, we utilized an IL-13 reporter to determine the source of the elevated IL-13 levels observed in Id3 knockout mice and assess its contribution to SS pathology. Our results indicate that T cells, notably CD4 and γδ T cells, in Id3 knockout mice acquire IL-13 competency at an elevated rate well before disease symptoms become apparent. We also show that T cells developing early in life are more predisposed to produce IL-13. Finally, analysis of Id3 and IL-13 double deficient mice demonstrated that IL-13 plays an essential role in the deterioration of gland function. Our study provides crucial genetic evidence that enhanced IL-13 production by T cells can play a causative role in the exocrinopathy observed in Id3 knockout mice.

Duke Scholars

Published In

Cytokine

DOI

EISSN

1096-0023

Publication Date

October 2014

Volume

69

Issue

2

Start / End Page

226 / 233

Location

England

Related Subject Headings

  • Thymocytes
  • T-Lymphocytes
  • Salivary Glands
  • Receptors, Antigen, T-Cell, gamma-delta
  • Mice, Knockout
  • Interleukin-13
  • Inhibitor of Differentiation Proteins
  • Immunology
  • Exocrine Glands
  • Animals, Newborn
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Belle, I., Mahlios, J., McKenzie, A., & Zhuang, Y. (2014). Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice. Cytokine, 69(2), 226–233. https://doi.org/10.1016/j.cyto.2014.06.009
Belle, Ian, Josh Mahlios, Andrew McKenzie, and Yuan Zhuang. “Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice.Cytokine 69, no. 2 (October 2014): 226–33. https://doi.org/10.1016/j.cyto.2014.06.009.
Belle I, Mahlios J, McKenzie A, Zhuang Y. Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice. Cytokine. 2014 Oct;69(2):226–33.
Belle, Ian, et al. “Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice.Cytokine, vol. 69, no. 2, Oct. 2014, pp. 226–33. Pubmed, doi:10.1016/j.cyto.2014.06.009.
Belle I, Mahlios J, McKenzie A, Zhuang Y. Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice. Cytokine. 2014 Oct;69(2):226–233.

Published In

Cytokine

DOI

EISSN

1096-0023

Publication Date

October 2014

Volume

69

Issue

2

Start / End Page

226 / 233

Location

England

Related Subject Headings

  • Thymocytes
  • T-Lymphocytes
  • Salivary Glands
  • Receptors, Antigen, T-Cell, gamma-delta
  • Mice, Knockout
  • Interleukin-13
  • Inhibitor of Differentiation Proteins
  • Immunology
  • Exocrine Glands
  • Animals, Newborn