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Surgical management of complex rectourethral fistulas in irradiated and nonirradiated patients.

Publication ,  Journal Article
Hanna, JM; Turley, R; Castleberry, A; Hopkins, T; Peterson, AC; Mantyh, C; Migaly, J
Published in: Dis Colon Rectum
September 2014

BACKGROUND: Rectourethral fistulas are an uncommon, yet devastating occurrence after treatment for prostate cancer or trauma, and their surgical management has historically been nonstandardized. Anecdotally, irradiated rectourethral fistulas portend a worse prognosis. OBJECTIVE: To review outcomes after surgical treatment of rectourethral fistulas in radiated and nonirradiated patients to construct a logical surgical algorithm. DESIGN AND SETTING: A retrospective review was undertaken of all patients presenting to Duke University with the diagnosis of rectourethral fistula from 1996 to 2012. PATIENTS: Thirty-seven patients presented with and were treated for rectourethral fistulas: 21 received radiation, and a rectourethral fistula from trauma or iatrogenic injury developed in 16. MAIN OUTCOME MEASURES: The groups were compared regarding their functional outcomes, including healing, time to healing, continence, and recurrence. RESULTS: There were no significant differences in patient characteristics between groups. Patients who had irradiated rectourethral fistulas had a significantly higher rate of passage of urine through the rectum and wound infections, a higher rate of crystalloid infusion and blood transfusion requirements, and a longer time to ostomy reversal than nonirradiated patients. Patients who had irradiated rectourethral fistulas underwent more complex operative repairs, including gracilis interposition flaps (38%) and pelvic exenterations (19%), whereas nonirradiated patients most commonly underwent a York-Mason repair (50%). There were no statistically significant differences in rectourethral fistula healing or in postoperative and functional outcomes. Only 55% of irradiated patients had their ostomy reversed versus 91% in the nonirradiated group. LIMITATIONS: This study was limited by the small sample size and the retrospective nature of the review. CONCLUSIONS: Repair of rectourethral fistulas caused by radiation has a significantly higher wound infection rate and median time to healing, and lower overall stomal reversal rate than nonradiation-induced rectourethral fistulas. Patients who had irradiated rectourethral fistulas required significantly more complex operations, likely contributing to the higher morbidity, mortality, and lower fistula closure rate. We propose an algorithm for approaching rectourethral fistulas based on etiology.

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Published In

Dis Colon Rectum

DOI

EISSN

1530-0358

Publication Date

September 2014

Volume

57

Issue

9

Start / End Page

1105 / 1112

Location

United States

Related Subject Headings

  • Urinary Fistula
  • Urethral Diseases
  • Treatment Outcome
  • Surgical Flaps
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Rectal Fistula
  • Prostatic Neoplasms
  • Middle Aged
 

Citation

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Hanna, J. M., Turley, R., Castleberry, A., Hopkins, T., Peterson, A. C., Mantyh, C., & Migaly, J. (2014). Surgical management of complex rectourethral fistulas in irradiated and nonirradiated patients. Dis Colon Rectum, 57(9), 1105–1112. https://doi.org/10.1097/DCR.0000000000000175
Hanna, Jennifer M., Ryan Turley, Anthony Castleberry, Thomas Hopkins, Andrew C. Peterson, Christopher Mantyh, and John Migaly. “Surgical management of complex rectourethral fistulas in irradiated and nonirradiated patients.Dis Colon Rectum 57, no. 9 (September 2014): 1105–12. https://doi.org/10.1097/DCR.0000000000000175.
Hanna JM, Turley R, Castleberry A, Hopkins T, Peterson AC, Mantyh C, et al. Surgical management of complex rectourethral fistulas in irradiated and nonirradiated patients. Dis Colon Rectum. 2014 Sep;57(9):1105–12.
Hanna, Jennifer M., et al. “Surgical management of complex rectourethral fistulas in irradiated and nonirradiated patients.Dis Colon Rectum, vol. 57, no. 9, Sept. 2014, pp. 1105–12. Pubmed, doi:10.1097/DCR.0000000000000175.
Hanna JM, Turley R, Castleberry A, Hopkins T, Peterson AC, Mantyh C, Migaly J. Surgical management of complex rectourethral fistulas in irradiated and nonirradiated patients. Dis Colon Rectum. 2014 Sep;57(9):1105–1112.

Published In

Dis Colon Rectum

DOI

EISSN

1530-0358

Publication Date

September 2014

Volume

57

Issue

9

Start / End Page

1105 / 1112

Location

United States

Related Subject Headings

  • Urinary Fistula
  • Urethral Diseases
  • Treatment Outcome
  • Surgical Flaps
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Rectal Fistula
  • Prostatic Neoplasms
  • Middle Aged