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Myelodysplastic syndromes in the United States: an update for clinicians.

Publication ,  Journal Article
Troy, JD; Atallah, E; Geyer, JT; Saber, W
Published in: Ann Med
August 2014

Myelodysplastic syndromes (MDS) are heterogeneous malignant bone marrow disorders diagnosed most often in elderly white persons. MDS have significant clinical consequences, including cytopenias leading to infection, bleeding, and death; and approximately one-third of cases progress to acute myeloid leukemia (AML). Only one potentially curative therapy exists-allogeneic hematopoietic stem cell transplant (HSCT)-but this therapy is not widely used due to associated morbidity and mortality in elderly patients. Recent research suggests MDS occurs more frequently than previously thought and may be responsible for a substantial proportion of unexplained anemias in elderly persons. Incidence of MDS is expected to increase with increases in life expectancy. Therefore, we offer this comprehensive narrative update of MDS to inform the medical community treating the population at risk for MDS, with a focus on MDS epidemiology and clinical management in the United States. This review includes a brief historical background of MDS, provides an overview of the population burden of disease, discusses the molecular pathology of MDS, describes the clinical features and management of MDS, and discusses future directions in MDS research. Our objective is to inform general medicine practitioners and call attention to the need for translational research in MDS.

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Published In

Ann Med

DOI

EISSN

1365-2060

Publication Date

August 2014

Volume

46

Issue

5

Start / End Page

283 / 289

Location

England

Related Subject Headings

  • United States
  • Translational Research, Biomedical
  • Myelodysplastic Syndromes
  • Leukemia, Myeloid, Acute
  • Incidence
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Disease Progression
  • Cardiovascular System & Hematology
  • Anemia
 

Citation

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Troy, J. D., Atallah, E., Geyer, J. T., & Saber, W. (2014). Myelodysplastic syndromes in the United States: an update for clinicians. Ann Med, 46(5), 283–289. https://doi.org/10.3109/07853890.2014.898863
Troy, Jesse D., Ehab Atallah, Julia T. Geyer, and Wael Saber. “Myelodysplastic syndromes in the United States: an update for clinicians.Ann Med 46, no. 5 (August 2014): 283–89. https://doi.org/10.3109/07853890.2014.898863.
Troy JD, Atallah E, Geyer JT, Saber W. Myelodysplastic syndromes in the United States: an update for clinicians. Ann Med. 2014 Aug;46(5):283–9.
Troy, Jesse D., et al. “Myelodysplastic syndromes in the United States: an update for clinicians.Ann Med, vol. 46, no. 5, Aug. 2014, pp. 283–89. Pubmed, doi:10.3109/07853890.2014.898863.
Troy JD, Atallah E, Geyer JT, Saber W. Myelodysplastic syndromes in the United States: an update for clinicians. Ann Med. 2014 Aug;46(5):283–289.

Published In

Ann Med

DOI

EISSN

1365-2060

Publication Date

August 2014

Volume

46

Issue

5

Start / End Page

283 / 289

Location

England

Related Subject Headings

  • United States
  • Translational Research, Biomedical
  • Myelodysplastic Syndromes
  • Leukemia, Myeloid, Acute
  • Incidence
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Disease Progression
  • Cardiovascular System & Hematology
  • Anemia