Skip to main content
Journal cover image

Childhood passive smoke exposure is associated with adult head and neck cancer.

Publication ,  Journal Article
Troy, JD; Grandis, JR; Youk, AO; Diergaarde, B; Romkes, M; Weissfeld, JL
Published in: Cancer Epidemiol
August 2013

INTRODUCTION: Passive smoke is carcinogenic but its association with head and neck squamous cell carcinoma (HNSCC) is uncertain. METHODS: We conducted a case-control study of childhood passive smoke exposure (CPSE) and HNSCC in 858 cases and 806 frequency-matched controls using an interviewer-administered questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated with logistic regression controlling for adult smoking in the total study population, and in never-smokers only (184 cases and 415 controls). CPSE was also studied in oropharyngeal separately from other HNSCC using polytomous logistic regression. RESULTS: CPSE was associated with HNSCC (OR, 1.28; 95% CI, 1.01-1.63) after controlling for adult smoking and other factors. This association was similar in magnitude, although not statistically significant, among subjects who never smoked as adults (OR, 1.19, 95% CI, 0.80-1.76). CPSE was associated more strongly with oropharyngeal cancer (a HNSCC subtype commonly associated with human papillomavirus (HPV) infection) than with HNSCC at non-oropharyngeal sites (OR, 2.02; 95% CI, 1.01-4.06, N=52 cases vs. OR, 1.04; 95% CI, 0.68-1.60, N=132 cases; P-for-heterogeneity=0.08). CONCLUSIONS: Data from this large US-based case control study suggest a role for CPSE in HNSCC etiology.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer Epidemiol

DOI

EISSN

1877-783X

Publication Date

August 2013

Volume

37

Issue

4

Start / End Page

417 / 423

Location

Netherlands

Related Subject Headings

  • Young Adult
  • United States
  • Tobacco Smoke Pollution
  • Surveys and Questionnaires
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Troy, J. D., Grandis, J. R., Youk, A. O., Diergaarde, B., Romkes, M., & Weissfeld, J. L. (2013). Childhood passive smoke exposure is associated with adult head and neck cancer. Cancer Epidemiol, 37(4), 417–423. https://doi.org/10.1016/j.canep.2013.03.011
Troy, Jesse D., Jennifer R. Grandis, Ada O. Youk, Brenda Diergaarde, Marjorie Romkes, and Joel L. Weissfeld. “Childhood passive smoke exposure is associated with adult head and neck cancer.Cancer Epidemiol 37, no. 4 (August 2013): 417–23. https://doi.org/10.1016/j.canep.2013.03.011.
Troy JD, Grandis JR, Youk AO, Diergaarde B, Romkes M, Weissfeld JL. Childhood passive smoke exposure is associated with adult head and neck cancer. Cancer Epidemiol. 2013 Aug;37(4):417–23.
Troy, Jesse D., et al. “Childhood passive smoke exposure is associated with adult head and neck cancer.Cancer Epidemiol, vol. 37, no. 4, Aug. 2013, pp. 417–23. Pubmed, doi:10.1016/j.canep.2013.03.011.
Troy JD, Grandis JR, Youk AO, Diergaarde B, Romkes M, Weissfeld JL. Childhood passive smoke exposure is associated with adult head and neck cancer. Cancer Epidemiol. 2013 Aug;37(4):417–423.
Journal cover image

Published In

Cancer Epidemiol

DOI

EISSN

1877-783X

Publication Date

August 2013

Volume

37

Issue

4

Start / End Page

417 / 423

Location

Netherlands

Related Subject Headings

  • Young Adult
  • United States
  • Tobacco Smoke Pollution
  • Surveys and Questionnaires
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Logistic Models
  • Humans