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Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Publication ,  Journal Article
Troy, JD; Hartge, P; Weissfeld, JL; Oken, MM; Colditz, GA; Mechanic, LE; Morton, LM
Published in: Am J Epidemiol
June 15, 2010

Prospective studies of lifestyle and non-Hodgkin lymphoma (NHL) are conflicting, and some are inconsistent with case-control studies. The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was used to evaluate risk of NHL and its subtypes in association with anthropometric factors, smoking, and alcohol consumption in a prospective cohort study. Lifestyle was assessed via questionnaire among 142,982 male and female participants aged 55-74 years enrolled in the PLCO Trial during 1993-2001. Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards regression. During 1,201,074 person-years of follow-up through 2006, 1,264 histologically confirmed NHL cases were identified. Higher body mass index (BMI; weight (kg)/height (m)(2)) at ages 20 and 50 years and at baseline was associated with increased NHL risk (P(trend) < 0.01 for all; e.g., for baseline BMI > or =30 vs. 18.5-24.9, hazard ratio = 1.32, 95% confidence interval: 1.13, 1.54). Smoking was not associated with NHL overall but was inversely associated with follicular lymphoma (ever smoking vs. never: hazard ratio = 0.62, 95% confidence interval: 0.45, 0.85). Alcohol consumption was unrelated to NHL (drinks/week: P(trend) = 0.187). These data support previous studies suggesting that BMI is positively associated with NHL, show an inverse association between smoking and follicular lymphoma (perhaps due to residual confounding), and do not support a causal association between alcohol and NHL.

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Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

June 15, 2010

Volume

171

Issue

12

Start / End Page

1270 / 1281

Location

United States

Related Subject Headings

  • United States
  • Smoking
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Lymphoma, Non-Hodgkin
  • Lymphoma, Follicular
 

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Troy, J. D., Hartge, P., Weissfeld, J. L., Oken, M. M., Colditz, G. A., Mechanic, L. E., & Morton, L. M. (2010). Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Epidemiol, 171(12), 1270–1281. https://doi.org/10.1093/aje/kwq085
Troy, Jesse D., Patricia Hartge, Joel L. Weissfeld, Martin M. Oken, Graham A. Colditz, Leah E. Mechanic, and Lindsay M. Morton. “Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.Am J Epidemiol 171, no. 12 (June 15, 2010): 1270–81. https://doi.org/10.1093/aje/kwq085.
Troy JD, Hartge P, Weissfeld JL, Oken MM, Colditz GA, Mechanic LE, et al. Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Epidemiol. 2010 Jun 15;171(12):1270–81.
Troy, Jesse D., et al. “Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.Am J Epidemiol, vol. 171, no. 12, June 2010, pp. 1270–81. Pubmed, doi:10.1093/aje/kwq085.
Troy JD, Hartge P, Weissfeld JL, Oken MM, Colditz GA, Mechanic LE, Morton LM. Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Epidemiol. 2010 Jun 15;171(12):1270–1281.
Journal cover image

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

June 15, 2010

Volume

171

Issue

12

Start / End Page

1270 / 1281

Location

United States

Related Subject Headings

  • United States
  • Smoking
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Lymphoma, Non-Hodgkin
  • Lymphoma, Follicular