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Cardiac troponin release following hybrid coronary revascularization versus off-pump coronary artery bypass surgery.

Publication ,  Journal Article
Harskamp, RE; Abdelsalam, M; Lopes, RD; Boga, G; Hirji, S; Krishnan, M; Kiljanek, L; Mumtaz, M; Tijssen, JG; McCarty, C; de Winter, RJ; Bachinsky, WB
Published in: Interact Cardiovasc Thorac Surg
December 2014

OBJECTIVES: Cardiac ischaemic marker release is associated with adverse clinical outcomes after cardiac surgery. We sought to compare the release of cardiac troponin I (cTnI) after hybrid coronary revascularization (HCR) with off-pump coronary artery bypass surgery (OPCAB). METHODS: Using data from a prospective single-centre registry, we compared cTnI measured at postoperative day 1 following one-stage HCR and OPCAB among patients with normal baseline cTnI. Multivariable linear regression analysis was used to adjust for variables that may have influenced cardiac marker release other than the used revascularization strategy. RESULTS: Sixty-five consecutive patients underwent elective HCR (n = 33) or OPCAB (n = 32). Overall, no differences were seen in comorbidities, CABG risk scores and the lesion-specific SYNTAX score. Procedural complications were lower (15.2 vs 34.4%, P = 0.072), but 30-day and 1-year clinical outcomes (death, myocardial infarction, and repeat revascularization) were similar between the two groups (3.0 vs 3.1% and 9.1 vs 6.2%, respectively). Post-procedural cTnI release measured at 24 h after surgery was significantly lower following HCR compared with OPCAB [ratio of upper reference level URL: median: 3.5, interquartile range (IQR): 0.8-9.1 vs 12.8, IQR: 6.9-21.8, P = 0.001]. After adjusting for potential confounders, HCR was associated, on average, with cTnI less than half (46%) compared with CABG (P <0.0001). CONCLUSIONS: HCR is associated with lower postoperative cTn release, compared with OPCAB. Further research into the clinical implications of this finding is warranted.

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Published In

Interact Cardiovasc Thorac Surg

DOI

EISSN

1569-9285

Publication Date

December 2014

Volume

19

Issue

6

Start / End Page

1008 / 1012

Location

England

Related Subject Headings

  • Troponin I
  • Treatment Outcome
  • Time Factors
  • Risk Factors
  • Retrospective Studies
  • Respiratory System
  • Registries
  • Percutaneous Coronary Intervention
  • Myocardial Infarction
  • Multivariate Analysis
 

Citation

APA
Chicago
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Harskamp, R. E., Abdelsalam, M., Lopes, R. D., Boga, G., Hirji, S., Krishnan, M., … Bachinsky, W. B. (2014). Cardiac troponin release following hybrid coronary revascularization versus off-pump coronary artery bypass surgery. Interact Cardiovasc Thorac Surg, 19(6), 1008–1012. https://doi.org/10.1093/icvts/ivu297
Harskamp, Ralf E., Murad Abdelsalam, Renato D. Lopes, Gouthami Boga, Sameer Hirji, Mrinalini Krishnan, Lukasz Kiljanek, et al. “Cardiac troponin release following hybrid coronary revascularization versus off-pump coronary artery bypass surgery.Interact Cardiovasc Thorac Surg 19, no. 6 (December 2014): 1008–12. https://doi.org/10.1093/icvts/ivu297.
Harskamp RE, Abdelsalam M, Lopes RD, Boga G, Hirji S, Krishnan M, et al. Cardiac troponin release following hybrid coronary revascularization versus off-pump coronary artery bypass surgery. Interact Cardiovasc Thorac Surg. 2014 Dec;19(6):1008–12.
Harskamp, Ralf E., et al. “Cardiac troponin release following hybrid coronary revascularization versus off-pump coronary artery bypass surgery.Interact Cardiovasc Thorac Surg, vol. 19, no. 6, Dec. 2014, pp. 1008–12. Pubmed, doi:10.1093/icvts/ivu297.
Harskamp RE, Abdelsalam M, Lopes RD, Boga G, Hirji S, Krishnan M, Kiljanek L, Mumtaz M, Tijssen JG, McCarty C, de Winter RJ, Bachinsky WB. Cardiac troponin release following hybrid coronary revascularization versus off-pump coronary artery bypass surgery. Interact Cardiovasc Thorac Surg. 2014 Dec;19(6):1008–1012.
Journal cover image

Published In

Interact Cardiovasc Thorac Surg

DOI

EISSN

1569-9285

Publication Date

December 2014

Volume

19

Issue

6

Start / End Page

1008 / 1012

Location

England

Related Subject Headings

  • Troponin I
  • Treatment Outcome
  • Time Factors
  • Risk Factors
  • Retrospective Studies
  • Respiratory System
  • Registries
  • Percutaneous Coronary Intervention
  • Myocardial Infarction
  • Multivariate Analysis