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Advances in the management of pulmonary disease due to Mycobacterium abscessus complex.

Publication ,  Journal Article
Koh, W-J; Stout, JE; Yew, W-W
Published in: Int J Tuberc Lung Dis
October 2014

Mycobacterium abscessus complex is a group of rapidly growing mycobacteria, and an emerging cause of non-tuberculous mycobacterial lung disease in patients with cystic fibrosis and chronic lung diseases, such as bronchiectasis. M. abscessus complex is the most drug-resistant of the mycobacterial pathogens, resulting in limited therapeutic options and a high treatment failure rate. M. abscessus complex is comprised of three closely related subspecies: M. abscessus (sensu stricto), M. massiliense and M. bolletii. M. abscessus encodes a functional erythromycin ribosomal methylase gene, erm(41), which modifies the binding site for macrolide antibiotics, causing inducible macrolide resistance. However, this inducible macrolide resistance is not seen in M. massiliense, as the erm(41) gene of this subspecies is non-functional. Accordingly, treatment success rates with macrolide-based antibiotic treatment are much higher in patients with M. massiliense infections than in those infected with M. abscessus. Precise speciation of M. abscessus complex is important for predicting antibiotic susceptibilities and patient outcome.

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Published In

Int J Tuberc Lung Dis

DOI

EISSN

1815-7920

Publication Date

October 2014

Volume

18

Issue

10

Start / End Page

1141 / 1148

Location

France

Related Subject Headings

  • Prevalence
  • Nontuberculous Mycobacteria
  • Mycobacterium Infections, Nontuberculous
  • Microbiology
  • Macrolides
  • Lung Diseases
  • Humans
  • Drug Resistance, Bacterial
  • Disease Management
  • Anti-Bacterial Agents
 

Citation

APA
Chicago
ICMJE
MLA
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Koh, W.-J., Stout, J. E., & Yew, W.-W. (2014). Advances in the management of pulmonary disease due to Mycobacterium abscessus complex. Int J Tuberc Lung Dis, 18(10), 1141–1148. https://doi.org/10.5588/ijtld.14.0134
Koh, W. -. J., J. E. Stout, and W. -. W. Yew. “Advances in the management of pulmonary disease due to Mycobacterium abscessus complex.Int J Tuberc Lung Dis 18, no. 10 (October 2014): 1141–48. https://doi.org/10.5588/ijtld.14.0134.
Koh W-J, Stout JE, Yew W-W. Advances in the management of pulmonary disease due to Mycobacterium abscessus complex. Int J Tuberc Lung Dis. 2014 Oct;18(10):1141–8.
Koh, W. .. J., et al. “Advances in the management of pulmonary disease due to Mycobacterium abscessus complex.Int J Tuberc Lung Dis, vol. 18, no. 10, Oct. 2014, pp. 1141–48. Pubmed, doi:10.5588/ijtld.14.0134.
Koh W-J, Stout JE, Yew W-W. Advances in the management of pulmonary disease due to Mycobacterium abscessus complex. Int J Tuberc Lung Dis. 2014 Oct;18(10):1141–1148.

Published In

Int J Tuberc Lung Dis

DOI

EISSN

1815-7920

Publication Date

October 2014

Volume

18

Issue

10

Start / End Page

1141 / 1148

Location

France

Related Subject Headings

  • Prevalence
  • Nontuberculous Mycobacteria
  • Mycobacterium Infections, Nontuberculous
  • Microbiology
  • Macrolides
  • Lung Diseases
  • Humans
  • Drug Resistance, Bacterial
  • Disease Management
  • Anti-Bacterial Agents