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Updating the Wnt pathways.

Publication ,  Journal Article
Yu, J; Virshup, DM
Published in: Biosci Rep
October 17, 2014

In the three decades since the discovery of the Wnt1 proto-oncogene in virus-induced mouse mammary tumours, our understanding of the signalling pathways that are regulated by the Wnt proteins has progressively expanded. Wnts are involved in an complex signalling network that governs multiple biological processes and cross-talk with multiple additional signalling cascades, including the Notch, FGF (fibroblast growth factor), SHH (Sonic hedgehog), EGF (epidermal growth factor) and Hippo pathways. The Wnt signalling pathway also illustrates the link between abnormal regulation of the developmental processes and disease manifestation. Here we provide an overview of Wnt-regulated signalling cascades and highlight recent advances. We focus on new findings regarding the dedicated Wnt production and secretion pathway with potential therapeutic targets that might be beneficial for patients with Wnt-related diseases.

Duke Scholars

Published In

Biosci Rep

DOI

EISSN

1573-4935

Publication Date

October 17, 2014

Volume

34

Issue

5

Location

England

Related Subject Headings

  • Wnt1 Protein
  • Wnt Signaling Pathway
  • Receptors, Notch
  • Proto-Oncogene Mas
  • Protein Serine-Threonine Kinases
  • Neoplasms
  • Mice
  • Humans
  • Hippo Signaling Pathway
  • Hedgehog Proteins
 

Citation

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ICMJE
MLA
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Yu, J., & Virshup, D. M. (2014). Updating the Wnt pathways. Biosci Rep, 34(5). https://doi.org/10.1042/BSR20140119
Yu, Jia, and David M. Virshup. “Updating the Wnt pathways.Biosci Rep 34, no. 5 (October 17, 2014). https://doi.org/10.1042/BSR20140119.
Yu J, Virshup DM. Updating the Wnt pathways. Biosci Rep. 2014 Oct 17;34(5).
Yu, Jia, and David M. Virshup. “Updating the Wnt pathways.Biosci Rep, vol. 34, no. 5, Oct. 2014. Pubmed, doi:10.1042/BSR20140119.
Yu J, Virshup DM. Updating the Wnt pathways. Biosci Rep. 2014 Oct 17;34(5).

Published In

Biosci Rep

DOI

EISSN

1573-4935

Publication Date

October 17, 2014

Volume

34

Issue

5

Location

England

Related Subject Headings

  • Wnt1 Protein
  • Wnt Signaling Pathway
  • Receptors, Notch
  • Proto-Oncogene Mas
  • Protein Serine-Threonine Kinases
  • Neoplasms
  • Mice
  • Humans
  • Hippo Signaling Pathway
  • Hedgehog Proteins