[Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster].
Publication
, Journal Article
Latypova, EM; Timoshenko, SI; Kislik, GA; Vitek, M; Shvartsman, AL; Sarantseva, SV
Published in: Biomed Khim
2014
The neuroprotective activity of apolipoprotein E (apoE) peptide mimetic Cog1410, containing amino acid sequence of the receptor-binding domain apoE, has been investigated in transgenic lines of Drosophila melanogaster expressing human APP and beta-secretase. Expression of two transgenes caused neuropathological processes attributed to Alzheimer's disease: neurodegeneration, cognitive abnormality and amyloid deposits formation in brain. It was shown that Cog 1410 reduces neurodegeneration in brain of transgenic flies and improves cognitive functions (odor recognition). These data suggest that Cog1410 is a potential neuroprotector that can be used in AD treatment.
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Published In
Biomed Khim
DOI
ISSN
2310-6972
Publication Date
2014
Volume
60
Issue
4
Start / End Page
515 / 521
Location
Russia (Federation)
Related Subject Headings
- Transgenes
- Olfactory Perception
- Odorants
- Neuroprotective Agents
- Humans
- Gene Expression
- Drosophila melanogaster
- Disease Models, Animal
- Cognition
- Brain
Citation
APA
Chicago
ICMJE
MLA
NLM
Latypova, E. M., Timoshenko, S. I., Kislik, G. A., Vitek, M., Shvartsman, A. L., & Sarantseva, S. V. (2014). [Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster]. Biomed Khim, 60(4), 515–521. https://doi.org/10.18097/pbmc20146004515
Latypova, E. M., S. I. Timoshenko, G. A. Kislik, M. Vitek, A. L. Shvartsman, and S. V. Sarantseva. “[Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster].” Biomed Khim 60, no. 4 (2014): 515–21. https://doi.org/10.18097/pbmc20146004515.
Latypova EM, Timoshenko SI, Kislik GA, Vitek M, Shvartsman AL, Sarantseva SV. [Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster]. Biomed Khim. 2014;60(4):515–21.
Latypova, E. M., et al. “[Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster].” Biomed Khim, vol. 60, no. 4, 2014, pp. 515–21. Pubmed, doi:10.18097/pbmc20146004515.
Latypova EM, Timoshenko SI, Kislik GA, Vitek M, Shvartsman AL, Sarantseva SV. [Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster]. Biomed Khim. 2014;60(4):515–521.
Published In
Biomed Khim
DOI
ISSN
2310-6972
Publication Date
2014
Volume
60
Issue
4
Start / End Page
515 / 521
Location
Russia (Federation)
Related Subject Headings
- Transgenes
- Olfactory Perception
- Odorants
- Neuroprotective Agents
- Humans
- Gene Expression
- Drosophila melanogaster
- Disease Models, Animal
- Cognition
- Brain