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E proteins in lymphocyte development and lymphoid diseases.

Publication ,  Journal Article
Belle, I; Zhuang, Y
Published in: Curr Top Dev Biol
2014

As members of the basic helix-loop-helix (bHLH) family of transcription factors, E proteins function in the immune system by directing and maintaining a vast transcriptional network that regulates cell survival, proliferation, differentiation, and function. Proper activity of this network is essential to the functionality of the immune system. Aberrations in E protein expression or function can cause numerous defects, ranging from impaired lymphocyte development and immunodeficiency to aberrant function, cancer, and autoimmunity. Additionally, disruption of inhibitor of DNA-binding (Id) proteins, natural inhibitors of E proteins, can induce additional defects in development and function. Although E proteins have been investigated for several decades, their study continues to yield novel and exciting insights into the workings of the immune system. The goal of this chapter is to discuss the various classical roles of E proteins in lymphocyte development and highlight new and ongoing research into how these roles, if compromised, can lead to disease.

Duke Scholars

Published In

Curr Top Dev Biol

DOI

EISSN

1557-8933

Publication Date

2014

Volume

110

Start / End Page

153 / 187

Location

United States

Related Subject Headings

  • Receptors, Antigen
  • Neoplasms
  • Lymphocytes
  • Lymphatic Diseases
  • Humans
  • Developmental Biology
  • Cell Survival
  • Cell Differentiation
  • Basic Helix-Loop-Helix Transcription Factors
  • Autoimmune Diseases
 

Citation

APA
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ICMJE
MLA
NLM
Belle, I., & Zhuang, Y. (2014). E proteins in lymphocyte development and lymphoid diseases. Curr Top Dev Biol, 110, 153–187. https://doi.org/10.1016/B978-0-12-405943-6.00004-X
Belle, Ian, and Yuan Zhuang. “E proteins in lymphocyte development and lymphoid diseases.Curr Top Dev Biol 110 (2014): 153–87. https://doi.org/10.1016/B978-0-12-405943-6.00004-X.
Belle I, Zhuang Y. E proteins in lymphocyte development and lymphoid diseases. Curr Top Dev Biol. 2014;110:153–87.
Belle, Ian, and Yuan Zhuang. “E proteins in lymphocyte development and lymphoid diseases.Curr Top Dev Biol, vol. 110, 2014, pp. 153–87. Pubmed, doi:10.1016/B978-0-12-405943-6.00004-X.
Belle I, Zhuang Y. E proteins in lymphocyte development and lymphoid diseases. Curr Top Dev Biol. 2014;110:153–187.

Published In

Curr Top Dev Biol

DOI

EISSN

1557-8933

Publication Date

2014

Volume

110

Start / End Page

153 / 187

Location

United States

Related Subject Headings

  • Receptors, Antigen
  • Neoplasms
  • Lymphocytes
  • Lymphatic Diseases
  • Humans
  • Developmental Biology
  • Cell Survival
  • Cell Differentiation
  • Basic Helix-Loop-Helix Transcription Factors
  • Autoimmune Diseases