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Exposures, mechanisms, and impacts of endocrine-active flame retardants.

Publication ,  Journal Article
Dishaw, LV; Macaulay, LJ; Roberts, SC; Stapleton, HM
Published in: Current opinion in pharmacology
December 2014

This review summarizes the endocrine and neurodevelopmental effects of two current-use additive flame retardants (FRs), tris (1,3-dichloro-isopropyl) phosphate (TDCPP) and Firemaster(®) 550 (FM 550), and the recently phased-out polybrominated diphenyl ethers (PBDEs), all of which were historically or are currently used in polyurethane foam applications. Use of these chemicals in consumer products has led to widespread exposure in indoor environments. PBDEs and their hydroxylated metabolites appear to primarily target the thyroid system, likely due to their structural similarity to endogenous thyroid hormones. In contrast, much less is known about the toxicity of TDCPP and FM 550. However, recent in vitro and in vivo studies suggest that both should be considered endocrine disruptors as studies have linked TDCPP exposure with changes in circulating hormone levels, and FM 550 exposure with changes in adipogenic and osteogenic pathways.

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Published In

Current opinion in pharmacology

DOI

EISSN

1471-4973

ISSN

1471-4892

Publication Date

December 2014

Volume

19

Start / End Page

125 / 133

Related Subject Headings

  • Pharmacology & Pharmacy
  • Organophosphorus Compounds
  • Organophosphates
  • Humans
  • Halogenated Diphenyl Ethers
  • Flame Retardants
  • Environmental Exposure
  • Endocrine Disruptors
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
 

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Dishaw, L. V., Macaulay, L. J., Roberts, S. C., & Stapleton, H. M. (2014). Exposures, mechanisms, and impacts of endocrine-active flame retardants. Current Opinion in Pharmacology, 19, 125–133. https://doi.org/10.1016/j.coph.2014.09.018
Dishaw, Laura V., Laura J. Macaulay, Simon C. Roberts, and Heather M. Stapleton. “Exposures, mechanisms, and impacts of endocrine-active flame retardants.Current Opinion in Pharmacology 19 (December 2014): 125–33. https://doi.org/10.1016/j.coph.2014.09.018.
Dishaw LV, Macaulay LJ, Roberts SC, Stapleton HM. Exposures, mechanisms, and impacts of endocrine-active flame retardants. Current opinion in pharmacology. 2014 Dec;19:125–33.
Dishaw, Laura V., et al. “Exposures, mechanisms, and impacts of endocrine-active flame retardants.Current Opinion in Pharmacology, vol. 19, Dec. 2014, pp. 125–33. Epmc, doi:10.1016/j.coph.2014.09.018.
Dishaw LV, Macaulay LJ, Roberts SC, Stapleton HM. Exposures, mechanisms, and impacts of endocrine-active flame retardants. Current opinion in pharmacology. 2014 Dec;19:125–133.
Journal cover image

Published In

Current opinion in pharmacology

DOI

EISSN

1471-4973

ISSN

1471-4892

Publication Date

December 2014

Volume

19

Start / End Page

125 / 133

Related Subject Headings

  • Pharmacology & Pharmacy
  • Organophosphorus Compounds
  • Organophosphates
  • Humans
  • Halogenated Diphenyl Ethers
  • Flame Retardants
  • Environmental Exposure
  • Endocrine Disruptors
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences